Tehran University of Medical Sciences Traditional and Integrative Medicine 2476-5104 2 4 2017 12 26 188 195 EN Hossein Mahdavi Research & Development Department, Sinafaravar Pharmaceutical Company, Najaf Abad, Isfahan, Iran Zohreh Hadadi Research & Development Department, Sinafaravar Pharmaceutical Company, Najaf Abad, Isfahan, Iran Mandana Ahmadi Research & Development Department, Sinafaravar Pharmaceutical Company, Najaf Abad, Isfahan, Iran 2017 12 26 2017 12 26 Sinafaravar  pharmaceutical Company  has produced Curcuma-sina that helps people have healthier lives. Curcuma-Sina shows strong anti-oxidation, anti-inflammatory and anti-tumor properties. This product is including Curcuma longa and Piper nigrum. Anti-inflammatory products are being used to remedy chronic inflammatory disorders and cancers. Thus, there is an urgent need to develop safe and effective medicines for the long-term use. Researchers have studied small molecules derived from natural sources with the aim of developing new treatments for clinical features. Curcuma longa and Piper nigrum, are well known to have beneficial clinical effects. Curcuma longa  has various therapeutic effects on different diseases. However, it has limited tissue distribution, low serum levels and apparent rapid metabolism in human. To increase Curcuma longa  bioavailability, Piper nigrum, known as a natural adjuvant increases the bioavailability of Curcuma longa. https://jtim.tums.ac.ir/index.php/jtim/article/view/123 https://jtim.tums.ac.ir/index.php/jtim/article/download/123/113