A Traditional Iranian Medicine (Majoon-e Loboob) for Idiopathic Male Infertility: A Case Series
Abstract
Infertility is defined as the inability to conceive after 12 or more months of regular intercourse without contraception. Sperm abnormalities are introduced as 20-47% of infertility etiology. Idiopathic male subfertility is common (40-50%). In the Iranian traditional medicine, many natural drugs are used for enhancing fertility. This case series was an effort to understand the role of an Iranian traditional formulation in conception. For this purpose, 13 men with infertility and idiopathic oligoasthenoteratospermia were treated by 10 g Majoon-e Loboob twice daily. 11 (84.6%) of their wives became pregnant after 4.8 ± 2.0 months. In men with severe oligoasthenospermia (< 0.1 × 106/ml), no pregnancy occurred and their spermogram remained unchanged. However, libido and erectile function showed improvement in all patients. No adverse events have been reported by patients. Majoon-e Loboob could be considered as a complementary medicine for treatment of idiopathic infertility. Some of the natural components in this formulation have proven pharmacological activity in conception including Zingiber officinale and Myristica fragrans.
Practice Committee of American Society for Reproductive Medicine. Definitions of infertility and recurrent pregnancy loss. Fertil Steril 2008; 90(5 Suppl): S60.
Mosher WD, Pratt WF. Fecundity and Infertility in the United States, 1965-88. Hyattsville, MD: National Center for Health Statistics (U.S.); 1990.
World Health Organization. Towards more objectivity in diagnosis and management of male infertility. Int J Androl 1987; 7(Suppl 1): 19-33.
de Kretser DM. Male infertility. Lancet 1997; 349(9054): 787-90.
Vandekerckhove P, Lilford R, Vail A, Hughes E. Androgens versus placebo or no treatment for idiopathic oligo/asthenospermia. Cochrane Database Syst Rev 2000; (2): CD000150.
Kamischke A, Behre HM, Bergmann M, Simoni M, Schafer T, Nieschlag E. Recombinant human follicle stimulating hormone for treatment of male idiopathic infertility: a randomized, double-blind, placebo-controlled, clinical trial. Hum Reprod 1998; 13(3): 596-603.
Foresta C, Bettella A, Merico M, Garolla A, Ferlin A, Rossato M. Use of recombinant human follicle- stimulating hormone in the treatment of male factor infertility. Fertil Steril 2002; 77(2): 238-44.
Speroff L, Fritz MA. Clinical gynecologic endocrinology and infertility. Philadelphia, PA: Lippincott Williams & Wilkins; 2005.
Myers ER, McCrory DC, Mills AA, Price TM, Swamy GK, antibhedhyangkul J, et al. Effectiveness of assisted reproductive technology (ART). Evid Rep Technol Assess (Full Rep) 2008; (167): 1-195.
Kwan I, Bhattacharya S, McNeil A, van Rumste MM. Monitoring of stimulated cycles in assisted reproduction (IVF and ICSI). Cochrane database Syst Rev 2008; (2): CD005289.
Tanbo T, Kjekshus E, Dale PO, Storeng R, Lunde O, Magnus O, et al. [Intracytoplasmic sperm injection]. Tidsskr Nor Laegeforen 1998; 118(6): 864-9.
van Steirteghem A, Nagy P, Joris H, Janssenswillen C, Staessen C, Verheyen G, et al. Results of intracytoplasmic sperm injection with ejaculated, fresh and frozen-thawed epididymal and testicular spermatozoa. Hum Reprod 1998; 13(Suppl 1): 134-42.
Garcea N, Campo S, Garcea R. [The ICSI (Intracytoplasmic Sperm Injection)]. Minerva Ginecol 1998; 50(6): 239-53.
Eshre Capri Workshop Group. Intrauterine insemination. Hum Reprod Update 2009; 15(3): 265-77.
van Rumste MM, Custers IM, van der Veen M, van Wely M, Evers JL, Mol BW. The influence of the number of follicles on pregnancy rates in intrauterine insemination with ovarian stimulation: a meta-analysis. Hum Reprod Update 2008; 14(6): 563-70.
Azamkhan M. Exir Azam. Tehran, Iran: Research Institute for Islamic and Complementary Medicine; 50 Trad Integr Med 2015; Vol. 1, No. 1 Bioos, et al. 2009. [In Persian].
Aghili Khorasani MH. Moalejat Aghili. Tehran, Iran: Research Institute for Islamic and Complementary Medicine; 2009. [In Persian].
Kermani A. Al-Asbab va Al-Amanat. Qom, Iran: Jalaledin Publication; 2009. [In Persian].
Masoumi SZ, Poorolajal J, Keramat A, Moosavi SA. Prevalence of depression among infertile couples in Iran: a meta-analysis study. Iran J Public Health 2013; 42(5): 458-66.
Hodjat M, Talebian A, Akhondi MA, Zeraati H, Shabani A, Sadeghi MR. Sperm Ubiquitination Correlation with Human Semen Quality. Iran J Public Health 2008; 37(2): 32-40.
Wang ZQ, Huang YQ, Liang B. Clinical observation on electroacupuncture and Chinese drug for treatment of oligospermia and asthenospermia of the male infertility patient. Zhongguo Zhen Jiu 2008;28(11): 805-7. [In Chinese].
Maosong L, Jican D. Evaluation of treatment of oligospermia or asthenozoospermia infertility with combination of Chinese Traditional and Western medicine with new criteria. Journal of Modern Urology 2004; 4: 223-5.
Jorsaraei SG, Yousefnia YR, Zainalzadeh M, Moghadamnia AA, Beiky AA, Damavandi MR. The effects of methanolic extracts of ginger (Zingiber officinale) on human sperm parameters; an in vitro study. Pak J Biol Sci 2008; 11(13): 1723-7.
Tajuddin, Ahmad S, Latif A, Qasmi IA, Amin KM. An experimental study of sexual function improving effect of Myristica fragrans Houtt. (nutmeg). BMC Complement Altern Med 2005; 5: 16.
Sultana A, Rahman K, Nagaraj RB. Conception in unilateral right tubal blockage with herbomineral formulations: a case report. J Altern Complement Med 2011; 17(6): 557-61.
Heller CG, Clermont Y. Spermatogenesis in man: an estimate of its duration. Science 1963; 140(3563): 184-6.
Rojhan MS. Basic human histology. Tehran, Iran: Chehr publication; 1993. [In Persian].
Rowley MJ, Teshima F, Heller CG. Duration of transit of spermatozoa through the human male ductular system. Fertil Steril 1970; 21(5): 390-6.
Files | ||
Issue | Vol 1, No 1, 2016 | |
Section | Case Studies | |
Keywords | ||
Iranian traditional medicine Male infertility Majoon-e Loboob Sperm parameter Natural remedy |
Rights and permissions | |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |