Traditional and Integrative Medicine 2017. 2(4):188-195.

A Review of the Anti-oxidation, Anti-inflammatory and Anti-tumor Properties of Curcumin
Hossein Mahdavi, Zohreh Hadadi, Mandana Ahmadi

Abstract


Sinafaravar  pharmaceutical Company  has produced Curcuma-sina that helps people have healthier lives. Curcuma-Sina shows strong anti-oxidation, anti-inflammatory and anti-tumor properties. This product is including Curcuma longa and Piper nigrum. Anti-inflammatory products are being used to remedy chronic inflammatory disorders and cancers. Thus, there is an urgent need to develop safe and effective medicines for the long-term use. Researchers have studied small molecules derived from natural sources with the aim of developing new treatments for clinical features. Curcuma longa and Piper nigrum, are well known to have beneficial clinical effects. Curcuma longa  has various therapeutic effects on different diseases. However, it has limited tissue distribution, low serum levels and apparent rapid metabolism in human. To increase Curcuma longa  bioavailability, Piper nigrum, known as a natural adjuvant increases the bioavailability of Curcuma longa.

Keywords


Curcuma longa; Piper nigrum; Antioxidation; Anti-inflammatory; Anti-tumor

Full Text:

PDF

References


Henrotin Y, Clutterbuck AL, Allaway D. Biological actions of curcumin on articular chondrocytes. O A R S J 2010;18:141-149.

Shen L, Ji H-F. The pharmacology of curcumin: is it the degradation products. Trends Mol Med 2012;18:138-144.

Goel A, Kunnumakkara AB, Aggarwal BB. Curcumin as "Curecumin": from kitchen to clinic. Biochem Pharmacol 2008;75:787-809.

Aggarwal BB, Sung B. Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets. Trends Pharmacol Sci 2009;30:85-94.

Sharma R, Gescher A, Steward W. Curcumin: the story so far. Eur J Cancer 2005;41:1955-1968.

Anand P, Kunnumakkara AB, Newman RA, Aggarwal BB. Bioavailability of curcumin: problems and promises. Mol Pharm 2007;4:807-818.

Hatcher H, Planalp R, Cho J, Torti FM, Torti SV. Curcumin: From ancient medicine to current clinical trials. Cell Mol Life Sci 2008;65:1631-1652.

Kumaravel M, Sankar P, Latha P, Benson CS, Rukkumani R. Anti proliferative effects of an analog of curcumin in Hep-2 cells: a comparative study with curcumin. N P C J 2013;8:183-186.

Masuelli L, Benvenuto M, Fantini M. Curcumin induces apoptosis in breast cancer cell lines and delays the growth of mammary tumors in neu transgenic mice. J B R H A 2012;27:105-119.

Link A, Balaguer F, Shen Y. Curcumin modulates DNA methylation in colorectal cancer cells. PLoS One 2013;8:57709.

Peng F, Tao Q, Wu X. Cytotoxic, cytoprotective and antioxidant effects of isolated phenolic compounds from fresh ginger. Fitoterapia 2012;83:568-585.

Avasarala S, Zhang F, Liu G, Wang R, London SD, London L. Curcumin Modulates the Inflammatory Response and Inhibits Subsequent Fibrosis in a Mouse Model of Viral-induced Acute Respiratory Distress Syndrome. PLoS One 2013;8:57285.

Jovanovic S, Boone CW, Steenken S, Trinoga M, Kaskey RB. How curcumin works preferentially with water soluble antioxidants. J Am Chem Soc 2001;123:3064-3068.

Halliwell B, Whiteman M. Measuring reactive species and oxidative damage in vivo and in cell culture: how should you do it and what do theresults mean. Br J Pharmacol 2004;142:231-255.

Burlakova EB. Russ J Gen Chem 2007;77:1983-1993.

Kancheva VD, Kasaikina OT. Curr Med Chem 2013;20:4784-4805.

