Review Article

Bunium persicum: A Review of Ethnopharmacology, Phytochemistry, and Biological Activities

Abstract

Bunium persicum (Boiss) B. Fedtsh (Apiaceae, Persian name: Zireh Kermani) has been used to treat various diseases in traditional and folkloric medicine including gastrointestinal, respiratory, nasopharyngeal, cardiac, ocular, neurological, rheumatological and urinary tract diseases. Its essential oil contains different monoterpenes, sesquiterpenes and phenyl propenes. Other chemical constituents identified in B. persicum are phenolic compounds, fatty acids, carboxylic acids, and carbohydrates. Wide range of biological and pharmacological activities including antioxidant, analgesic, anti-inflammatory, acetylcholinesterase inhibitory, anticonvulsant, HMG-CoA reductase inhibitory, anti-pancreatic lipase, anticancer, antidiabetic, antihistamine, antidiarrheal, antispasmodic, antihematoxic, antityrosinase and antimicrobial activities have been reported from this plant in modern medicine. This article summarizes comprehensive information attributing traditional uses, phytochemistry, and pharmacological activities of Zireh Kermani.

Thappa RK, Ghosh S, Agarwal SG. Comparative studies on the major volatiles of kala zira (Bunium persicum Seed) of wild and cultivated sources. Food Chem 1991;41:129-134.

Mozaffarian V. Identification of medicinal and aromatic plants of Iran. 2nd ed. Farhange moaser. Tehran 2013; pp 1152-1153.

Rahimi R, Shams-Ardekani M, Abdollahi M. A review of the efficacy of traditional Iranian medicine for inflammatory bowel disease. World J Gastroenterol 2010;16:4504-4514.

Hajhashemi V, Sajjadi SE, Zomorodkia M. Antinociceptive and anti-inflammatory activities of Bunium persicum essential oil, hydroalcoholic and polyphenolic extracts in animal models. Pharm Biol 2011;49:146-151.

Rinchen T, Pant S. Ethnopharmacological uses of plants among inhabitants surrounding Suru and Zanskar valleys of cold desert, ladakh. Int J Pharm Biol Sci 2014;5:486-494.

Shinwari ZK, Gilani SS. Sustainable harvest of medicinal plants at Bulashbar Nullah, Astore (northern Pakistan). J Ethnopharmacol 2003;84:289-298.

Abduganiev BE, Rashkes YV, Pulgar VN. GC-MS analysis of the essential oil of the fruit of Bunium persicum. Chem Nat Compn 1994;30:269-270.

Azizi M, Davareenejad G, Bos R, Woerdenbag HJ, Kayser O. Essential oil content and constituents of black zira Bunium persicum [Boiss.] B. Fedtsch.) from Iran during field cultivation (domestication). Essent Oil Res 2009;21:78-82.

Baser KHC, Ozek T, Abduganiev BE, Abdullaev UA, Aripov KN. Composition of the essential oil of Bunium persicum (Boiss.) B.Fedtsch. from Tajikistan. Essent Oil Res 1997;9:6-25.

Chizzola R, Saeidnejad AH, Azizi M, Oroojalian F, Mardani H. Bunium persicum: variability in essential oil and antioxidants activity of fruits from different Iranian wild populations. Genet Resour Crop Evol 2014;61:1621-1631.

Ehsani A, Hashemi M, Naghibi SS, Mohammadi Sh, Khalili-Sadaghiani S. Properties of Bunium Persicum essential oil and its application in Iranian white cheese against Listeria monocytogenes and Escherichia coli O157:H7. J Food Saf 2016;36:563-570.

Foroumadi A, Asadipour A, Arabpor F, Amanzadeh Y. Composition of the essential oil of Bunium persicum (Boiss.) B. Fedtsch. from Iran. Essent Oil Res 2002;14:161-162.

Haghirossadat F, Bernard F, Kalantar M, Sheikhha MH, Hokmollahi F, Azimzadeh M, Hoori M. Bunium Persicum (black caraway) of Yazd province: chemical assessment and evaluation of its antioxidant effects. J Shaheed Sadoughi Univ Med Sci 2010;18:284-291.

Jahansooz F, Sefidkon F, Najafi A, Ebrahimzadeh H, Najafi MS. Comparison of essential oils of Bunium persicum (Boiss) populations grown in Iran, Pakistan and India. Journal of Essential Oil Bearing Plants 2012;15:761-765.

Jalilzadeh-Amin Gh, Maham M, Dalir-Naghadeh B, Kheiri F. Effects of Bunium persicum (Boiss.) essential oil on the contractile responses of smooth muscle (an in vitro study). Vet Res Forum 2011;2:87-96.

Mazidi S, Rezaei K, Golmakani MT, Sharifan A, Rezazadeh Sh. Antioxidant Activity of Essential Oil from black zira (Bunium persicum Boiss.) Obtained by microwave-assisted hyrodistillation. Agri Sci Technol 2012;14:1013-1022.

