Research Article

Cytotoxicity Effect of Arnebia Euchroma against Human Gastric


Introduction: Despite the reduction in the incidence of gastric cancer during the past 75 years, it remains the most common cause of death from cancer in Iran and now despite all the progress made, the 5-year survival of patients is generally 15%. Thus, improvement in current treatments seems necessary. Given the richness of Iranian medicine in ancient texts, a detailed study of the effects of medicinal plants native to Iran in particular is essential. In this research, the cytotoxicity effect of Arnebia euchoromaon AGS was reviewed.
Materials and Methods: In this study, cells were cultured in RPMI at different concentrations of Arnebia euchoroma extract (5,2,1,0.2,0.1,0.05 and 0.02 mg/ml) at intervals of 24,48 and 72 h and the number of living cells compared with the control group and cytotoxicity effect were measured by MTT assay.
Results:Within 24 hours, drug effects on reduction of cell growth of AGS in comparison to the control group at 5, 1, 0.1, 0.05 and 0.02 mg/ml were significant (P values are 0.0305, 0.0465, 0.0137, 0.0274and 0.0003, respectively). Within 48 hours, concentrations of 0.1 and 0.02 mg/ml were significant (P values are 0.0398 and 0.0143).Within 72 hours, 5, 0.05 and 0.02 mg/ml reductions were significant (P values are 0.0402, 0.0073 and 0.0349, respectively).
Conclusion: According to the results, Arnebia euchoroma significantly has no killing effect on AGS.Only in the 0.02 mg/ml concentrations the reduction was significant at three times, with a fatality rate of about 20%, which is not enough to be considered cytotoxic.

Siegel R, Naishadham D, JemalA. Cancer statistics for Hispanics/Latinos, 2012. CA: a cancer journal for clinicians. 2012;62(5):283-98.

world cancer research fund international 2013.Available from: _cancer _statistics.php [3] JemalA, Bray F, CenterMM, Ferlay J,Ward E, Forman D. Global cancer tatistics. CA: a cancer journal for clinicians. 2011;61(2):69-90.

Braunwald, Fauci, Kasper, etc. Harisson principle of internalmedicine. 18 ed.US:McGrawhill; 2012.

Fitzsimmons D, Osmond C, George S, Johnson CD.Trends in stomach and pancreatic cancer incidence and mortality inEngland and Wales,1951-2000.TheBritish journal of surgery. 2007;94(9):1162-71

noncommunicable disease units of minestry of health and medical education,national register of cancer 2008. Available cancer-report.

Devita VT, Samuel T, A RS. cancer principle and practice of oncology. US: lippincott wiliam and wilkin; 2001.

Berardi R, Scartozzi M, Romagnoli E, Antognoli S,Cascinu S. Gastric cancer treatment: a systematic review. Oncology reports. 2004;11(4):911-6.

Dickson JL, Cunningham D. Systemic treaatment of gastric cancer. European journal of astroenterology &hepatology. 2004;16(3):255-63.

Aliabadi HS, Ahmadi A. cytotoxicity and antitumor properities of amarine compound on cancer cell line (HESA-A). medical journal of islamic academy of science. 2000;13(2):55-61.

Newman DJ, Cragg GM, Snader KM. The influence of natural products upon drug discovery. Natural product reports. 2000;17(3):215-34.

Butler MS. The role of natural product chemistry in drug discovery. Journal of natural products.2004;67(12):2141-53.

Ghorbani A. Studies on pharmaceutical ethnobotany in the region of Turkmen Sahra, north of Iran (Part1):general results. Journal of ethnopharmacology.2005;102(1):58-68.

Naghibi F, Mosaddegh M, Motamed; MM, Ghorbani A. Labiatae Family in folk Medicine in Iran: from Ethnobotany to Pharmacology. Iranian Journal of PharmaceuticalResearch. 2005;4(2):63-79.

The promotion and development of traditional medicine: report of a WHO meeting. World Health Organization technical report series.1978(622):1-41.

WHO global strategy on traditional and alternative medicine. Public health reports (Washington, DC:1974). 2002;117(3):300-1.

Yeung HC. Handbook of Chinese Herbal Formula:RedwingBookCo; 1985.

Duke JA, Ayensu ES. Medicinal plants of China.Algonac Michigan:ReferencePublications Inc; 1985.

Lu G, Liao J. [Detection of the anti-cancer biological effect of naphthoquinone pigment-LIII]. Zhong xi yi jie he za zhi = Chinese journal of modern developments in traditional medicine / Zhongguo Zhong xi yi jie he yan jiu hui (chou), Zhong yi yan jiu yuan, zhu ban.1990;10(7):422-5, 390.

LuY,Mahato RI, editors. Pharmaceutical Perspectives ofCancerTherapeutics:Springer; 2009.

IssueVol 1, No 4, 2016 QRcode
SectionResearch Article(s)
Gastric adenocarcinoma Cytotoxic Arnebia euchroma In Vitro

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How to Cite
Jalali-Nadoushan M-R, Karimi M, Fattah N, Tahvil-zade M, Nazarbeigi S. Cytotoxicity Effect of Arnebia Euchroma against Human Gastric. Trad Integr Med. 2016;1(4):142-146.