Aggarwal BB, Sung B. Trends Pharmacol Sci 2009;30:85-94.

Goel A, Kunnumakkara AB, Aggarwal BB. Biochem Pharmacol 2008;75,787–809.

Joe B, Vijaykumar M, Lokesh BR. Crit Rev ‎Int J Food Sci Nutr 2004;44:97-111.

Marchiani A, Rozzo C, Fadda A, Delogu G, Ruzza P. Curr Med Chem 2014;21:204-222.

Vajragupta O, Boonchoong P, Berliner LJ. Manganese complexes of curcumin analogues: Evaluation of hydroxyl radical scavenging ability, superoxide dismutase activity and stability towards hydrolysis. Free Radic Res 2004;38:303-314.

Barik A, Mishra B, Kunwar A. Comparative study of copper(II) curcumin complexes as superoxide dismutase mimics and free radical scavengers. Eur J Med Chem 2007;42:431-439.

Sreejayan RM. Nitric oxide scavenging by curcuminoids. J Pharm Pharmacol 1997;49:105-107.

Joe B, Lokesh BR. Role of capsaicin, curcumin and dietary n-3 fatty acids in lowering the generation of reactive oxygen species in rat peritoneal macrophages. Biochem Biophys Acta 1994;1224:255-263.

Lin J, Shih CA. Inhibitory effect of curcumin on xanthine dehydrogenase/oxidase induced by phorbol-12-myristate-13-acetate in NIH3T3 cells. Carcinogenesis 1994;15:1717-21.

Thangapazham R, Sharma A, Maheshwari RK. Multiple molecular targets in cancer chemoprevention by curcumin. A A P S J 2006;8:443-449.

Huang MT, Lysz T, Ferraro T. Inhibitory effects of curcumin on in vitro lipoxygenase and cyclooxygenase activities in mouse epidermis. Cancer Res 1991;51:813-819.

Cho JW, Lee KS, Kim CW. Curcumin attenuates the expression of IL-1beta, IL-6, and TNF-alpha as well as cyclin E in TNF-alpha-treated HaCaT cells; NFkappaB and MAPKs as potential upstream targets. Int J Mol Med 2007;19:469-474.

Liu JY, Lin SJ, Lin JK. Inhibitory effects ofcurcumin on protein kinase C activity induced by 12-O-tetradecanoyl-phorbol-13-acetate in NIH 3T3 cells. Carcinogenesis 1993;14:857-861.

Mann J, DuBois RN. Cyclooxygenase-2 and gastrointestinal cancer. Cancer J 2004;10:145-152.

Amit S, Ben-Neriah Y. NF-kappaB activation in cancer: A challenge for ubiquitination- and proteasomebased therapeutic approach. Semin Cancer Biol 2003;13:15-28.

Bennett A. The production of prostanoids in human cancers, and their implications for tumor progression. J Lipid Res 1986;25:539-542.

Qiao L, Kozoni V, Tsioulias GJ. Selected eicosanoids increase the proliferation rate of human colon carcinoma cell lines and mouse colonocytes in-vivo. Biochem Biophys Acta 1995;1258:215-223.

Aggarwal BB, Kumar A, Bharti AC. Anticancer potential of curcumin: preclinical and clinical studies. Anticancer Res 2003;23:363-398.

Ushida J, Sugie S, Kawabata K. Jpn J Cancer Res 2000;91:893-898.

Anand P, Sundaram C, Jhurani S, Kunnumakkara AB, Aggarwal BB. Curcumin and cancer: An “old-age” disease with an “age-old” solution. Cancer Lett 2008;267:133-164.

Aggarwal BB, Gehlot P. Inflammation and cancer: How friendly is the relationship for cancer patients Curr Opin Pharmacol 2009;9:351-369.

Aggarwal BB, Shishodia S, Sandur SK, Pandey M K, Sethi G. Inflammation and cancer: How hot is the link. Biochem Pharmacol 2006;72:1605-1621.

