Review Article

Ethnopharmacological Survey of Medicinal Plants Used in the Management of Skin-Related Conditions in Ilorin, North-Central, Nigeria

Abstract

The abundance of plants with medicinal values has been of great impact on the skincare industry in Nigeria.  However, proper documentation of plants with skincare values has not been made. Hence, this study was aimed at surveying the traditional medicinal values of some commonly used plants for the management of skin conditions by herbal practitioners in Ilorin metropolis. Ethnobotanical and demographic information of willing respondents were obtained on the most commonly used medicinal plants via semi-structured questionnaires and oral interviews. The names of the plants were further confirmed in the world flora online (www.worldfloraonline.org). A total of 57 plants species representing 30 families, were reported by 62 respondents including males (40%) and females (60%) designated as herbs sellers (32%), traditional medicine practitioners (16%), farmers (8%), housewives (11 %) and Herb sellers/traditonal medicine practitioners (33%). Their knowledge sources include inheritance (40%), training (24 %), and a combination of inheritance and training (36%). Euphorbiaceae was the most cited (11 %) plant family, the leaves were the most cited (48%) plant part used, crush to extract juice was the most widely used (51%) method of preparation, and topical application on the affected spot was the most reported (43%) method of administration. The plants mentioned in this survey were reported to have applications against psoriasis, eczema, boils, acne, measles, dandruff, rashes, and wounds. General skin conditions represented the most commonly mentioned (14%) skin condition while mastitis was the least mentioned (1%) condition.  Also, the highest (0.923) informant consensus factor (ICF) was mentioned for insect bites while the least (0.263) ICF was mentioned for general skin conditions. This study documented some of the medicinal plants that have been used to treat various skin-related conditions most of which have been mentioned in available scientific pieces of literature.

Olapade O. The use of herbs in alternative health care delivery in Nigeria. Paper delivered at the symposium organized by the National Association of botany Students, Obafemi Awolowo University, Ile-Ife 2000.

Yadav M, Khan KK, Beg M. Ethnobotanical plants used for curing skin diseases by tribals of Rewa district (Madhya Pradesh). Indian J Life Sci 2012;2:123-127.

Hay RJ, Johns NE, Williams HC, Bolliger IW, Dellavalle RP, et al. The global burden of skin disease in 2010: an analysis of the prevalence and impact of skin conditions. J Investig Dermatol 2014;134:1527-1534.

Labreche MJ, Lee GC, Attridge RT, Mortensen EM, Koeller J, et al. Treatment failure and costs in patients with methicillin-resistant Staphylococcus aureus (MRSA) skin and soft tissue infections: a South Texas Ambulatory Research Network (STARNet) study. J Am Board Fam Med 2013;26:508-517.

Stevens DL, Bisno AL, Chambers HF, Dellinger EP, Goldstein EJ, et al. Practice guidelines for the diagnosis and management of skin and soft tissue infections: 2014 update by the infectious diseases society of America. Clin Infect Dis 2014;59:e10-52.

Reszke R, Pełka D, Walasek A, Machaj Z, Reich A. Skin disorders in elderly subjects. Int J Dermatol 2015;54:e332-e338.

Dalgard FJ, Svensson Å, Gieler U, Tomas‐Aragones L, Lien L, et al. Dermatologists across Europe underestimate depression and anxiety: results from 3635 dermatological consultations. Br J Dermatol 2018;179:464-470.

Mathers CD, Lopez AD, Murray CJ. The burden of disease and mortality by condition: data, methods, and results for 2001. Global burden of disease and risk factors 2006;1;45-88.

Amin TT, Ali A, Kaliyadan F. Skin disorders among male primary school children in Al Hassa, Saudi Arabia: prevalence and socio-demographic correlates-a comparison of urban and rural populations. Rural Remote Health 2011;11:1517.

Hu J, McKoy K, Papier A, Klaus S, Ryan T, et al. Dermatology and HIV/AIDS in Africa. J Glob Infect Dis 2011;3:275-280.

Andersen K, Davis MD, Mark DP. The epidemiology of skin and skin-related diseases: a review of population-based studies performed by using the Rochester epidemiology project. Mayo Clin Proc 2013;88:1462-1467.

Misery L, Rahhali N, Duhamel A, Taieb C. Epidemiology of pruritus in France. Acta Derm Venereol 2012;92:541-542.

Nigerian Association of Dermatologists. (2017) History of the Nigerian Association of Dermatologists [Online] [Accessed November 23, 2017] https://www.nad.org.ng/history-of-thenigerian-association-of-dermatologists

Adeoluwa OA, Aderibigbe AO, Bakre AG. Evaluation of the antidepressant-like effect of Olax subscorpioidea Oliv. (Olacaceae) extract in mice. Drug Res 2015;65:306-311.

Fleischer TC, Mensah ML, Mensah AY, Komlaga G, Gbedema SY, et al. Antimicrobial activity of essential oils of Xylopia aethiopica. Afr J Tradit Complement Altern Med 2008;5:391-393.

Ngoua-Meye-Misso RL, Sima-Obiang C, Ndong JD, Ndong-Atome GR, Ondo JP, et al. Medicinal plants used in the management of cancer and other related diseases in Woleu-Ntem province, Gabon. Eur J Integr Med 2019;29:100924.

