Anti –Inflammatory Effect of Methanolic and Aqueous Extracts of Urtica pilulifera L. Seed in Rats
-
Alireza Abbassian
,
Ahmad Massoud
,
Mohsen Naseri
,
Mohammad Kamalinejad
,
Parvaneh Mohseni-Moghaddam
,
Fatemeh Emadi
,
Arman Zargaran
Abstract
Wide range of acute and chronic inflammatory ailments, side effects of their available therapies and incomplete treatment of such patients push the researches to find new and more effective drugs. To reach this aim, in the current study, we evaluate Urtica pilulifera L. (family Urticaceae) as an introduced traditional herb for treatment of inflammation in Persian Medicine (PM). In an animal study, Anti – inflammatory effects of U. pilulifera were surveyed in rats on the basis hind paw edema model which it’s inflammation induced with formalin. Sodium Salicylate (300mg/kg, ip, S.S) injection was used as a positive control group and compared with methanolic extract of U. pilulifera (20 mg/kg; i.p.) (MUP), three different doses of aqueous extract of U. pilulifera (20, 40 and 80 mg/kg; i.p.) (AUP) and a group of distilled water (6 mL/kg ; i.p.). As acute anti-inflammatory effect, AUP in doses 40 and 80mg/kg (i.p.) decreased edema significantly (p<0.05). In chronic anti- inflammatory response, results indicate that all AUP groups had anti- inflammatory effects (p <0.05) with no significant difference by the S.S group. In conclusion, AUP had anti-inflammatory effects on both acute and chronic edema while MUP was just effective in chronic anti-inflammatory studies.
Katzung BG. Basic and clinical pharmacology. McGraw-Hill, 8th ed. New York 2001; pp 1088-1089.
Chowdhury MA, Abdellatif KRA, Don Y, Das D, Suresh MR et al. Synthesis of celecoxib analogues possessing a N-Difluoromethyl-1, 2-dihydropyrid-2-one s-Lipoxygenase pharmacophore: Biological evaluation as dual inhibitors of cyclooxygenases and 5-Lipoxygenase with anti-inflammatory activity. J Med Chem 2009;52:1525-1529.
Tranvsky K, Fischer M, Vögtle-Junkert U, Schreyger F. Efficacy and safety of 5% ibuprofen cream treatment in knee osteoarthritis. Results of a randomized, double blind, placebo controlled study. J Rheumatol 2004;31:565-572.
Van Haselen RA, Fisher PA. A randomized controlled trial comparing topical piroxicam gel with a homeopathic gel in osteoarthritis of the knee. Rheumatology 2000;39:714-719.
Zarshenas MM, Zargaran A, Blaschke M. Convenient, traditional and alternative therapies for cardiovascular disorders. Curr Pharm Des 2017;23:1112-1118.
Negahban A, Maleki M, Abbassian A. Policies and laws related to the integration of traditional and complementary medicine into the Iranian health system based on the WHO definition: A document analysis. J Educ Health Promot. 2019;8:221.
Zargaran A. Ancient persian medical views on the heart and blood in the Sassanid era (224-637 AD). Int J Cardiol 2014;172:307-312.
Abbassian A. Anti-inflammatory effects of Urtica pilulifera L. seeds extracts in the rat. [PhD Thesis]. Tehran: Tehran University of Medical Sciences; 2003.
Zargari A. Medicinal Plants. Vol. 3. Tehran University Press. 1st ed. Tehran 1989; pp 1-5.
Hossaini MT. Tohfe al Momenin, Vol 1. Noore vahy. Qom 2011; p 150.
Avicenna. Al- Qanun fi al-Tibb (Canon of Medicine). Volume 9. Alamy Le-Al-Matbooat institute. Lebanon 2005; pp 365-366.
Rhazes. Al Havi (Liber Continent). Iranian Academy of Medical Sciences Publication. Tehran 2005; pp 61-63.
Tabib Esfarayeni MA. Taghvim-ol-Advieh. Almae. Tehran 2014; p 28.
Dr. Duke's Phytochemical and Ethnobotanical Databases. 2006. Available at: URL: http://www.ars-grin.gov/cgi-bin/ duke/farmacy2.pl. Accessed in 24 Dec. 2016.
Kavalali G, Tuncel H. Anti- inflammatory activities of Urtica pilulifera. Pharm Biol 1997;35:138-140.
Kalagatur NK, Kamasani JR, Mudili V. Assessment of detoxification efficacy of irradiation on zearalenone mycotoxin in various fruit juices by response surface methodology and elucidation of its in-vitro toxicity. Front Microbiol 2018;9:2937.
Kumar VL, Basu N. Anti-inflammatory activity of the latex of Calotropis procera. J Ethnopharmacol 1994;44:123-125.
Fereidoni M, Ahmadiani A, Semnanian S, Javan M. An accurate and simple method for measurement of paw edema. J Pharmacol Toxicol Meth 2000;43:11-14.
Khalili M, Rezazarandi M, Vahid S. Anti-inflammatory effect of alcoholic Urtica dioica extract in male NMRI rats. J Basic Clinic Pathophysiol 2012;1:24-28.
Balke D, Diosady LL. Rapid aqueous extraction of mucilage from whole white mustard seed. Food Res Int 2000;33:347-356.
Hajhashemi V, Klooshani V. Antinociceptive and anti inflammatory effects of Urtica dioica leaf extract in animal models. Avicenna J Phytomed 2013;3:193-200.
Mzid M, Ben Khedir S, Bardaa S, Sahnoun Z, Rebai T. Chemical composition, phytochemical constituents, antioxidant and anti-inflammatory activities of Urtica urens L. leaves. Arch Physiol Biochem 2016;14:1-12.
Peter SJ, Sabina EP. Global current trends in natural products for diabetes management: a review. Int J Pharm Pharm Sci 2016;8:20-28.
Vazquez B, Avila G, Seura D, Escalante B. Anti-inflammatory activity of extracts from Aloe vera gel. J Ethnopharmacol 1996;55:69-75.
Suh N, Honda T, Finaly HJ, Barchowsky A, Williams C, et al. Novel triterpenoids suppress inducible nitric oxide synthase (iNOS) and inducible cyclooxygenase (COX-2) in mouse macrophages. Cancer Res 1998;58:717-723.
Huss U, Ringbom T, Perera P, Bohlin L, Vasange M. Screening of ubiquitous plant constituents for COX-2 inhibition with a scintillation proximity based assay. J Nat Prod 2002;65:1517-1521.
Kang H, Ku SK, Kim J, Chung J, Kim SC, Zhou W, Na M, Bae JS. Anti-vascular inflammatory effects of pentacyclic triterpenoids from Astilbe rivularis in vitro and in vivo. Chem Biol Interact 2017; 261:127-38
Lee SR, Lee S, Moon E, Park HJ, Park HB, et al. Bioactivity-guided isolation of anti-inflammatory triterpenoids from the sclerotia of Poria cocos using LPS-stimulated Raw264.7 cells. Bioorg Chem 2017;70:94-99.
Abudoleh S, Disi A, Qunaibi E, Aburjai T. Anti-Arthritic Activity of the Methanolic Leaf Extract of Urtica pilulifera L. on Albino Rats. Am J Pharmacol Toxicol 2011;6: 27-32.
Liu T, Zhang L, Joo D, Sun SC. NF-κB signaling in inflammation. Sig Transduct Target Ther 2017;2:e17023.
Al-Khayri JM, Sahana GR, Nagella P, Joseph BV, Alessa FM, et al. Flavonoids as potential anti-inflammatory molecules: a review. Molecules 2022;27:2901.
González R, Ballester I, López-Posadas R, Suárez MD, Zarzuelo A, et al. Effects of flavonoids and other polyphenols on inflammation. Crit Rev Food Sci Nutr 2011;51:331-362.
| Files | ||
| Issue | Vol 8, No 2, 2023 | |
| Section | Research Article(s) | |
| DOI | https://doi.org/10.18502/tim.v8i2.13080 | |
| Keywords | ||
| Urtica Pilulifera Inflammation Rat Persian medicine | ||
| Rights and permissions | |
|
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
