Tehran University of Medical Sciences Traditional and Integrative Medicine 2476-5104 1 1 2015 11 11 40 43 EN Kolavanahalli Pillegowda-Smitha Department of Pharmaceutics, Sri K.V. College of Pharmacy, Chickballapur, Karnataka, India Kuruba Srinivas-Kulashekar Department of Pharmacology, Sri K.V. College of Pharmacy, Chickballapur, Karnataka, India Thotlaganahalli Krishnappa-Pavithra Department of Pharmaceutics, Sri K.V. College of Pharmacy, Chickballapur, Karnataka, India Bagepalli Srinivas-Ashok-Kumar Department of Pharmacognosy, Sri K.V. College of Pharmacy, Chickballapur, Karnataka, India Gopi Setty-Saran Department of Pharmaceutics, Sri K.V. College of Pharmacy, Chickballapur, Karnataka, India 2015 10 05 2015 10 05 Sitopaladi Churna is an ayurvedic formula, traditionally used as anti-inflammatory, carminative, sedative, expectorant, anti-infective, and various respiratory disorders. The aim of the present study is to screening for alpha amylase (α-amylase) inhibition activity of aqueous extract of Sitopaladi Churna. In vitro α-amylase inhibition activity of Sitopaladi Churna was screened by the 3,5-dinitrosalicylic acid method. Sitopaladi Churna showed potent (α-amylase) inhibitory activity with an IC50  - 46.38 µ g/ml. Thus, Sitopaladi Churna may consider as a remedy for diabetes and other  insulin  resistance-related  diseases;  however,  animal  and  human  studies  are  needed  to confirm this activity. https://jtim.tums.ac.ir/index.php/jtim/article/view/6 https://jtim.tums.ac.ir/index.php/jtim/article/download/6/31