Mesfin F, Demissew S, Teklehaymanot T. An ethnobotanical study of medicinal plants in Wonago Woreda, SNNPR, Ethiopia. J Ethnobiol Ethnomedicine 2009;5:1-8.

Kupchan SM, Hemmnigway RJ, Karim A, Werner D. Tumor inhibitors. XLVII Vernodalin and Vernomygdin. Two new cytotoxic sesquiterpene lactones from Vernonia amygdalina del. J Org Chem 1969;34:3908-3911.

Ojimelukwe PC, Amaechi N. Composition of Vernonia amygdalina and its Potential Health Benefits. Int J Agric Environ Biot 2019;4:1836-1848.

Joe B, Vijaykumar M, Lokesh BR. Biological properties of curcumin-cellular and molecular mechanisms of action. Crit Rev Food Sci Nutr 2004;44:97-111.

Sonibare MA, Moody JO, Adesanya EO. Use of medicinal plants for the treatment of measles in Nigeria. J Ethnopharmacol 2009;122:268-272.

Nafiu AB, Akinwale OC, Akinfe OA, Owoyele BV, Abioye AI, et al. Histomorphological evaluation of wound healing-comparison between use of honey and vernonia amygdalina leaf juice. Nigeria Trop J Health Sci 2016;23:10-11.

El Abdellaoui S, Destandau E, Toribio A, Elfakir C, Lafosse M, et al. Bioactive molecules in Kalanchoe pinnata leaves: extraction, purification, and identification. Anal Bioanal Chem 2010; 398:1329-1338.

Aoki C, Hartati SR, Santi MR, Firdaus R, Hanafi M, et al. Isolation and identification of substances with anti-hepatitis C virus activities from Kalanchoe pinnata. Int J Pharm Pharm Sci 2014;1;6:211-215.

Nurudeen QO, Falana MB. Identification and quantification of secondary metabolites and the antimicrobial efficacy of leaves extracts of some medicinal plants. Zanco J Pure Appl Sci 2021; 33:91-106.

Okwu DE, Nnamdi FU. Two novel flavonoids from Bryophyllum pinnatum and their antimicrobial activity. J Chem Pharm Res 2011;3:1-10.

Elshamy AI, Abd‐ElGawad AM, El Gendy AE, Assaeed AM. Chemical characterization of Euphorbia heterophylla L. essential oils and their antioxidant activity and allelopathic potential on Cenchrus echinatus. L. Chem Biodivers 2019;16:e1900051.

Sharma N, Samarakoon KW, Gyawali R, Park YH, Lee SJ, et al. Evaluation of the antioxidant, anti-inflammatory, and anticancer activities of Euphorbia hirta ethanolic extract. Molecules 2014; 19:14567-14581.

Okagu IU. Bioactive constituents of methanol extract of Xylopia aethiopica (UDA) fruits from Nsukka, Enugu State, Nigeria. Open Access Libr 2018;5:1.

Tamfu AN, Ceylan O, Kucukaydin S, Ozturk M, Duru ME, et al. Antibiofilm and enzyme inhibitory potentials of two annonaceous food spices, african pepper (Xylopia aethiopica) and african nutmeg (Monodora myristica). Foods 2020;9:1768.

Aladesanmi AJ. Tetrapleura tetraptera: Molluscicidal activity and chemical constituents. Afr J Tradit Complement Altern Med 2007;4:23-36.

Khan M, Patil PA, Shobha JC. Influence of Bryophyllum pinnatum (Lim.) leaf extract on wound healing in albino rats. J Nat Remedies 2004;4:41-46.

Gberikon GM, Adeoti II, Etim EE. Antibacterial activity of Tetrapleura tetraptera fruit and stem bark extracts against Pseudomonas aeruginosa. Int Sci Res J 2015;1:1-4.

Okoronkwo NE, Echeme JO. Cholinesterase and microbial inhibitory activities of Tetrapleura tetraptera. J Nat Appl Sci 2012;4:156-163.

Liu A, Xu L, Zou Z, Yang S. Studies on chemical constituents from leaves of Cassia alata. China. Zhongguo Zhong Yao Za Zhi 2009;34:861-863.

Timothy SY, Wazis CH, Adati RG, Maspalma ID. Antifungal activity of aqueous and ethanolic leaf extracts of Cassia alata Linn. J Appl Pharm Sci 2012;2:182-185.

Sule WF, Okonko IO, Omo-Ogun S, Nwanze JC, Ojezele MO, et al. Phytochemical properties and in-vitro antifungal activity of Senna alata Linn. crude stem bark extract. J Med Plant Res 2011;5:176-183.

Ekop AS. Determination of the chemical composition of Gnetum africanum (AFANG) seeds. Pak J Nut 2007;6:40-43.

Eneh FU, Onwubiko CE, Ugochukwu GC. Phytochemical and antimicrobial activity screening of Gnetum africanum leaf extracts. Int J Herb Med 2017;5:105-109.

Rahman AU, Zareen S, Choudhary MI, Akhtar MN, Ngounou FN. Some chemical constituents of Terminalia glaucescens and their enzymes inhibition activity. Z Naturforsch B 2005; 60:347-530.

Vandita P, Amin N, Khyati P, Monisha K. Effect of phytochemical constituents of Ricinus communis, Pterocarpus santalinus, Terminalia belerica on antibacterial, antifungal and cytotoxic activity. Int J Toxicol Pharmacol Res 2013;5:47-54.