Moghtader M, Mansori AI, Salari H, Farahmand A. Chemical composition and antimicrobial activity of the essential oil of Bunium persicum Boiss. seed. Iran J Med Aromatic Plants 2009;25:20-28.

Nickavar B, Adeli A, Nickavar A. Analyses of the essential oil from Bunium persicum fruit and its antioxidant constituents. J Oleo Sci 2014;63:741-746.

Oroojalian F, Kasra-Kermanshahi R, Azizi M, Bassami M. Phytochemical composition of the essential oils from three apiaceae species and their antibacterial effects on food-borne pathogens. Food Chem 2010;120:765-770.

Rabiey S, Hosseini H, Rezaei M. The hurdle effect of Bunium persicum essential oil, smoke and NaCl for controlling the Listeria monocytogenes growth in fish model systems. J Food Saf 2013;33:137-144.

Salehi P, Mohammadifand-Asghari B. Seed essential oil analysis of Bunium persicum by hydrodistillation- headspace solvent microextraction. Chem Nat Comp 2008;44:111-113.

Sanei-Dehkordi A, Vatandoost H, Abaei MR, Davari B, Sedaghat MM. Chemical composition and larvicidal activity of Bunium persicum essential oil against two important mosquitoes vectors. J Essential Oil-Bearing Plants 2016;19:349-357.

Shahsavari N, Baezegar M, Sahari M, Naghdibadi H. Antioxidant activity and chemical characterization of essential oil of Bunium persicum. Plant Foods Hum Nutr 2008;63:183-188.

Sharifi-far F, Yassa N, Mozaffarian V. Bioactivity of major components from the seeds of Bunium persicum (Boiss.) Fedtch. Pak J Pharm Sci 2010;23:300-304.

Tallei GR, Mosavi Z. Chemical composition and antibacterial activity of Buniom persicum from west of Iran. Asian J Chem 2009;21:4749-4754.

Chahota RK, Sharma V, Ghani M, Sharma TR, Rana JC, Sharma SK. Genetic and phytochemical diversity analysis in Bunium persicum populations of north-western Himalaya. Physiol Mol Biol Plants 2017;23:429-441.

Darvishi Zeidabadi D, Jalali Javaran M, Dehghani H, Rashidi Monfared S, Baghizadeh, A. An investigation of the HMGR gene and IPI gene expression in black caraway (Bunium persicum). Biotech 2018;8:405.

Rakhimov DA, Stepanenko GA, Ubaev Kh, Glushenkova AI, Kondratenko ES. Oil and carbohydrates of the fruit of Bunium persicum. Chem Nat Comp 1984;20:225-226.

Zangiabadi M, Sahari MA, Barzegar M, Naghdi-Badi H. Zataria multiflora and Bunium persicum essential oils as two natural antioxidants. J Med Plants 2012;11:8-12.

Nickavar B, Abolhasani FA. Screening of antioxidant properties of seven Umbelliferae fruits from Iran. Pak J Pharm Sci 2009;22:30-35.

Giancarlo S, Rosa LM, Nadjafi F, Francesco M. Hypoglycaemic activity of two spices extracts: Rhus coriaria L. and Bunium persicum Boiss. Nat Prod Res 2006;20:882-886.

Gholamhoseinian A, Razmi Z. Screening the methanolic extracts of some plants for tyrosinase inhibitory activity. Toxicol Env Chem 2012;94:310-318.

Namjoyan F, Jahangiri A, Azemi ME, Arkian E, Mousavi H. Inhibitory effects of Physalis alkekengi L., Alcea rosea L., Bunium persicum B. Fedtsch. and Marrubium vulgare L. on mushroom tyrosinase. Jundishapur J Nat Pharm Prod 2015;10:e23356.

Sharafati Chaleshtori F, Saholi M, Sharafati Chaleshtori R. Chemical Composition, Antioxidant and Antibacterial Activity of Bunium persicum, Eucalyptus globulus, and Rose Water on Multidrug-Resistant Listeria Species. J Evid Based Integr Med 2018;23: 2515690X17751314.

Aliakbarlu J, Sadaghiani SK, Mohammadi Sh. Comparative evaluation of antioxidant and anti-food-borne bacterial activities of essential oils from some spices commonly consumed in Iran. Food Sci Biotechnol 2013;22:1487-1493.

Menghani E, Pareek A, Negi RS, Ojha CK. Search for antimicrobial potentials from certain Indian medicinal plants. Res J Med Plants 2011;5:295-301.

Atapour M, Zahedi MJ, Mehrabani M, Safavi M, Keyvanfard V, Foroughi A, Siavoshi F, Foroumadi A. 2009. In vitro susceptibility of the gram-negative bacterium Helicobacter pylori to extracts of Iranian medicinal plants. Pharm Biol 2009;49:77-80.

