Alpha-amylase Inhibitory Activity of Sitopaladi Churna: An Ayurvedic Formula

  • Kolavanahalli Pillegowda-Smitha Department of Pharmaceutics, Sri K.V. College of Pharmacy, Chickballapur, Karnataka, India
  • Kuruba Srinivas-Kulashekar Department of Pharmacology, Sri K.V. College of Pharmacy, Chickballapur, Karnataka, India
  • Thotlaganahalli Krishnappa-Pavithra Department of Pharmaceutics, Sri K.V. College of Pharmacy, Chickballapur, Karnataka, India
  • Bagepalli Srinivas-Ashok-Kumar Department of Pharmacognosy, Sri K.V. College of Pharmacy, Chickballapur, Karnataka, India
  • Gopi Setty-Saran Department of Pharmaceutics, Sri K.V. College of Pharmacy, Chickballapur, Karnataka, India
Sitopaladi Churna, Ayurvedic Formula, Diabetes, Alpha Amylase, Dinitrosalicylic Acid


Sitopaladi Churna is an ayurvedic formula, traditionally used as anti-inflammatory, carminative, sedative, expectorant, anti-infective, and various respiratory disorders. The aim of the present study is to screening for alpha amylase (α-amylase) inhibition activity of aqueous extract of Sitopaladi Churna. In vitro α-amylase inhibition activity of Sitopaladi Churna was screened by the 3,5-dinitrosalicylic acid method. Sitopaladi Churna showed potent (α-amylase) inhibitory activity with an IC50  - 46.38 µ g/ml. Thus, Sitopaladi Churna may consider as a remedy for diabetes and other  insulin  resistance-related  diseases;  however,  animal  and  human  studies  are  needed  to confirm this activity.


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How to Cite
Pillegowda-Smitha K, Srinivas-Kulashekar K, Krishnappa-Pavithra T, Srinivas-Ashok-Kumar B, Setty-Saran G. Alpha-amylase Inhibitory Activity of Sitopaladi Churna: An Ayurvedic Formula. Trad Integr Med. 1(1):40-43.
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