Elegami AA. Antimicrobial activity of some species of the family Combretaceae. Phytother Res 2002;16:555-561.

Salau AK, Yakubu MT, Oladiji AT. Cytotoxic activity of aqueous extracts of Anogeissus leiocarpus and Terminalia avicennioides root barks against Ehrlich Ascites Carcinoma cells. Indian J Pharmacol 2013;45:381-385.

Salih EY, Kanninen M, Sipi M, Luukkanen O, Hiltunen R, et al. Tannins, flavonoids and stilbenes in extracts of African savanna woodland trees Terminalia brownii, Terminalia laxiflora and Anogeissus leiocarpus showing promising antibacterial potential. S Afr J Bot 2017;108:370-386.

Haliński ŁP, Paszkiewicz M, Gołębiowski M, Stepnowski P. The chemical composition of cuticular waxes from leaves of the gboma eggplant (Solanum macrocarpon L.). J Food Compos Anal 2012;25:74-78.

Ajibade VA, Ibiyemi MF. The antibacterial potency of alkaloid and saponin extracts from Solanum macrocapon (Garden Egg). J Adv Microbiol 2017;59:1-5.

Odoma S, Zezi AU, Danjuma NM, Ahmed A. Analgesic and anti-inflammatory activities guided fractionation of Olax suscorpioidea leaf extract in mice and rats. Niger J Pharm Sci 2015; 14:30-43.

Adegbite OS, Akinsanya YI, Kukoyi AJ, Iyanda-Joel WO, Daniel OO, et al. Induction of rat hepatic mitochondrial membrane permeability transition pore opening by leaf extract of Olax subscorpioidea. Pharmacogn Res 2015;7:S63- S68.

Osuntokun OT, Omolola AY. Efficacy of nigerian medicinal plant (Olax subscorpioidea. Oliv.) root extract against surgical wound isolates. Am J Biochem Biotechnol 2019;2:1-11.

Park S, Nam YH, Rodriguez I, Park JH, Kwak HJ, et al. Chemical constituents of leaves of Persea americana (avocado) and their protective effects against neomycin-induced hair cell damage. Rev bras farmacogn 2020;29:739-743.

Ahmad MH, Jatau AI, Alshargi OY, Mohammed M, Muhammad S, et al. Ethnopharmacological uses, phytochemistry, pharmacology, and toxicology of Olax subscorpioidea Oliv (Olacaceae): a review. Future J Pharm Sci 2021;7:1-3.

Kouame BK, Toure D, Kablan L, Bedi G, Tea I, et al. Chemical constituents and antibacterial activity of essential oils from flowers and stems of Ageratum conyzoides from Ivory Coast. Rec Nat Prod 2018;12:160-168

Makopa M, Mangiza B, Banda B, Mozirandi W, Mombeshora M, et al. Antibacterial, antifungal, and antidiabetic effects of leaf extracts from Persea americana Mill. (Lauraceae). Biochem Res Int 2020;2020:1-10.

Yapi TA, Boti JB, Ahibo CA, Bighelli A, Casanova J, et al. Composition of leaf and stem bark oils of Xylopia villosa Chipp. J Essent Oil Res 2012;24:253-257.

Ogbonna CN, Nozaki K, Yajima H. Antimicrobial activity of Xylopia aethiopica, Aframomum melegueta and Piper guineense ethanolic extracts and the potential of using Xylopia aethiopica to preserve fresh orange juice. Afr J Biotechnol 2013;12:1993-1998.

Fategbe MA, Avwioroko OJ, Ibukun EO. Comparative biochemical evaluation of the proximate, mineral, and phytochemical constituents of Xylopia aethiopica whole fruit, seed, and pericarp. Prev Nutr Food Sci 2021;26:219-229.

Fleischer TC, Mensah ML, Mensah AY, Komlaga G, Gbedema SY, et al. Antimicrobial activity of essential oils of Xylopia aethiopica. Afr J Tradit Complement Altern Med 2008;5:391-393.

Narendhirakannan RT, Nirmala JG, Caroline A, Lincy S, Saj M, et al. Evaluation of antibacterial, antioxidant and wound healing properties of seven traditional medicinal plants from India in experimental animals. Asian Pac J Trop Biomed 2012;2:S1245-S1253.

Ndamitso MM, Mustapha S, Etsuyankpa MB, Ajai AI, Mathew JT. Evaluation of chemical composition of Acacia nilotica seeds. FUW Trends Sci Technol J 2017;2:927-931

Hwang YS, Chang BY, Kim DS, Cho HK, Kim SY. Effects of the Syzygium aromaticum L. extract on antioxidation and inhibition of matrix metalloproteinase in human dermal fibroblast. Asian Pac J Trop Biomed 2019;9:53-59.

Ali A, Akhtar N, Khan BA, Khan MS, Rasul A, et al. Acacia nilotica: a plant of multipurpose medicinal uses. J Med Plant Res 2012;6:1492-1496.

Sharma AK, Kumar A, Yadav SK, Rahal A. Studies on antimicrobial and immunomodulatory effects of hot aqueous extract of Acacia nilotica L. leaves against common veterinary pathogens. Vet Med Int 2014;2014:1-9

Al-Aamri MS, Al-Abousi NM, Al-Jabri SS, Alam T, Khan SA. Chemical composition and in-vitro antioxidant and antimicrobial activity of the essential oil of Citrus aurantifolia L. leaves grown in Eastern Oman. J Taibah Univ Med Sci 2018;13:108-112.

