The Effect of Jollab Beverage on Fatigue and Happiness in Patients with Multiple Sclerosis: A Triple-Blind Randomized Clinical Trial
-
Zahra Gholami
,
Shahin Heidari
,
Mahboobeh Raieszadeh
,
Alimohammad Madahian
,
Fatemeh Ayoobi
,
Alireza Vakilian
,
Zahra Jamali
,
Tabandeh Sadeghi
Abstract
Multiple sclerosis (MS) causes different physical and mental symptoms. Fatigue and decrease of happiness are the common problems in MS patients. This study aimed to determine the effect of Jollab beverage on fatigue and happiness in MS patients. In this triple-blind clinical trial, 70 MS patients visiting the MS Association in an urban area of Iran were randomly assigned to the two groups by minimization method. The intervention group consumed Jollab beverage, including a combination of saffron (Crocus sativus L.), rose water (Rosa x damascena Herrm.) and brown sugar (Saccharum officinarum L.), three times a day orally, 15 mL each time for four weeks. The control group consumed placebo similar to the intervention group. Fatigue and happiness of the patients were evaluated before and after the intervention using Oxford happiness questionnaire and fatigue severity scale. Data were analyzed using SPSS software. Based on the results, there was no statistically significant difference between two groups in the mean score of fatigue and happiness before the intervention. But, after the intervention, the mean score of fatigue was lower in the intervention (34.66 ± 7.72) vs. control group (39.12 ± 9.22) CI: 0.26, 8.64, p=0.03). However, the mean score of happiness after the intervention was not statistically significant between the intervention (39.21 ± 17.46) and control ( 45.12 ± 14.30) groups (CI: -1.93, 13.75, p=0.13). According to the results, the use of Jollab beverage can reduce the fatigue of MS patients. Therefore, use of this beverage can be recommended to the patients by neurologists and MS associations.
Hosseininezhad M, Saadat S, Bakhshipour H, Nasiri P. Prevalence and incidence of Multiple Sclerosis (MS) in guilan province. J Shahid Sadoughi Uni Med Sci 2021;29:3438-3447.
Payamani F, Nazari A, Noktehdan H, Ghadiriyan F, Karami K. Complementary therapy in patients with Multiple Sclerosis. Iran J Nurs 2012;25:12-20.
Moghadasi AN. History of Multiple Sclerosis in Iran. Arch Iran Med 2020;23:211-215.
Shakhs Bolandghadr A, Noferesti A, Rostami R. The effect of yoga exercises on depression, overt and covert anxiety in women with multiple sclerosis. Rooyesh-e-Ravanshenasi journal (RRJ). 2020;9:79-90.
Ford H. Clinical presentation and diagnosis of multiple sclerosis. Clin Med 2020;20:380.
Manjaly Z-M, Harrison NA, Critchley HD, Do CT, Stefanics G, et al. Pathophysiological and cognitive mechanisms of fatigue in multiple sclerosis. J Neurol Neurosurg Psychiatry 2019;90:642-651.
Khajoei S, Hassaninevisi M, Kianmehr N, Seif F, Khoshmirsafa M, et al. Serum levels of adiponectin and vitamin D correlate with activity of Rheumatoid Arthritis. Mol Biol Rep 2019;46:2505-2512.
Asano M, Finlayson ML. Meta-analysis of three different types of fatigue management interventions for people with multiple sclerosis: exercise, education, and medication. Mult Scler Int 2014;2014:798285.
Papalardo A, Reggio E. Management of fatigue in multiple sclerosis. Europa Bedico Physic 2003;32:147-151.
Zifko UA. Therapy of day time fatigue in patients with multiple sclerosis. Wiener medizinische Wochenschrift (1946). 2003;153:65-72.
Dayapoglu N, Tan M. Use of complementary and alternative medicine among people with multiple sclerosis in Eastern Turkey. Neurol Asia 2016;21:63-71.
Majdinasab N, Namjoyan F, Taghizadeh M, Saki H. The effect of evening primrose oil on fatigue and quality of life in patients with multiple sclerosis. Neuropsychiatr Dis Treat 2018;14:1505-1512.
Pasalar M, Choopani R, Mosaddegh M, Kamalinejad M, Mohagheghzadeh A, et al. Efficacy and safety of Jollab to treat functional dyspepsia: a randomized placebo–controlled clinical trial. Explore 2015;11:199-207.
Momen Tonekaboni M. Tohfe-al-momenin.: Iran University of Medical Science. Tehran 2007.
Ahmadi S, Azhari S, Jafarzadeh H, Rakhshandeh H, Mazlom R. The effect of oral capsules of saffron on anxiety and fatigue during the first stage of labor. SSU J 2015;23:1915-1926.
Ghorbani M, Tabatabaeichehr M, Bagheri M, Salari E, Nazari S. Effect of saffron on happiness of postmenopausal women: a clinical randomized trial. Iran J Obstet Gynecol Infertil 2019;22:11-17.
Hashemi Siyavoshani M, Fallahi Arezodar F, Pishgooei SA, Jadid_Milani M. The effect of rose water on the anxiety level of aged admitted to cardiac intensive care units. Iran J Nurs Res 2020;15:59-68.
Moein M, Zarshenas MM, Delnavaz S. Chemical composition analysis of rose water samples from Iran. Pharm Biol 2014;52:1358-1361.
