Research Article

The Effect of Lavender Inhalation on the Pain Perception of Orthodontic Separator Placement: An Open-Label Randomized Controlled Trial

Abstract

Lavandula angustifolia Mill. (lavender) is known for its antibacterial, muscle relaxant, antispasmodic, sedative, and anesthetic effects, and is also proposed to be used as an analgesic agent. Despite several studies on the analgesic activity of lavender, this is the first experiment in patients with orthodontic pain. This "2-arm parallel" study aims to evaluate the effect of lavender oil inhalation on reducing pain after elastomeric separator placement as a part of orthodontic treatment. Patients who needed elastic separator placement in mesial and distal of first permanent molars of all quadrants prior to their first-ever fixed orthodontic treatment, with the age range of 20 to 24, were randomly assigned to one of the two study groups: lavender oil and sesame oil. Participants had to breathe in their medication for 2 minutes just before separator insertion, as well as 4, 8, 12, 24, 36, and 48 h afterward. A visual analog scale (VAS) was used to measure the level of pain during three oral situations, including rest, fitting posterior teeth, and chewing at the following periods: just before separator placement (T0), immediately after insertion (T1), 3 h post-insertion (T2), 12 h post-(T3), 24 insertion h post-insertion (T4), and 48 h after separator placement (T5). The current study indicated the effectiveness of lavender oil inhalation in reducing pain perception while chewing 48 h after elastic separator placement. The pain level in lavender inhalation was lower from 12 h to 48 h after separator insertion, although not considerable, indicating the probability of its effectiveness on delayed responses to orthodontic pain.

Yamaguchi M, Fukasawa S. Is inflammation a friend or foe for orthodontic treatment? inflammation in orthodontically induced inflammatory root resorption and accelerating tooth movement. Int J Mol Sci 2021;22:2388.

Vannala V, Katta A, Reddy MS, Shetty SR, Shetty RM, et al. Periodontal accelerated osteogenic orthodontics technique for rapid orthodontic tooth movement: a systematic review. J Pharm Bioallied Sci 2019;11:S97-S106.

Modarresi J, Aghili H, Karandish M, Jalali B, Zahir ST. Effect of direct electric current on parietal bone osteogenesis. J Craniofac Surg 2012;23:1607-1609.

Raphael-Mizrahi B, Gabet Y. The Cannabinoids effect on bone formation and bone healing. Curr Osteoporos Rep 2020;18:433-438.

Lombardo L, Arreghini A, Ramina F, Huanca Ghislanzoni LT, Siciliani G. Predictability of orthodontic movement with orthodontic aligners: a retrospective study. Prog Orthod 2017;18:35.

Dallel I, Ben Salem I, Merghni A, Bellalah W, Neffati F, et al. Influence of orthodontic appliance type on salivary parameters during treatment. Angle Orthod 2020;90:532-538.

Arijit Y, Kondo H, Miyazawa K, Tabuchi M, Koyama S, et al. Orthodontic tooth separation activates the hypothalamic area in the human brain. Int J Oral Sci 2018;10:8.

Bergius M, Broberg AG, Hakeberg M, Berggren U. Prediction of prolonged pain experiences during orthodontic treatment. Am J Orthod Dentofacial Orthop 2008;133:339.e1-8.

Cioffi I, Michelotti A, Perrotta S, Chiodini P, Ohrbach R. Effect of somatosensory amplification and trait anxiety on experimentally induced orthodontic pain. Eur J Oral Sci 2016;124:127-134.

Vardimon AD, Matsaev E, Lieberman M, Brosh T. Tightness of dental contact points in spaced and non-spaced permanent dentitions. Eur J Orthod 2001;23:305-314.

Ngan P, Wilson S, Shanfeld J, Amini H. The effect of ibuprofen on the level of discomfort in patients undergoing orthodontic treatment. Am J Orthod Dentofacial Orthop 1994;106:88-95.

Saklecha B, Tekale PD, Agarwal CO, Mhaske A, Patil H. A new device to place elastic separators. J Clin Diagn Res 2015;9:Zh01-2.

Tripathi T, Singh N, Rai P, Khanna N. Separation and pain perception of Elastomeric, kesling and kansal separators. Dental Press J Orthod 2019;24:42-48.

