Medicinal Properties of Cydonia Oblonga Mill Fruit (Pulp and Peel) in Iranian Traditional Medicine and Modern Phytothrapy

  • Fatemeh Aliasl Department of Traditional Pharmacy, School of Traditional Medicine, Tehran University of Medical Sciences, Tehran, Iran
  • Tayebeh Toliyat Department of Pharmaceutics, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  • Ali Mohammadi Department of Drug and Food Control, School of Pharmacy AND Medical Nanotechnology Research Center, Tehran University of Medical Sciences, Tehran, Iran
  • Bagher Minaee Department of Traditional Medicine, School of Traditional Medicine AND Department of Histology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  • Nasrin Samadi Department of Drug and Food Control, Pharmaceutical Sciences Research Center AND Medicinal Plant Research Center, Tehran University of Medical Sciences, Tehran, Iran
  • Jale Aliasl Traditional Medicine Clinical Trial Research Center, Shahed University, Tehran, Iran
  • Omid Sadeghpour The Research Institute for Islamic and Complementary Medicine, Iran University of Medical Sciences, Tehran, Iran
Keywords: Cydonia oblonga, Phytotherapy, Quince, Traditional medicine, Pharmacology, Phytochemistry

Abstract

Cydonia oblonga Mill is commonly  known as quince. It seems to have been used since the ancient  time.  Quince  is a popular  fruit  because  of its health  promoting  properties.  It is an undeniable  fact that there is a positive relationship  between a diet rich in plant foods and a diminish  incidence  of cancer,  cardiovascular  and other diseases.  The aim of this study  was demonstrating  pharmacologic  properties of quince (pulp and peel), view of Iranian traditional medicine (ITM) and modern phytotherapy. For this purpose, Pubmed, Elseveir, Scopus, SID and Google scholar were searched for the key terms “Cydonia oblonga” and “Quince” up to 20st June 2015, and also Iranian traditional medicine manuscripts and herbal medicine books were studied. All experimental and animal studies that included the evidences of fruit (pulp and peel) written in this article were selected for review. Quince has various pharmacological  properties including antioxidant,  anti-allergic,  anti-inflammatory,  anticancer,  antibacterial,  and anticolitis properties and effects on blood pressure and blood rheology, and also has several traditional medicine uses. In Iranian traditional medicine, quince pulp is effective on the most important and vital organs like brain, heart and liver. This fruit is a valuable source of compounds with health-promoting properties and can be used as good sources of antioxidants in our diet and may have use in the prevention and treatment of heart, brain and gastrointestinal diseases

References

Ghasemi Dehkordi N. Iranian Herbal Pharmacopoeia. Ministry of Health, Treatment and Medical Education. Tehran, Iran 2002. [In Persian].

Silva BM, Andrade PB, Valentao P, Ferreres F, Seabra RM, Ferreira MA. Quince (Cydonia oblonga Miller) fruit (pulp, peel, and seed) and Jam:antioxidant activity. J Agric Food Chem 2004; 52:4705-4712.

Parsa A. Flora of Iran. University of Tehran Publications. Tehran, Iran 1948. [In Persian].

Duron M, Decourtye L, Druart PH. Quince. In: Biotechnology in agriculture and forestry. Ed, YPS Bajaj. Springer Science and Business Media, Berlin, Germany, 1989; pp. 42-58.

GironÚs Vilaplana A, Baenas N, Villano D, Moreno DA. Iberian-American fruits rich in bioactive phytochemicals for nutrition and health [Online]. [cited 2014]; Available from: URL: http://www.redcornucopia.org/uploads/formacion/ Documentos/8/139246408313Libro%20Frutos%2 0CYTED%202014%20ISBN_978%2084%2015413%2024%200.pdf

Salehi MH, Mansori MS. Medicinal plants and phytotherapy. Donyae Taghzeih Publications.Tehran, Iran 2010. [In Persian].

Szychowski PJ, Munera-Picazo S, Szumny A, Carbonell-Barrachina ÁA, Hernández F. Quality parameters, bio-compounds, antioxidant activity and sensory attributes of Spanish quinces (Cydonia oblonga Miller). Scientia Horticulturae 2014; 165:163-170.

