Tehran University of Medical Sciences Traditional and Integrative Medicine 2476-5104 10 1 2025 03 10 30 37 Zahra Gholami Student Research Committee, School of Nursing and Midwifery, Rafsanjan University of Medical Sciences, Rafsanjan, Iran Shahin Heidari Department of Fundamental Nursing, School of Nursing and Midwifery, Rafsanjan University of Medical Sciences, Rafsanjan, Iran AND Geriatric Care Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran Mahboobeh Raieszadeh Herbal and Traditional Medicines Research Center, Kerman University of Medical Sciences, Kerman, Iran Alimohammad Madahian Department of Internal Medicine, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran AND Physiology-Pharmacology Research Center, Research Institute on Basic Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran Fatemeh Ayoobi Occupational Safety and Health Research Center, NICICO, World Safety Organization and Rafsanjan University of Medical Sciences, Rafsanjan, Iran Alireza Vakilian Department of Internal Medicine, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran AND Non-Communicable Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran Zahra Jamali Non-Communicable Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran Tabandeh Sadeghi Non-Communicable Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran AND Department of Pediatric Nursing, School of Nursing and Midwifery, Rafsanjan University of Medical Sciences, Rafsanjan, Iran 2024 06 02 2024 12 16 Multiple sclerosis (MS) causes different physical and mental symptoms. Fatigue and decrease of happiness are the common problems in MS patients. This study aimed to determine the effect of Jollab beverage on fatigue and happiness in MS patients. In this triple-blind clinical trial, 70 MS patients visiting the MS Association in an urban area of Iran were randomly assigned to the two groups by minimization method. The intervention group consumed Jollab beverage, including a combination of saffron (Crocus sativus L.), rose water (Rosa x damascena Herrm.) and brown sugar (Saccharum officinarum L.), three times a day orally, 15 mL each time for four weeks. The control group consumed placebo similar to the intervention group. Fatigue and happiness of the patients were evaluated before and after the intervention using Oxford happiness questionnaire and fatigue severity scale. Data were analyzed using SPSS software. Based on the results, there was no statistically significant difference between two groups in the mean score of fatigue and happiness before the intervention. But, after the intervention, the mean score of fatigue was lower in the intervention (34.66 ± 7.72) vs. control group (39.12 ± 9.22) CI: 0.26, 8.64, p=0.03). However, the mean score of happiness after the intervention was not statistically significant between the intervention (39.21 ± 17.46) and control ( 45.12 ± 14.30) groups (CI: -1.93, 13.75, p=0.13). According to the results, the use of Jollab beverage can reduce the fatigue of MS patients. Therefore, use of this beverage can be recommended to the patients by neurologists and MS associations. https://jtim.tums.ac.ir/index.php/jtim/article/view/1620 https://jtim.tums.ac.ir/index.php/jtim/article/download/1620/434