Tehran University of Medical Sciences Traditional and Integrative Medicine 2476-5104 1 1 2015 11 11 47 51 EN Soodabeh Bioos Department of Iranian Traditional Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran Esmail Nazem Department of Iranian Traditional Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran Mansoor Keshavarz Department of Iranian Traditional Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran Marzieh Beigom Siahpoosh Research Institute for Islamic and Complementary Medicine, Iran University of Medical Sciences, Tehran, Iran Farnaz Sohrabvand Department of Obstetrics and Gynecology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran Hamid Sohanaki Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran Fatemeh Nejatbakhsh Department of Iranian Traditional Medicine, School of Traditional Medicine, Tehran University of Medical Sciences, Tehran, Iran 2015 10 05 2015 10 05 Infertility is defined as the inability to conceive after 12 or more months of regular intercourse without  contraception.  Sperm abnormalities  are  introduced  as  20-47%  of  infertility  etiology. Idiopathic  male  subfertility  is  common  (40-50%).  In  the  Iranian  traditional  medicine,  many natural drugs are used for enhancing fertility. This case series was an effort to understand the role of an Iranian traditional formulation in conception. For this purpose, 13 men with infertility and idiopathic oligoasthenoteratospermia were treated by 10 g Majoon-e Loboob twice daily. 11 (84.6%) of their wives became pregnant after 4.8 ± 2.0 months. In men with severe oligoasthenospermia (< 0.1 × 106/ml), no pregnancy occurred and their spermogram remained unchanged. However, libido and erectile function showed improvement in all patients. No adverse events have been reported by patients. Majoon-e Loboob could be considered as a complementary medicine  for  treatment  of  idiopathic  infertility.  Some  of  the  natural  components  in  this formulation have proven pharmacological activity in conception including Zingiber officinale and Myristica fragrans. https://jtim.tums.ac.ir/index.php/jtim/article/view/8 https://jtim.tums.ac.ir/index.php/jtim/article/download/8/33