Effects of Galbanum Oil on Patients with Knee Osteoarthritis: A Randomized Controlled Clinical Trial
Knee osteoarthritis is considered as a major public health issue causing chronic disability worldwide with the increasing number of aging people. Many sufferers with knee osteoarthritis are using complementary and alternative medicine including herbal drug, herbal patch, etc. This research aimed to compare the efficacy of galbanum oil in the management of knee osteoarthritis with diclofenac gel using parallel randomized controlled design. In this randomized controlled trial (RCT), 32 patients with chronic knee pain due to osteoarthritis were randomly allocated into two equal groups. The intervention group received topical galbanum oil and control group received topical diclofenac gel. The drugs were given for 1 month, 3 times per day. Outcomes were assessed using Persian version of Western Ontario McMaster University Osteoarthritis Index (WOMAC) and visual analog scale (VAS). No statistically significant difference was observed between the topical galbanum oil and topical diclofenac gel regarding knee pain, morning stiffness and physical function over the 1- and 2-months follow-up period. It seems that using topical galbanum oil is clinically effective for patients suffering from knee osteoarthritis in order to decrease their pain, morning stiffness and limited function; its effect is comparable with topical diclofenac gel. Considering lesser side effects of galbanum and its herbal base, it may be a better choice compared to topical diclofenac in management of the pain of knee osteoarthritis at least in short term.
Dougados M. Osteoarthritis: more evidence for non-pharmacological OA therapy. Nat Rev Rheumatol 2009; 5: 597-598.
Felson DT. Developments in the clinical understanding of osteoarthritis. Arthritis Res Ther2009; 11: 203.
Hochberg MC, Altman RD, Brandt KD, Clark BM, Dieppe PA, Griffin MR, et al. Guidelines for the medical management of osteoarthritis. Part II. Osteoarthritis of the knee. American College of Rheumatology. Arthritis Rheum 1995; 38: 1541-1546.
Hungin AP, Kean WF. Nonsteroidal anti- inflammatory drugs: overused or underused in osteoarthritis? Am J Med 2001; 110: 8S-11S.
Petrella RJ, DiSilvestro MD, Hildebrand C. Effects of hyaluronate sodium on pain and physical functioning in osteoarthritis of the knee: a randomized, double-blind, placebo-controlled clinical trial. Arch Intern Med 2002; 162: 292-298.
Altman RD. Practical considerations for the pharmacologic management of osteoarthritis. Am J Manag Care 2009; 15: S236-S243.
Ameye LG, Chee WS. Osteoarthritis and nutrition.From nutraceuticals to functional foods: a systematic review of the scientific evidence. Arthritis Res Ther 2006; 8: R127.
Buffum M, Buffum JC. Nonsteroidal anti- inflammatory drugs in the elderly. Pain Manag Nurs 2000; 1: 40-50.
Miller MJ, Mehta K, Kunte S, Raut V, Gala J, Dhumale R, et al. Early relief of osteoarthritis symptoms with a natural mineral supplement and a herbomineral combination: A randomized controlled trial [ISRCTN38432711]. J Inflamm (Lond) 2005; 2: 11.
Felson DT, McAlindon TE. Glucosamine and chondroitin for osteoarthritis: to recommend or not to recommend? Arthritis Care Res 2000; 13: 179-182.
Long L, Soeken K, Ernst E. Herbal medicines for the treatment of osteoarthritis: a systematic review. Rheumatology 2001; 40: 779-93.
Teekachunhatean S, Kunanusorn P, Rojanasthien N, Sananpanich K, Pojchamarnwiputh S, Lhieochaiphunt S, et al. Chinese herbal recipe versus diclofenac in symptomatic treatment of osteoarthritis of the knee: a randomized controlled trial [ISRCTN70292892]. BMC Complement Altern Med 2004; 4: 19.
Zargari A. Medicinal plants. University of Tehran Publications. Tehran, Iran 1984. [In Persian].
Ghasemi Y, Faridi P, Mehregan I, Mohagheghzadeh A. Ferula gummosa fruits: an aromatic antimicrobial agent. Chem Nat Compd 2005; 41: 311-314.