Lemes RS, Alves CC, Estevam EB, Santiago MB, Martins CH, et al. Chemical composition and antibacterial activity of essential oils from Citrus aurantifolia leaves and fruit peel against oral pathogenic bacteria. An Acad Bras Cienc 2018;90:1285-1292.

Fonseca MA, Karpe AN, Keerthi P, Mendes RM. Fruit peel soap and its antibacterial properties in skincare. Int J Curr Pharm Res 2019;11:17-20.

Balasundram N, Sundram K, Samman S. Phenolic compounds in plants and agri-industrial by-products: Antioxidant activity, occurrence, and potential uses. Food Chem 2006;99:191-203.

Gill LS. Ethnomedical Uses of Plants in Nigeria. Benin: Uniben Press, University of Benin. 1992.

Tekwu EM, Bosompem KM, Anyan WK, Appiah-Opong R, Owusu KB, et al. In vitro assessment of anthelmintic activities of Rauwolfia vomitoria (Apocynaceae) stem bark and roots against parasitic stages of Schistosoma mansoni and cytotoxic study. J Parasitol Res 2017;11-12: 1-11.

Emencheta SC, Enweani BI, Oli AN, Ibezim EC, Imanyikwa IE. Antimicrobial evaluation of plant parts of Rauwolfia vomitoria. J Complement Med Res 2020;11-20.

Wadgama AA, Mandade RJ, Jangid PR. Therapeutic review on medicinal plant Merremia dissecta. Int J Recent Sci Res 2020;11:37466-37470.

Austin DF. Merremia dissecta, (Convolvulaceae): Condiment, medicine, ornamental and weed: a review. Econ Bot 2007;61:109-120.

Meybodi MS. A review on pharmacological activities of Citrullus colocynthis (L.) Schrad. Asian J Res Rep Endocrinol 2020;3:25-34.

Mohammed AA. In-vitro antibacterial, antifungal, antibiofilm, and antioxidant potentials of isopimpinellin recovered from Citrullus colocynthis. Int J Pharm Pharm Sci 2016;8:117-122.

Khallouki F, Younos C, Soulimani R, Bessière JM. Chemical composition of the essential oils of Annona cuneata L. and Annona senegalensis Pers. stem barks. Flavour Fragr J 2002;17; 398-400.

Younoussa L, Nukenine EN, Danga SP, Esimone CO. Repellent activity of the creams formulated from Annona senegalensis and Boswellia dalzielii leaf fractions and essential oils against Anopheles gambiae (Diptera: Culicidae). Asian Pac J Trop Dis 2016;6:973-978.

Anthony O, Said O, Hamis I, Ame M, Odalo O. Assessment of antifungal activity of Annona senegalensis plant parts of malassezia globosa. Nat Prod Res 2017;5:1-5

Sun J, Ding ZQ, Gao Q, Xun H, Tang F, et al. Major chemical constituents of bamboo shoots (Phyllostachys pubescens): qualitative and quantitative research. J Agric Food Chem 2016; 64:2498-2505.

Ghanbarinasab Z, Hosseini-Bensenjan M, Ziabari EZ, Aminnia S, Borazjani R, et al. Topical Bambusa vulgaris extract enhances wound healing in cutaneous leishmaniasis. J Pathog 2021; 7860474.

Mao QQ, Xu XY, Cao SY, Gan RY, Corke H, et al. Bioactive compounds and bioactivities of ginger (Zingiber officinale Roscoe). Foods 2019;8:185.

Suliman RS, Wai L, Hanif NM, Yusuf E, Asmani F. Comparative studies of Zingiber officinale leaves and rhizomes on the antibacterial effect. Int J Pharm Anal Res 2014;3:262-268.

Zubair MF, Atolani O, Ibrahim SO, Adebisi OO, Hamid AA, et al. Chemical constituents and antimicrobial properties of Phyllanthus amarus (Schum & Thonn). Bayero J Pure Appl Sci 2017;10:238-246.

Adegoke AA, Iberi PA, Akinpelu DA, Aiyegoro OA, Mboto CI. Studies on phytochemical screening and antimicrobial potentials of Phyllanthus amarus against multiple antibiotic-resistant bacteria. Int J Appl Res Nat Prod 2010;3:6-12.

Sonibare MA, Ogunwande IA, Walker TM, Setzer WN, Soladoye MO, et al. Volatile constituents of Ficus exasperata leaves. Nat Prod Commun 2006;1:763-765.

Obuekwe IS, Okoyomo EP, Anka US. Effect of plant extract combinations on some bacterial pathogens. J Appl SCI Environ Manag 2020;24:627-632.

Kimtun P, Yunu T, Paichid N, Klomklao S, Prasertsan P, et al. Study of chemical constituents from palm fruit (Elaeis guineensis) after harvesting and the application of palm lipase for biodiesel production. ASEAN J Sci Technol 2017;20:1-9.

Anyanji VU, Mohamed S, Zokti JA, Ado MA. Anti-inflammatory properties of oil palm leaf (Elaeis guineensis Jacq.) extract in aged rats. Int J Pharm Pharm Sci 2013;5:134-136.