Bradley RL, Ellis PE, Thomas P, Bellis H, Ireland AJ, et al. A randomized clinical trial comparing the efficacy of ibuprofen and paracetamol in the control of orthodontic pain. Am J Orthod Dentofacial Orthop 2007;132:511-517.

Bird SE, Williams K, Kula K. Preoperative acetaminophen vs ibuprofen for control of pain after orthodontic separator placement. Am J Orthod Dentofacial Orthop 2007;132:504-510.

Bergius M, Kiliaridis S, Berggren U. Pain in orthodontics. A review and discussion of the literature. J Orofac Orthop 2000;61:125-137.

Tortamano A, Lenzi DC, Haddad AC, Bottino MC, Dominguez GC, et al. Low-level laser therapy for pain caused by placement of the first orthodontic archwire: a randomized clinical trial. Am J Orthod Dentofacial Orthop 2009;136:662-667.

Patel S, McGorray SP, Yezierski R, Fillingim R, Logan H, et al. Effects of analgesics on orthodontic pain. Am J Orthod Dentofacial Orthop 2011;139:e53-58.

Roth PM, Thrash WJ. Effect of transcutaneous electrical nerve stimulation for controlling pain associated with orthodontic tooth movement. Am J Orthod Dentofacial Orthop 1986;90:132-138.

Bernhardt MK, Southard KA, Batterson KD, Logan HL, Baker KA, et al. The effect of preemptive and/or postoperative ibuprofen therapy for orthodontic pain. Am J Orthod Dentofacial Orthop 2001;120:20-27.

Zarif Najafi H, Oshagh M, Salehi P, Babanouri N, Torkan S. Comparison of the effects of preemptive acetaminophen, ibuprofen, and meloxicam on pain after separator placement: a randomized clinical trial. Prog Orthod 2015;16:34.

Al-Melh MA, Andersson L. The effect of a lidocaine/prilocaine topical anesthetic on pain and discomfort associated with orthodontic elastomeric separator placement. Prog Orthod 2017;18:1-3.

Huang MY, Liao MH, Wang YK, Huang YS, Wen HC. Effect of lavender essential oil on LPS-stimulated inflammation. Am J Chin Med 2012;40:845-559.

Forouzanfar F, Forouzanfar A, Sathyapalan T, Orafai HM, Sahebkar A. Curcumin for the management of periodontal diseases: a review. Curr Pharm Des 2020;26:4277-4284.

Khodabandeh Z, Haghighat S, Tanideh N, Zare S, Farrokhi F, et al. Comparing the effects of elaegnus angustifolia, hypericum perforatum and psidium guajava extracts on metabolic activity of dental pulp-derived mesenchymal stem cells. Cell Tissue Bank 2022;23:143-155.

Cruz Martínez C, Diaz Gómez M, Oh MS. Use of traditional herbal medicine as an alternative in dental treatment in Mexican dentistry: a review. Pharm Biol 2017;55:1992-1998.

Bikmoradi A, Khaleghverdi M, Seddighi I, Moradkhani S, Soltanian A, et al. Effect of inhalation aromatherapy with lavender essence on pain associated with intravenous catheter insertion in preschool children: A quasi-experimental study. Complement Ther Clin Pract 2017;28:85-91.

Kritsidima M, Newton T, Asimakopoulou K. The effects of lavender scent on dental patient anxiety levels: a cluster randomised-controlled trial. Community Dent Oral Epidemiol 2010;38:83-87.

Silva GL, Luft C, Lunardelli A, Amaral RH, Melo DA, et al. Antioxidant, analgesic and anti-inflammatory effects of lavender essential oil. Anais da Academia Brasileira de Ciências 2015;87:1397-1408.

Arslan I, Aydinoglu S, Karan NB. Can lavender oil inhalation help to overcome dental anxiety and pain in children? A randomized clinical trial. Eur J Pediatr 2020;179:985-992.

Vaziri F, Shiravani M, Najib FS, Pourahmad S, Salehi A, et al. Effect of lavender oil aroma in the early hours of postpartum period on maternal pains, fatigue, and mood: a randomized clinical trial. Int J Prev Med 2017;8:29.

Bijur PE, Silver W, Gallagher EJ. Reliability of the visual analog scale for measurement of acute pain. Acad Emerg Med 2001;8:1153-1157.