Jalali HT, Ebrahimian ZJ, Evtuguin DV, Neto CP.Chemical composition of oleo-gum-resin from Ferula gummosa. Industrial Crops and Products 2011; 33: 549-553.
Asili J, Sahebkar A, Fazly Bazzaz BS, Sharifi S, Iranshahi M. Identification of essential oil components of ferula badrakema fruits by GC-MS and 13C-NMR methods and evaluation of its antimicrobial activity. Journal of Essential Oil Bearing Plants 2009; 12: 7-15.
Maggi F, Cecchini C, Cresci A, Coman MM, Tirillini B, Sagratini G, et al. Chemical composition and antimicrobial activity of the essential oil from Ferula glauca L. (F. communis L. subsp. glauca) growing in Marche (central Italy). Fitoterapia 2009;80: 68-72.
Iranshahi M, Fata A, Emami B, Shahri B, Bazzaz B. In vitro antifungal activity of polysulfides-rich essential oil of Ferula latisecta fruits against human pathogenic dermatophytes. Nat Prod Commun 2008; 3: 1543-1546.
Tepe B, Daferera D, Sokmen A, Sokmen M, Polissiou M. Antimicrobial and antioxidant activities of the essential oil and various extracts of Salvia tomentosa Miller (Lamiaceae). Food Chem 2005; 90: 333-340.
Appendino G, Mercalli E, Fuzzati N, Arnoldi L, Stavri M, Gibbons S, et al. Antimycobacterial coumarins from the sardinian giant fennel (Ferula communis). J Nat Prod 2004; 67: 2108-2110.
Mossa JS, El-Feraly FS, Muhammad I.Antimycobacterial constituents from Juniperus procera, Ferula communis and Plumbago zeylanica and their in vitro synergistic activity with isonicotinic acid hydrazide. Phytother Res 2004;18: 934-937.
Mandegary A, Sayyah M, Heidari MR.Antinociceptive and anti-inflammatory activity of the seed and root extracts of ferula gummosa boiss in mice and rats. DARU J Pharm Sci 2004; 12:58-62.
Fatehi M, Farifteh F, Fatehi-Hassanabad Z.Antispasmodic and hypotensive effects of Ferula asafoetida gum extract. J Ethnopharmacol 2004; 91:321-324.
Sayyah M, Mandgary A, Kamalinejad M.Evaluation of the anticonvulsant activity of the seed acetone extract of Ferula gummosa Boiss. against seizures induced by pentylenetetrazole and electroconvulsive shock in mice. J Ethnopharmacol 2002; 82: 105-109.
Dehghan G, Shafiee A, Ghahremani MH, Ardestani SK, Abdollahi M. Antioxidant potential of various extracts from ferula szovitsiana. In relation to their phenolic content. Pharmaceutical Biology 2007; 45: 691-699.
Fabricant DS, Farnsworth NR. The value of plants used in traditional medicine for drug discovery. Environ Health Perspect 2001; 109: 69-75.
Farzaei MH, Farzaei F, Gooshe M, Abbasabadi Z, Rezaei N, Abdolghaffari AH. Potentially effective natural drugs in treatment for the most common rheumatic disorder: osteoarthritis. Rheumatol Int 2015; 35: 799-814.
Tsai CC, Chou YY, Chen YM, Tang YJ, Ho HC, Chen DY. Effect of the herbal drug guilu erxian jiao on muscle strength, articular pain, and disability in elderly men with knee osteoarthritis. Evid Based Complement Alternat Med 2014; 2014:297458.
Gemmell HA, Jacobson BH, Hayes BM. Effect of a topical herbal cream on osteoarthritis of the hand and knee: a pilot study. J Manipulative Physiol Ther 2003; 26: e15.
Santos FA, Rao VS. Antiinflammatory and antinociceptive effects of 1,8-cineole a terpenoid oxide present in many plant essential oils. Phytother Res 2000; 14: 240-244.
|Issue||Vol 1, No 3, 2016|
|Ferula gummosa Galbanum oil Knee osteoarthritis Pain Morning stiffness|
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