Burkill HM. Brief descriptions and details of the buses of over 4,000 plants. The useful plants of West Tropical Africa. Royal botanical gardens 2004;4:969.

Kirbag S, Erecevit P, Zengin F, Guvenc AN. Antimicrobial activities of some Euphorbia species. Afr J Tradit Complement Altern Med 2013;10:305-309.

Elusiyan CA, Ayoade O, Adeloye AO, Olorunmola FO, Agbedahunsi JM, et al. Antisickling and radical scavenging activities of selected medicinal plants and compounds from Mitracarpus villosus (Sw.) DC. Cham Eur J Med Plant 2018;24:1-10.

Ekalu A. Medicinal uses, phytochemistry, and pharmacological activities of mitracarpus species (rubiaceae): a review. Sci Afr 2021;11:e00692.

Fabri RL, Grazul RM, Carvalho LO, Coimbra ES, Cardoso GM, et al. Antitumor, antibiotic and antileishmanial properties of the Pyranonaphthoquinone Psychorubrin from Mitracarpus frigidus. Anais da Academia Brasileira de Ciências 2012;84:1081-1090.

Zhao GT, Liu JQ, Deng YY, Li HZ, Chen JC, et al. Cucurbitane-type triterpenoids from the stems and leaves of Momordica charantia. Fitoterapia 2014;95:75-82.

Ma L, Yu AH, Sun LL, Gao W, Zhang MM, et al. Two new bidesmoside triterpenoid saponins from the seeds of Momordica charantia L. Molecules 2014;19:2238-2246.

Ahmad Z, Zamhuri KF, Yaacob A, Siong CH, Selvarajah M, et al. In vitro anti-diabetic activities and chemical analysis of polypeptide-k and oil isolated from seeds of Momordica charantia (bitter gourd). Molecules 2012;17:9631-9640.

Agyare C, Adarkwa-Yiadom M, Osei-Asante S. Medicinal plants used for treatment of wounds and skin infections: assessment of wound healing and antimicrobial properties of Mallotus oppositifolius and Momordica charantia. Int J Herb Med 2014;6:50-58.

Ata A, Udenigwe CC, Matochko W, Holloway P, Eze MO, et al. Chemical constituents of Nauclea latifolia and their anti-GST and anti-fungal activities. Nat Prod Commun 2009;4:1185-1188.

Okiei WO, Ogunlesi M, Osibote EA, Binutu MK, Ademoye MA. Comparative studies of the antimicrobial activity of components of different polarities from the leaves of Nauclea latifolia. Res J Med Plant 2011;5:321-329.

Adeyemi MA, Ekunseitan DA, Abiola SS, Dipeolu MA, Egbeyale LT, et al. Phytochemical analysis and GC-MS determination of Lagenaria breviflora R. fruit. Int J Pharmacogn Phytochem Res 2017;9:1045-1050.

Olorunnisola OS, Afolayan AJ, Adetutu A. Sub-chronic administration of methanolic whole fruit extract of Lagenaria breviflora (Benth.) Roberty induces mild toxicity in rats. Pharmacogn Mag 2015;11:S516-S521.

Balogun ME, Ajayi AF, Oji OJ, Besong EE, Finbarrs-Bello E, et al. Toxicological and biochemical studies of ethanolic fruit extract of Adenopus breviflorus (Lagenaria breviflora Roberty) in male albino Wistar rats. Am J Phyt Clin Ther 2014;2:1112-1123.

Félicienne A, Isabelle ST, Pascal TA, Espérance M, Rose KE, et al. The aqueous extract of the root bark of Psorospermum febrifugum Spach effectively corrects anaemia. experimental study on Wistar rats. J Appl Biosci 2019;27:14137-14146.

Namukobe J, Sekandi P, Byamukama R, Murungi M, Nambooze J, et al. Antibacterial, antioxidant, and sun protection potential of selected ethno medicinal plants used for skin infections in Uganda. Trop Med Health 2021;49:1-0.

Ojokuku SA, Okunowo WO, Apena A. Evaluation of the chemical composition of Khaya grandifoliola and Ficus capensis. J Med Plant Res 2010;4:1126-1129.

Quartey AK, Orman E, Mireku-Gyimah NA, Goku PE, Alidu F, et al. Evaluating the antibacterial, antioxidant and wound healing properties of the stem bark extract of Khaya grandifoliola (Welw) CDC (Meliaceae) (African mahogany). J Med Plant Res 2020;14:604-612.

Kodati DR, Burra S, Kumar GP. Evaluation of wound healing activity of methanolic root extract of Plumbago zeylanica L. in Wistar albino rats. Asian J Plant Sci 2011;1:26-34.

Tebeka T. Studies on antioxidant and antimicrobial activities of Plumbago zeylanica Linn. traditionally used for the treatments of intestinal warms and skin diseases in Ethiopia. Res J Med Plant 2015;9:252-263.

Coker ME, Oaikhena AO, Ajayi TO. Antimicrobial activity of extracts and fractions of Euphorbia lateriflora (Schum. and Thonn) on microbial isolates of the urinary tract. Saudi J Biol Sci 2021;28:4723-4731.

Falana MB, Nurudeen QO. phytochemical screening and in vitro antimicrobial activities of Euphorbia Lateriflora on selected pathogens. Iraqi J Sci 2022;63:1402-1412.