Gupta SC, Prasad S, Kim JH, Patchva S, Webb LJ, Priyadarsini IK, Aggarwal BB. Multitargeting by curcumin as revealed by molecular interaction studies. Nat Prod Rep 2011;28:1937-1955.

Shehzad A, Wahid F, Lee YS. Curcumin in cancer chemoprevention: Molecular targets, pharmacokinetics, bioavailability, and clinical trials. Arch Pharm Weinh 2010;343:489-499.

Anand P, Kunnumakkara AB, Newman RA, Aggarwal BB. Bioavailability of curcumin: Problems and promises. Mol Pharm 2007;4:807-818.

Aggarwal BB, Sundaram CN, Malani H. Ichika- wa, Curcumin: The Indian Solid Gold. Adv Exp Med Biol 2007;595:1-75.

Sharma RA, Euden SA, Platton SL, Cooke DN, Shafayat A, Hewitt HR, Marczylo TH, Morgan B, Hemingway D, Plummer SM. Phase I clinical trial of oral curcumin: Biomarkers of systemic activity and compliance. Clin Cancer Res 2004;10:6847-6854.

Gao Y, Li Z, Sun M, Guo C, Yu A, Xi Y. Preparation and characterization of intravenously injectable curcumin nanosuspension. Drug Deliv 2011;18:131-142.

Gao Y, Li Z, Sun M, Li H, Guo C, Cui J. Preparation, characterization, pharmacokinetics, and tissue distribution of curcumin nano suspension with TPGS as stabilizer. Drug Dev Ind Pharm 2010;36:1225-1234.

Zhongfa L, Chiu M, Wang J, Chen W, Yen W, Fan-Havard P. Enhancement of curcumin oral absorption and pharmacokinetics of curcuminoids and curcumin metabolites in mice. Cancer chemoth oharm 2012;69:679-689.

John MK, Xie H, Bell EC, Liang D. Development and pharmacokinetic evaluation of a curcumin co-solvent formulation. Anticancer Res 2013;33:4285-4291.

Saengkrit N, Saesoo S, Srinuanchai W, Phunpee S, Ruktanonchai UR. Influence of curcumin-loaded cationic liposome on anticancer activity for cervical cancer therapy. Colloids Surf B Biointerfaces 2014;114:349-356.

Liu CW, Xiong F, Jia HZ, Wang XL, Cheng H, Sun YH. Graphene-based anticancer nanosystem and its biosafety evaluation using a zebrafish model. Biomacromolecules 2013;14:358-36.

Shoba G, Joy D, Joseph T, Majeed M, Rajendran R, Srinivas PS. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med 1998;64:353-356.

Suresh D, Srinivasan K. Tissue distribution & elimination of capsaicin, piperine & curcumin following oral intake in rats. Ind J Med Res 2010;131:682-691.

Moorthi C, Krishnan K, Manavalan R, Kathiresan K. Preparation and characterization of curcumin-piperine dual drug loaded nanoparticles. Asian Pac J Trop Biomed 2012;2:841-848.

Moorthi C, Kathiresan K. Curcumin–Piperine/Curcumin–Quercetin/Curcumin–Silibinin dual drug-loaded nanoparticulate combination therapy: A novel approach to target and treat multidrug-resistant cancers. Med Hypotheses 2013;7:15-20.

Doucette CD, Hilchie AL, Liwski R, Hoskin DW. Hoskin piperine, a dietary phytochemical inhibits angiogenesis. J Nutr Biochem 2013;24:231-239.

Selvendiran K, Banu SM, Sakthisekaran D: Oral supplementation of piperine leads to altered phase II enzymes and reduced DNA damage and DNA-protein cross links in benzo(a)pyrene induced experimental lung carcinogenesis. Mol Cell Biochem 2005;268:141-147.

Scholz S, Williamson G. Interactions affecting the bioavailability of dietary polyphenols in vivo. Int J Vitam Nutr Res 2007;77:224-235.

