N-Chromosome Royal Jelly, Propolis and Bee Pollen Supplementation Improve the Clinical Conditions of COVID-19 Patients: A Randomized Controlled Trial
Royal jelly, propolis, and bee pollen are used for different purposes all around the world according to their anti-inflammatory, antioxidant, and antimicrobial activities. Given that Coronavirus 2019 (COVID-19) is a viral condition accompanied by a dysregulated inflammatory response in the body, we intend to evaluate the effects of natural supplementations on the disease course. A randomized, open-label, controlled trial was conducted among 50 definitive cases of COVID-19. These patients were randomly assigned into control and intervention groups. Royal Jelly, propolis, and bee pollen were prescribed to patients in the intervention group (n = 24) in addition to conventional treatment; while the control group only received the standard treatment (n = 26). At the end of the study, functional class improved in both groups, but this change was more pronounced in the intervention group (p < 0.05). Moreover, total symptoms duration and the time to return to work were significantly reduced in the intervention group (p < 0.05). Although royal jelly, propolis, and bee pollen are not definitive treatments in COVID-19 patients, they can be used as an adjuvant treatment to limit disease symptoms and virus propagation.
Radermecker C, Detrembleur N, Guiot J, Cavalier E, Henket M, et al. Neutrophil extracellular traps infiltrate the lung airway, interstitial, and vascular compartments in severe COVID-19. J Exp Med 2020;217:e20201012.
Qin C, Zhou L, Hu Z, Zhang S, Yang S, et al. Dysregulation of immune response in patients with coronavirus 2019 (COVID-19) in wuhan, china. Clin Infect Dis 2020;71:762-768.
Coopersmith CM, Antonelli M, Bauer SR, Deutschman CS, Evans LE, et al. The surviving sepsis campaign: research priorities for coronavirus disease 2019 in critical illness. Crit Care Med 2021;49:598-622.
Cascella M, Rajnik M, Aleem A, Dulebohn SC, de Napoli R. Features, evaluation, and treatment of coronavirus (COVID-19). StatPearls [Internet] 2021.
Kaur J, Kaur R, Kaur A. Infectious Diseases and Your Health. Springer. 2018; pp 307-316.
Yuan H, Ma Q, Ye L, Piao G. The traditional medicine and modern medicine from natural products. Molecules 2016;21:559.
Eteraf-Oskouei T, Najafi M. Traditional and modern uses of natural honey in human diseases: A review. Iran J Basic Med Sci 2013;16:731-742.
Samarghandian S, Farkhondeh T, Samini F. Honey and health: A review of recent clinical research. Pharmacognosy Res 2017;9:121-127.
Sforcin JM, Bankova V, Kuropatnicki AK. Medical benefits of honeybee products. Evid Based Complement Alternat Med 2017;2017:2702106.
Ranger A, Haji R, Kaczmarski R, Danga A. Interleukin-6 blockade treatment for COVID-19 associated cytokine release syndrome in a patient with poorly controlled chronic myeloid leukaemia. Br J Haematol 2020;190:e128-e130.
Rahmanzade R, Rahmanzadeh R, Hashemian SM, Tabarsi P. Iran’s approach to COVID-19: evolving treatment protocols and ongoing clinical trials. Front Public Heal 2020;8:523.
Shi Y, Wang Y, Shao C, Huang J, Gan J, et al. COVID-19 infection: the perspectives on immune responses. Cell Death Differ 2020;27:1451-1454.
Merad M, Martin JC. Pathological inflammation in patients with COVID-19: a key role for monocytes and macrophages. Nat Rev Immunol 2020;20:355-362.
Khazaei M, Ansarian A, Ghanbari E. New findings on biological actions and clinical applications of royal jelly: a review. J Diet Suppl 2018;15:757-775.
Viuda-Martos M, Ruiz-Navajas Y, Fernández-López J, Pérez-Álvarez JA. Functional properties of honey, propolis, and royal jelly. J Food Sci 2008;73:R117-R124.
Refaat H, Mady FM, Sarhan HA, Rateb HS, Alaaeldin E. Optimization and evaluation of propolis liposomes as a promising therapeutic approach for COVID-19. Int J Pharm 2021;592:120028.
El Sayed SM, Aboonq MS, El Rashedy AG, Aljehani YT, Abou El-Magd RM, et al. Promising preventive and therapeutic effects of TaibUVID nutritional supplements for COVID-19 pandemic: towards better public prophylaxis and treatment (a retrospective study). Am J Blood Res 2020;10:266-282.
Duarte Silveira MA, De Jong D, Dos Santos Galvão EB, Ribeiro JC, Silva TC, et al. Efficacy of propolis as an adjunct treatment for hospitalized COVID-19 patients: a randomized, controlled clinical trial. MedRxiv 2021:2021.01.08.20248932.
|Issue||Vol 6, No 4, 2021|
|Royal jelly Bee pollen Propolis Hyperinflammation Corona virus disease 2019 (COVID-19)|
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