Huber R, Stintzing FC, Briemle D, Beckmann C, Meyer U, Grundemann C. In vitro antiallergic effects of aqueous fermented preparations from Citrus and Cydonia fruits. Planta Med 2012; 78:334-340.

Silva BM, Andrade PB, Martins RC, Valentao P, Ferreres F, Seabra RM, et al. Quince (Cydonia oblonga miller) fruit characterization using principal component analysis. J Agric Food Chem 2005; 53: 111-122.

Silva BM, Andrade PB, Ferreres F, Domingues AL, Seabra RM, Ferreira MA. Phenolic profile of quince fruit (Cydonia oblonga Miller) (pulp and peel). J Agric Food Chem 2002; 50: 4615-4618.

Silva BM, Casal S, Andrade PB, Seabra RM, Oliveira MB, Ferreira MA. Development and evaluation of a GC/FID method for the analysis of free amino acids in quince fruit and jam. Anal Sci 2003; 19: 1285-1290.

Silva BM, Andrade PB, Martin RC, Seabra RM, Ferreira MA. Principal component analysis as tool of characterization of quince (Cydonia oblonga Miller) jam. Food Chemistry 2006; 94: 504-512.

Silva BM, Casal S, Andrade PB, Seabra RM, Oliveira MB, Ferreira MA. Free amino acid composition of quince (Cydonia oblonga Miller)fruit (pulp and peel) and jam. J Agric Food Chem 2004; 52: 1201-1206.

Wojdylo A, Teleszko M, Oszmianski J.Antioxidant property and storage stability of quince juice phenolic compounds. Food Chem 2014; 152: 261-270.

Silva BM, Andrade PB, Mendes GC, Seabra RM, Ferreira MA. Study of the organic acids composition of quince (Cydonia oblonga Miller) fruit and jam. J Agric Food Chem 2002; 50: 2313-2317.

Sousa C, Silva BM, Andrade PB, Valentão P, Silva A, Ferreres F, et al. Homo-monoterpenic compounds as chemical markers for Cydonia oblonga Miller. Food Chemistry 2007; 100: 331-338.

Lim TK. Edible medicinal and non-medicinal plants: Volume 1, fruits. Springer Science and Business Media. Berlin, Germany 2012.

Aghili Alavi Khorasani SMH. Makhzan-al-Advia.Tehran University of Medical Sciences. Tehran, Iran 2009. [In Persian].

Avicenna. The canon of medicine. Alamy le-al- Matbooat Institute. Beirut, Lebanon 2005. [In Arabic].

Elsadig Karar M, Pletzer D, Jaiswal R, Weingart H, Kuhnert N. Identification, characterization, isolation and activity against Escherichia coli ofquince (Cydonia oblonga) fruit polyphenols. Food Research International 2014; 65: 121-129.

Fattouch S, Caboni P, Coroneo V, Tuberoso CI, Angioni A, Dessi S, et al. Antimicrobial activity of Tunisian quince (Cydonia oblonga Miller) pulp and peel polyphenolic extracts. J Agric Food Chem 2007; 55: 963-969.

Fattouch S, Caboni P, Coroneo V, Tuberoso C, Angioni A, Dessi S, et al. Comparative analysis of polyphenolic profiles and antioxidant and antimicrobial activities of tunisian pome fruit pulp and peel aqueous acetone extracts. J Agric Food Chem 2008; 56: 1084-1090.

Babarikina A, Nikolajeva V, Babarykin D. Anti- Helicobacter activity of certain food plant extracts and juices and their composition in vitro. Food and Nutrition Sciences, 2011; 2: 868-877.

Zaidi SF, Yamada K, Kadowaki M, Usmanghani K, Sugiyama T. Bactericidal activity of medicinal plants, employed for the treatment of gastrointestinal ailments, against Helicobacter pylori. J Ethnopharmacol 2009; 121: 286-291.

Hamauzu Y, Yasui H, Inno T, Kume C, Omanyuda M. Phenolic profile, antioxidant property, and anti-influenza viral activity of Chinese quince (Pseudocydonia sinensis Schneid.), quince (Cydonia oblonga Mill.), and apple (Malus domestica Mill.) fruits. J Agric Food Chem 2005;53: 928-934.