Elufioye TO, Olaifa O. Pharmacognostic evaluation of the leaves and stem bark of Euphorbia lateriflora schum & thonn (Euphorbiaceae). Niger J Nat Prod Med 2014;18:18-23

Ighodaro OM, Agunbiade SO, Omole JO, Kuti OA. Evaluation of the chemical, nutritional, antimicrobial and antioxidant-vitamin profiles of Piliostigma thonningii leaves. Res J Med Plant 2012;6:537-543.

Ozolua RI, Alonge P, Igbe I. Effects of leaf extracts of Piliostigma thonningii schum on aortic ring contractility and bleeding time in rats. J Herbs Spices Med Plants 2010;15:326-333.

Kayode OT, Yakubu MT. Parquetina nigrescens leaves: chemical profile and influence on the physical and biochemical indices of sexual activity of male Wistar rats. J Integr Med 2017; 15:64-76.

Ayoola AO, Akinloye O, Oguntibeju OO, Oke JM, Odetola AA. Antioxidant activities of Parquetina nigrescens. Afr J Adv Biotechnol 2011;10:4920-4925.

Sokefun OO, Eleyowo OO, Avungbeto MO. In vitro antioxidant and antibacterial activity of Bridelia atroviridis (Arasado). J Complement Med Res 2017;17:1-7.

Ribeiro PR, de Castro RD, Fernandez LG. Chemical constituents of the oilseed crop Ricinus communis and their pharmacological activities. Ind Crops Prod 2016;91:358-376.

Abew B, Sahile S, Moges F. In vitro antibacterial activity of leaf extracts of Zehneria scabra and Ricinus communis against Escherichia coli and methicillin resistance Staphylococcus aureus. Asian Pac J Trop Biomed 2014;4:816-820.

Abd-Ulgadir KS, Suliman SI, Zakria IA, Hassan NE. Antimicrobial potential of methanolic extracts of Hibiscus sabdariffa and Ricinus communis. Adv Med Plant Res 2015;3:18-22.

Jeyaseelan EC, Jashothan PJ. In vitro control of Staphylococcus aureus (NCTC 6571) and Escherichia coli (ATCC 25922) by Ricinus communis L. Asian Pac. J Trop Biomed 2012;2:717-721.

Naz R, Bano A. Antimicrobial potential of Ricinus communis leaf extracts in different solvents against pathogenic bacterial and fungal strains. Asian Pac J Trop Biomed 2012;2:944-947.

El-Saber Batiha G, Magdy Beshbishy A, G Wasef L, Elewa YH, A Al-Sagan A, et al. Chemical constituents and pharmacological activities of garlic (Allium sativum L.): a review. Nutrients 2020;12:872.

Capasso A. Antioxidant action and therapeutic efficacy of Allium sativum L. Molecules 2013;18:690-700.

Majewski M. Allium sativum: facts and myths regarding human health. Rocz Panstw Zakl. Hig 2014;65:1-8.

Goossens A. Contact-allergic reactions to cosmetics. J Allergy 2011;2011:467071.

Mukherjee P, Maity N, Nema N, Sarkar B. Bioactive compounds from natural resources against skin aging. Phytomedicine 2011;19:64-73.

Ata A, Gale EM, Samarasekera R. Bioactive chemical constituents of Caesalpinia bonduc (Fabaceae). Phytochem Lett 2009;2:106-109.

Simin K, Khaliq-Uz-Zaman SM, Ahmad VU. Antimicrobial activity of seed extracts and bondenolide from Caesalpinia bonduc (L.) Roxb. Phytother Res 2001;15:437-440.

Srinivasan RM, Chandrasekar MJ, Nanjan MJ, Suresh B. Antioxidant activity of Caesalpinia digyna root. J Ethnopharmacol 2007;113:284-291.

Ashokkumar K, Vellaikumar S, Murugan M, Dhanya MK, Aiswarya S, et al. Chemical composition of Ocimum gratissimum essential oil from the South Western Ghats, India. Curr Opin Food Sci C 2020;1:27-30.

Mbakwem-Aniebo C, Onianwa O, Okonko IO. Effects of Ocimum gratissimum leaves on common dermatophytes and causative agent of Pityriasis versicolor in rivers state, Nigeria J Microbiol Res 2012;2:108-113.

Schmidt E, Bail S, Buchbauer G, Stoilova I, Atanasova T, et al. Chemical composition, olfactory evaluation and antioxidant effects of essential oil from Mentha x piperita. Nat Prod Commun 2009;4:1107-1112

Satmi FR, Hossain MA. In vitro antimicrobial potential of crude extracts and chemical compositions of essential oils of leaves of Mentha piperita L native to the Sultanate of Oman. Pac Sci Rev 2016;18:103-106.

Pramila DM, Xavier R, Marimuthu K, Kathiresan S, Khoo ML, et al. Phytochemical analysis and antimicrobial potential of methanolic leaf extract of peppermint (Mentha piperita: Lamiaceae). J Med Plant Res 2012;6:331-533.

Furtado AA, Torres-Rêgo M, Lima MC, Bitencourt MA, Estrela AB, et al. Aqueous extract from Ipomoea asarifolia (Convolvulaceae) leaves and its phenolic compounds have anti-inflammatory activity in murine models of edema, peritonitis and air-pouch inflammation. J Ethnopharmacol 2016;192:225-235.