Eslamian L, Torshabi M, Motamedian SR, Hemmati YB, Mortazavi SA. The effect of naproxen patches on relieving orthodontic pain by evaluation of VAS and IL-1β inflammatory factor: a split-mouth study. Dental Press J Orthod 2019;24:27e1-e7.

Barocelli E, Calcina F, Chiavarini M, Impicciatore M, Bruni R, et al. Antinociceptive and gastroprotective effects of inhaled and orally administered Lavandula hybrida Reverchon "Grosso" essential oil. Life Sci 2004;76:213-223.

Ou MC, Hsu TF, Lai AC, Lin YT, Lin CC. Pain relief assessment by aromatic essential oil massage on outpatients with primary dysmenorrhea: a randomized, double-blind clinical trial. J Obstet Gynaecol Res 2012;38:817-822.

Raisi Dehkordi Z, Hosseini Baharanchi FS, Bekhradi R. Effect of lavender inhalation on the symptoms of primary dysmenorrhea and the amount of menstrual bleeding: A randomized clinical trial. Complement Ther Med 2014;22:212-219.

Ghaderi F, Solhjou N. The effects of lavender aromatherapy on stress and pain perception in children during dental treatment: A randomized clinical trial. Complement Ther Clin Pract 2020;40:101182.

Mirhashemi A, Rasouli S, Shahi S, Chiniforush N. Efficacy of photobiomodulation therapy for orthodontic pain control following the placement of elastomeric separators: a randomized clinical trial. J Lasers Med Sci 2021;12:e8.

Fleming PS, Strydom H, Katsaros C, MacDonald L, Curatolo M, et al. Non-pharmacological interventions for alleviating pain during orthodontic treatment. Cochrane Database Syst Rev 2016;12:Cd010263.

Bergius M, Berggren U, Kiliaridis S. Experience of pain during an orthodontic procedure. Eur J Oral Sci 2002;110:92-98.

Goyal M, Khetwal D, Chawla R. Pain assessment after placing separators as well as initial archwire in orthodontic patients: a randomized clinical trial. Int J Curr Res 2018;10:64631-64634.

Burke JC, Evans CA, Crosby TR, Mednieks MI. Expression of secretory proteins in oral fluid after orthodontic tooth movement. Am J Orthod Dentofacial Orthop 2002;121:310-315.

Wu S, Chen Y, Zhang J, Chen W, Shao S, et al. Effect of low-level laser therapy on tooth-related pain and somatosensory function evoked by orthodontic treatment. Int J Oral Sci 2018;10:22.

Sfondrini MF, Vitale M, Pinheiro ALB, Gandini P, Sorrentino L, et al. Photobiomodulation and pain reduction in patients requiring orthodontic band application: randomized clinical trial. Biomed Res Int 2020;2020:7460938.

Artés-Ribas M, Arnabat-Dominguez J, Puigdollers A. Analgesic effect of a low-level laser therapy (830 nm) in early orthodontic treatment. Lasers Med Sci 2013;28:335-341.

Almallah MM, Almahdi WH, Hajeer MY. Evaluation of low level laser therapy on pain perception following orthodontic elastomeric separation: a randomized controlled trial. J Clin Diagn Res 2016;10:Zc23-Zc28.

Farzanegan F, Zebarjad SM, Alizadeh S, Ahrari F. Pain reduction after initial archwire placement in orthodontic patients: a randomized clinical trial. Am J Orthod Dentofacial Orthop 2012;141:169-173.

Krishnan V. Orthodontic pain: from causes to management--a review. Eur J Orthod 2007;29:170-179.

Fujita K. New orthodontic treatment with lingual bracket mushroom archwire appliance. Am J Orthod 1979;76:657-675.

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IssueVol 7, No 4, 2022 QRcode
SectionResearch Article(s)
DOI https://doi.org/10.18502/tim.v7i4.11485
Keywords
Lavandula Orthodontic pain Medicinal plants Pain management

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How to Cite
1.
Tazarvi Fard Shirazi M, Karandish M. The Effect of Lavender Inhalation on the Pain Perception of Orthodontic Separator Placement: An Open-Label Randomized Controlled Trial. Trad Integr Med. 2022;7(4):361-368.