Magalhaes AS, Silva BM, Pereira JA, Andrade PB, Valentao P, Carvalho M. Protective effect of quince (Cydonia oblonga Miller) fruit against oxidative hemolysis of human erythrocytes. Food Chem Toxicol 2009; 47: 1372-1377.

Pacifico S, Gallicchio M, Fiorentino A, Fischer A, Meyer U, Stintzing FC. Antioxidant properties and cytotoxic effects on human cancer cell lines of aqueous fermented and lipophilic quince (Cydonia oblonga Mill.) preparations. Food Chem Toxicol 2012; 50: 4130-4135.

Yilmaz E, l Karadeniz F. Effect of storage on the bioactive compounds and antioxidant activity of quince nectar. International Journal of Food Science & Technology 2014; 49: 718-725.

Carvalho M, Silva BM, Silva R, Valentao P, Andrade PB, Bastos ML. First report on Cydonia oblonga Miller anticancer potential: differential antiproliferative effect against human kidney and colon cancer cells. J Agric Food Chem 2010; 58:3366-3370.

Zhou W, Abdusalam E, Abliz P, Reyim N, Tian S, Aji Q, et al. Effect of Cydonia oblonga Mill. fruit and leaf extracts on blood pressure and blood rheology in renal hypertensive rats. J Ethnopharmacol 2014; 152: 464-469.

Aslam M, Sial AA. Effect of Hydroalcoholic extract of cydonia oblonga miller (Quince) on sexual behaviour of wistar rats. Adv PharmacolSci 2014; 2014: 6.

Shinomiya F, Hamauzu Y, Kawahara T. Anti- allergic effect of a hot-water extract of quince (Cydonia oblonga). Biosci Biotechnol Biochem 2009; 73: 1773-1778.

Kawahara T, Iizuka T. Erratum to: Inhibitory effect of hot-water extract of quince (Cydonia oblonga) on immunoglobulin E-dependent late- phase immune reactions of mast cells. Cytotechnology 2011; 63: 541-542.

Grundemann C, Papagiannopoulos M, Lamy E, Mersch-Sundermann V, Huber R.Immunomodulatory properties of a lemon-quince preparation (Gencydo(R)) as an indicator of anti- allergic potency. Phytomedicine 2011; 18: 760-768.

Essafi-Benkhadir K, Refai A, Riahi I, Fattouch S,Karoui H, Essafi M. Quince (Cydonia oblonga Miller) peel polyphenols modulate LPS-induced inflammation in human THP-1-derived macrophages through NF-kappaB, p38MAPK and Akt inhibition. Biochem Biophys Res Commun 2012; 418: 180-185.

Minaiyan M, Ghannadi A, Etemad M, Mahzouni P. A study of the effects of Cydonia oblonga Miller (Quince) on TNBS-induced ulcerative colitis in rats. Res Pharm Sci 2012; 7: 103-110.

Mirmohammadlu M, Hosseini SH, Kamalinejad M, Esmaeili GM, Noubarani M, Eskandari MR. Hypolipidemic, Hepatoprotective and Renoprotective Effects of Cydonia Oblonga Mill. Fruit in Streptozotocin-Induced Diabetic Rats. Iran J Pharm Res 2015; 14: 1207-1214.

Tansaz M, Akhtari E, Bioos T, Mokaberinejad R.The efficacy of cydonia oblonga extract on infant's reflux: A pilot study. Iran J Pediatr 2013; 23: 16.

Jafari-Dehkordi E. Effect of Cydonia Oblonga in Nausea and Vomiting in Pregnancy in Traditional Iranian medicine [thesis]. Iran University of Medical Sciences, Iran; 2013. [In Persian].

Aliasl F, Toliyat T, Aliasl J, Minaee MB. Nausea and vomiting remedies in Iranian Traditional Medicine (ITM). Iran J Public Health 2015; 44:1164-1165.

Published
2016-10-04
How to Cite
1.
Aliasl F, Toliyat T, Mohammadi A, Minaee B, Samadi N, Aliasl J, Sadeghpour O. Medicinal Properties of Cydonia Oblonga Mill Fruit (Pulp and Peel) in Iranian Traditional Medicine and Modern Phytothrapy. Trad Integr Med. 1(3):122-128.
Section
Review Article(s)