Meira M, Silva EP, David JM, David JP. Review of the genus Ipomea: traditional uses, chemistry and biological activities. Rev Bras 2012;22:682-713.

Vergara-Jimenez M, Almatrafi MM, Fernandez ML. Bioactive components in Moringa oleifera leaves protect against chronic disease. Antioxidants 2017;6:91.

Hukkeri VI, Nagathan CV, Karadi RV, Patil BS. Antipyretic and wound healing activities of Moringa oleifera Lam. in rats. Indian J Pharm Sci 2006;68:124-126.

Lawal OA, Kasali AA, Opoku AR, Ojekale AB, Oladimeji OS, et al. Chemical composition and antibacterial activity of essential oil from the leaves of Aframomum melegueta (Roscoe) K. Schum from Nigeria. J Essent Oil-Bear Plants 2015;18:222-229.

Osuntokun OT. Aframomum melegueta (grains of paradise). Ann Microbiol Infect Dis 2020; 3:1-6.

Falana MB, Bankole MO, Afolabi RO. Differential antimicrobial effects of conventional and ethnobotanical extracts from Vitellaria paradoxa roots, barks and leaves. Br Microbiol Res J 2015;6:54-60.

Awotedu OL, Ogunbamowo PO, Ariwoola OS, Chukwudebe EP. Phytochemical and phytomineral status of Spigelia anthelmia Linn leaves. Int J Bio Res Rev 2020;29:33-40

Danlami U, Cecilia OE, Ifeanyi OM. Evaluation of the phytochemicals and antimicrobial activities of the ethanolic, hexane and ethyl acetate extracts of Spigelia anthelmia leaves. Int J Pharm Chem 2017;3:29.

Edeoga HO, Okwu DE, Mbaebie BO. Phytochemical constituents of some Nigerian medicinal plants. Afr J Biotechnol 2005;4:685-688.

Erharuyi O, Falodun A, Langer P. Medicinal uses, phytochemistry and pharmacology of Picralima nitida (Apocynaceae) in tropical diseases: a review. Asian Pac J Trop Med 2014;7:1-8.

Nassar MI, Gaara AH, El-Ghorab AH, Farrag A, Shen H, et al. Chemical constituents of clove (Syzygium aromaticum, Fam. Myrtaceae) and their antioxidant activity.

Rev Latinoam Quím 2007;35:47.

International Organization for Standardization. Oil of clover leaf [Syzygium aromaticum (Linnaeus) Merril and Perry, syn. Eugenia caryophyllus (Sprengel) Bullock and S. Harrison]. ISO‐Directive 3141/1997, Geneva, Switzerland, 2002.

Hwang YS, Chang BY, Kim DS, Cho HK, Kim SY. Effects of the Syzygium aromaticum L. extract on antioxidation and inhibition of matrix metalloproteinase in human dermal fibroblast. Asian Pac J Trop Biomed 2019;9:53-59.

Gbenou JD, Ahounou JF, Akakpo HB, Laleye A, Yayi E, et al. Phytochemical composition of Cymbopogon citratus and Eucalyptus citriodora essential oils and their anti-inflammatory and analgesic properties on Wistar rats. Mol Biol Rep 2013;40:1127-1134.

Li M, Liu B, Bernigaud C, Fischer K, Guillot J, et al. Lemongrass (Cymbopogon citratus) oil: A promising miticidal and ovicidal agent against Sarcoptes scabiei. PLOS Negl Trop Dis 2020; 14:e0008225.

Wisdom NN, Bassey EE, Jelani FB, Ishaku GA, Uwem UM, et al. Biochemical Studies of Ocimum sanctum and Olax subscorpioidea leaf extracts. J Pharm Res Int 2016;12:1-9.

Ogboru RO, Akideno LO, Owoeye EA. Chemical composition and medicinal potentials of the bark of Erythrophleum ivorense A. Chev J Biosci Biotechnol Discv 2017;2:15-20.

Akanji OC, Sonibare MA. Evaluation of wound healing activity of Erythrophleum suaveolens (Guill. & Perr.) brenan and Moringa oleifera Lam. on infected albino rats. European J Med Plant Res 2015;67-76.

Christy AO, Bamidele A. Phytochemical, mineral contents and proximate compositions of the stem bark of Erythrophleum Suaveolens brenan (Guill. & Perr.). IRE J 2020;3:89-97.

Mahmood AA, Sidik K, Salmah I. Wound healing activity of Carica papaya L. aqueous leaf extract in rats. Int J Mol Med Adv Sci 2005;1:398-401.

Niranjan A, Prakash D. Chemical constituents and biological activities of turmeric (Curcuma longa l.)-a review. J Food Sci Technol 2008;45:109.

Thangapazham RL, Sharma A, Maheshwari RK. Beneficial role of curcumin in skin diseases. Adv Exp Med Biol 2007;595: 343-357.

Fadus MC, Lau C, Bikhchandani J, Lynch HT. Curcumin: An age-old anti-inflammatory and anti-neoplastic agent. J Tradit Complement 2017;7:339-346.

Gupta A, Ansari S, Gupta S, Narwani M, Gupta M, et al. Therapeutics role of neem and its bioactive constituents in disease prevention and treatment. J Pharmacogn Phytochem 2019;8:680-691.