Labban L, Thallaj N. The medicinal and pharmacological properties of Damascene Rose (Rosa damascena): A review. 2020;8:33-37.
Azlan A, Khoo HE, Sajak AAB, Aizan Abdul Kadir NA, Yusof BNM, et al. Antioxidant activity, nutritional and physicochemical characteristics, and toxicity of minimally refined brown sugar and other sugars. Food Sci Nutr 2020;8:5048-5062.
Filipčev B, Lević L, Bodroža-Solarov M, Mišljenović N, Koprivica G. Quality characteristics and antioxidant properties of breads supplemented with sugar beet molasses-based ingredients. Int J Food Prop 2010;13:1035-1053.
Safari M, Gholamzadeh A, Asadi A, Mahjour M. The therapeutic and anti-inflammatory effects of ginseng in multiple sclerosis patients. Razi J Med Sci 2020;27:59-69.
Kim E, Cameron M, Lovera J, Schaben L, Bourdette D, et al. American ginseng does not improve fatigue in multiple sclerosis: a single center randomized double-blind placebo-controlled crossover pilot study. Multiple Sclerosis J 2011;17:1523-1526.
Babaki FY, Khodadoost M, Rezaeizadeh H, Moghadasi AN, Fahimi S, et al. Efficacy and safety of “Jollab Monzej” as a traditional persian compound medicine for the treatment of multiple sclerosis-related fatigue: A randomized placebo-controlled trial. Caspian J Intern Med 2023;14:257-266.
Rigi F, Adineh HJN, Journal M. The effect of reflexology massage on the fatigue severity in women with multiple sclerosis. Nurs Midwifery J 2017;14:926-933.
Pandis N. Randomization. part 2: minimization. Am J Orthod Dentofacial Orthop 2011;140:902-904.
Avicenna. Qanoon dar Teb. Translated to Persian by Abdorahman Sharafkandi, sorosh press, Tehran 1988.
Kakoei S, Karbasi N, Raeiszadeh M, Tajadini H, Nekouei AH. The efficacy of henna (Lawsonia inermis L.) mouthwash versus chlorhexidine gluconate 0.2% mouthwash as adjuvant therapy of oral lichen planus: A randomized double-blind clinical trial. J Ethnopharmacol 2022;290:115037.
Mehrabani M, Amirkhosravi A, Farhadi S, Vasei S, Raeiszadeh M, et al. The influence of harvest time on total phenolic and flavonoid contents, antioxidant, antibacterial and cytotoxicity of Rheum khorasanicum root extract. Ann Pharm Fr 2023;81:475-483.
A'zimiyan M, Fallah-Pour M, Karimlou M. Fatigue severity scale (fss): evaluation of reliability of the Persian version among persons with multiple sclerosis. Arch Rehabil 2010;10.
Hadinezhad H, Zaree F. Reliability, validity, and normalization of the Oxford Happiness Questionnaire. Psychol Res 2009;12:62-77.
Ashtiani AR, Amirhossein LS, Jadidi A, Ghasami K, Hezave AK, et al. The effect of novel simple saffron syrup on fatigue reduction in patients with multiple sclerosis. J Basic Clin Physiol Pharmacol 2020;31.
Moratalla-López N, Bagur MJ, Lorenzo C, Martínez-Navarro M, Salinas MR, et al. Bioactivity and bioavailability of the major metabolites of Crocus sativus L. flower. Molecules 2019;24:2827.
Shafiee M, Arekhi S, Omranzadeh A, Sahebkar A. Saffron in the treatment of depression, anxiety and other mental disorders: Current evidence and potential mechanisms of action. J Affect Disord 2018;227:330-337.
Boskabady MH, Farkhondeh T. Antiinflammatory, antioxidant, and immunomodulatory effects of Crocus sativus L. and its main constituents. Phytother Res 2016;30:1072-1094.
Soltani M-K, Shams J, Ghaffari F, Alijaniha F, Naseri M. Effects of saffron (Crocus Sativus Linn) supplementation on happiness and quality of life in healthy adults: a randomized double blind clinical trial. J Pharm Negat Results 2023:2849-2855.
Bagheri M, Afshar M, Sadat Z. the effect of spiritual counseling on happiness among patients with multiple sclerosis. KAUMS J 2021:876-883.
Salmerón-Manzano E, Garrido-Cardenas JA, Manzano-Agugliaro F. Worldwide research trends on medicinal plants. Int J Environ Res Public Health. 2020;17:3376.
Behrens M, Gube M, Chaabene H, Prieske O, Zenon A, et al. Fatigue and human performance: an updated framework. Sports Med 2023;53:7-31.
Singh S, Kshtriya S, Valk R. Health, hope, and harmony: a systematic review of the determinants of happiness across cultures and countries. Int J Environ Res Public Health 2023;20:3306.
Tanzer JR, Weyandt L. Imaging happiness: Meta analysis and review. J Happiness Stud 2020;21:2693-2734.
| Issue | Vol 10, No 1, 2025 -In Press- | |
| Section | Research Article(s) | |
| Keywords | ||
| Multiple Sclerosis Fatigue Happiness Medicinal plants Jollab Persian Medicine | ||
| Rights and permissions | |
|
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