Acharya SG, Momin AH and Gajjar AV. Review of Piperine as A Bio-Enhancer. Am J Pharm Tech Res 2012;2:32-44.

Taqvi SI, Shah AJ, Gilani AH. Blood pressure lowering and vasomodulator effects of piperine. J Cardiovasc Pharmacol 2008;52:452-458.

Manoharan S, Balakrishnan S, Menon V, Alias L, Reena A. Chemopreventive efficacy of curcumin and piperine during 7,12-dimethylbenz[a] anthracene-induced hamster buccal pouch carcinogenesis. Singapore Med J 2009;50:139-146.

Parganiha R, Verma S, Chandrakar S, Pal S, Sawarkar HA, Kashyap P. In vitro anti- asthmatic activity of fruit extract of Piper nigrum (Piperaceae). Int J Herb Med 2011;1:15-18.

Li S, Wang C, Wang M, Li W, Matsumoto K. Antidepressant like effects of piperine in chronic mild stress treated mice and its possible mechanisms. Life Sci 2007;80:1373-1381.

Matsuda H, Ninomiya K, Morikawa T, Yasuda D, Yamaguchi I. Protective effects of amide constituents from the fruit of Piper chaba on D-galactosamine/TNF-alpha-induced cell death in mouse hepatocytes. Bioorg Med Chem Lett 2008;18:2038-2042.

Johnson JJ, Nihal M, Siddiqui IA, Scarlett CO, Bailey HH. Enhancing the bioavailability of resveratrol by combining it with piperine. Mol Nutr Food Res 2011;55:1169-1176.

Wattanathorn J, Chonpathompikunlert P, Muchimapura S, Priprem A, Tankamnerdthai O. Piperine, the potential functional food for mood and cognitive disorders. Food Chem Toxicol 2008;46:3106-3110.

Ahmad N, Fazal H, Abbasi BH, Farooq S, Ali M. Biological role of Piper nigrum L. (Black pepper): A review. A P J T B. 2012:1945-1953.

Selvendiran K, Sakthisekaran D. Chemopreventive effect of piperine on modulating lipid peroxidation and membrane bound enzymes in benzo(a) pyrene induced lung carcinogenesis. Biomed Pharmacother 2004;58:264-267.

Ahmad N, Fazal H, Abbasi BH, Rashid M, Mahmood T, Fatima N. Efficient regeneration and antioxidant potential in regenerated tissues of Piper nigrum L. Plant Cell, Tissue and Organ Culture Plarma Res 2010;102:129-134.

Sunila ES, Kuttan G. Immunomodulatory and antitumor activity of Piper longum Linn and piperine. J Ethnopharmacol 2004;90:339-346.

Pathak N, Khandelwal S. Modulation of cadmium induced alterations in murine thymocytes by piperine: oxidative stress, apoptosis, phenotyping and blastogenesis. Biochem Pharmacol 2006;72:486-497.

Singh R, Singh N, Saini BS, Rao HS. In vitro antioxidant activity of pet ether extract of black pepper. Ind J Pharmacol 2008;40:147-151.

Bang JS, Oh DH, Choi HM, Sur BJ, Lim SJ, Kim JY. Anti-inflammatory and anti-arthritic effects of piperine in human interleukin- 1beta-stimulated fibroblast-like synoviocytes and in rat arthritis models. Arthritis Res Ther 2009;11:49.

Kumar S, Singhal V, Roshan R, Sharma A, Rembhotkar GW, Ghosh B. Piperine inhibits TNF-alpha induced adhesion of neutrophils to endothelial monolayer through suppression of NF-kappaB and IkappaB kinase activation. Eur J Pharmacol 2007;575:177-186.




Traditional and Integrative Medicine(Quarterly)
P-ISSN: 2476-5104,  E-ISSN: 2476-5112 

Tehran University of Medical Sciences, Tehran, Iran. 
Creative Commons Attribution-NonCommercial 3.0

This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.