Falana MB, Nurudeen QO. Analysis of secondary metabolites and in vitro evaluation of extracts of Carica papaya and Azadirachta indica leaves on selected human pathogens. Not Sci Biol 2020;12:57-73.

Pandey IP, Ahmed SF, Chhimwal S, Pandey S. Chemical composition and wound healing activity of volatile oil of leaves of Azadirachta indica A. Juss. Adv Pure Appl Chem 2012;1:62-66.

Cavalcante GS, Morais SM, André WP, Araújo-Filho JV, Muniz CR, et al. Chemical constituents of Calotropis procera latex and ultrastructural effects on Haemonchus contortus. Rev Bras DE Parasitol Vet 2020;29:e001320.

Aderounmua AO, Omonisib AE, Akingbasotec JA, Makanjuolad M, Bejide R, et al. Wound-healing and potential anti-keloidal properties of the latex of Calotropis procera (Aiton) Asclepiadaceae in rabbits. Afr J Tradit Complement Altern Med 2013;10:574-579.

EL-Kamali HH. Medicinal plants in east and central Africa: challenges and constraints. Ethnobot leafl 2009;2009:12.

Templer SJ, Brito MO. Bacterial skin and soft tissue infections. Hospital physician 2009; 26:9-16.

Mathieu D, Linke JC, Wattel F. Non Healing Wounds. In: Handbook on hyperbaric medicine, Mathieu DE (ed). Springer. Netherlands 2006; p 812.

Menke NB, Ward KR, Witten TM, Bonchev DG, Diegelmann RF. Impaired wound healing. Clin Dermatol 2007;25:19-25.

Borokini TI, Ighere DA, Clement M, Ajiboye T, Alowonle A. Ethnobiological survey of traditional medicine practices in Oyo State. J Med Plant Res 2013;1:1-6.

Weldegerima B. Review on the importance of documenting ethnopharmacological information on medicinal plants. Afr J Pharm Pharmacol 2009;3:400-403.

Sofowora EA. Plants In African Traditional Medicine-An Overview. In: W.C. Evans, (Eds.), Trease and Evans Pharmacognosy. 15th ed. Saunders an imprint of Elsevier. India 2008; pp 488-496.

Ajibesin KK. Ethnobotanical survey of plants used for skin diseases and related ailments in Akwa Ibom State, Nigeria. Ethnobot Res Appl 2012;10:463-522.

Abbasi AM, Khan MA, Ahmad M, Zafar M, Jahan S, et al. Ethnopharmacological application of medicinal plants to cure skin diseases and in folk cosmetics among the tribal communities of North-West Frontier Province, Pakistan. J Ethnopharmacol 2010;128:322-335.

Passero LF, Laurenti MD, Santos Gomes G, Soares Campos BL, Sartorelli BP, et al. In vivo antileishmanial activity of plant based secondary metabolites. In: Fighting Multidrug Resistance with Herbal Extracts, Essential Oils and Their Components. 1st ed. Oxford: Academic Press. 2013; pp 95 107.

Gbadamosi IT, Egunyomi A. Ethnobotanical survey of plants used for the management of sexually transmitted infections in Ibadan, Nigeria. Ethnobotany Res Appl 2014;12:659-669.

Erinoso SM, Fawibe OO, Oyelakin AS, Ajiboye AA, Agboola DA. Herbal recipes used for the traditional management of infantile dermatitis in Odeda, Southwestern Nigeria. Afr J Tradit Complement Altern Med 2016;13:33-43.

Mwangi VI, Mumo RM, Nyachieo A, Onkoba N. Herbal medicine in the treatment of poverty associated parasitic diseases: A case of sub-Saharan Africa. J Herb Med 2017;10:1-7.

Silambarasan R, Sureshkumar J, Krupa J, Amalraj S, Ayyanar M. Traditional herbal medicines practiced by the ethnic people in Sathyamangalam forests of Western Ghats, India. Eur J Integr Med 2017;16:61 72.

Taylor L. The Healing Power of Rainforest Herbs. Square one Publishers, Inc 2004

Abdillahi HS, Van Staden J. Application of medicinal plants in maternal healthcare and infertility: a South African perspective. Planta Med 2013;79:591-599.

Batawila K. Antifungal activities of five Combretaceae used in Togolese traditional medicine. Fitoterapia 2005;76:264-268.

Bussmann RW, Glenn A. Medicinal plants used in Northern Peru for reproductive problems and female health. J Ethnobiol Ethnomedicine 2010;6:1-2.

Nordeng H, Al-Zayadi W, Diallo D, Ballo N, Paulsen BS. Traditional medicine practitioners’ knowledge and views on treatment of pregnant women in three regions of Mali. J Ethnobiol Ethnomedicine 2013;9:1-10.

Files
IssueVol 8, No 1, 2023 QRcode
SectionReview Article(s)
DOI https://doi.org/10.18502/tim.v8i1.12404
Keywords
Dermatophytes Eczema Ethnobotanical Psoriasis Skincare

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
1.
Falana M, Nurudeen Q, Salimon S, Abubakar I. Ethnopharmacological Survey of Medicinal Plants Used in the Management of Skin-Related Conditions in Ilorin, North-Central, Nigeria. Trad Integr Med. 2022;8(1):56-76.