Amber R, Adnan M, Tariq A, Khan SN, Mussarat S, Hashem A, Al-Huqail AA, Al-Arjani AF, Abd Allah EF. Antibacterial activity of selected medicinal plants of northwest Pakistan traditionally used against mastitis in livestock. Saudi J Biol Sci 2018;25:154-161.

Vatandoost H, Rustaie A, Talaeian Z, Abai M, Moradkhani F, Vazirian M, Hadjiakhoondi A, Shams-Ardekani MR, Khanavi M. Larvicidal Activity of Bunium persicum Essential Oil and Extract against Malaria Vector, Anopheles stephensi. J Arthropod Borne Dis 2018;12:85-93.

Mahmoudvand H, Tavakoli Oliaei R, Mirbadie SR, Kheirandish F, Tavakoli Kareshk A, Ezatpour B, Mahmoudvand H. Efficacy and Safety of Bunium Persicum (Boiss) to Inactivate Protoscoleces during Hydatid Cyst Operations. Surg Infect (Larchmt) 2016;17:713-719.

Zendehdel M, Torabi Z, Hassanpour S. Antinociceptive mechanisms of Bunium persicum essential oil in the mouse writhing test: role of opioidergic and histaminergic systems. Veterinarni Medicina 2015;60:63-70.

Mandegary A, Arab-Nozari M, Ramiar H, Sharifi-far F. Anticonvulsant activity of the essential oil and methanolic extract of Bunium persicum (Boiss). B. Fedtsch. J Ethnopharmacol 2012;140:447-451.

Khaksari M, Ahmadi M, Najafipour H, Shahrokhi N. 2014. Effect of Bunium persicum aqueous extract plus endurance exercise on cardiorespiratory capacity and serum lipid profile. Avicenna J Phytomed 2014;4:118-126.

Boskabady MH, Moghadas A. Inhibitory effect of Bunium persicum on histamine (H1) receptors of guinea pig tracheal chains. Phytomedicine 2004;11:411-415.

Jalilzadeh-Amin G, Nabizadeh H, Maham M. Inhibitory effect of Bunium persicum Boiss essential oil on castor-oil induced diarrhea. J Kerman Univ Med Sci 2014;21:139-150.

Jalilzadeh-Amin G, Yousefi AR, Abdollahi-Pirbazari M. Anti ulcerogenic activity of Bunium percicum Boiss. essential oil in induced ulcer models in Wistar rats. J Gorgan Univ Med Sci 2014;16:37-44.

Ali T, Saeed K, Abdullah M, Murtaza I. Antihematotoxic role of Bunium persicum seed differential extracts in animal model: reactive oxygen species might be a contributor. Osong Public Health and Res Perspect 2014;5:358-363.

Mehni S, Zahrani ST, Taheri-Sarvtin M, Mojab F, Mirzaei M, Vazirnasab H. Therapeutic effects of Bunium persicum Boiss (black zira) on Candida albicans vaginitis. Biomedical Pharmacol 2015;8:1103-1109.

Nazari M, Taghizadeh A, Bazzaz MM, Rakhshandeh H, Shokri S. Effect of Persian Medicine Remedy on Chemotherapy Induced Nausea and Vomiting in Breast Cancer: A Double Blind, Randomized, Crossover Clinical Trial. Electron Physician 2017;9:3535-3543.

Aghili MH. In: Rahimi R, Shams-Ardekani MR, Farjadmand F. eds. Makhzan-al-advia. Tehran University of Medical Sciences. Tehran 2009; p 702.

Tonkaboni MM. In: Rahimi R, Shams-ardekani MR, Farjadmand F. eds. Tohfeh-al-Momenin. Shahid Beheshti University of Medical Sciences. Tehran 2007; p 723.

Seri A, Khorsand M, Rezaei Z, Hamedi A, Takhshid MA. Inhibitory Effect of Bunium Persicum Hydroalcoholic Extract on Glucose-Induced Albumin Glycation, Oxidation, and Aggregation In Vitro. Iran J Med Sci 2017;42:369-376.

Dutt B, Nath D, Chauhan NS, Sharma KR, Sharma SS. Ethno-medicinal plant resources of tribal Pangi valley in district Chamba, Himachal pradesh, India. Int J Bio-resource Stress Managb 2014;5:416-421.

Lone PA, Bhardwaj AK, Bahar FA. A study of some locally available herbal medicines for the treatment of various ailments in Bandipora district of J&K, India. Int J Pharm Bio Sci 2013;4:440-453.

Pandey A, Mavinkurve RG, Garg JK. Revitalizing traditional health care practices by exploring medicinal plants: a case study of Jorhat, Assam, India. Bull Env Pharmacol Life Sci 2013;3:158-164.

Phani-Kumar G, Gupta S, Murugan P, Bala-Singh Sh. Ethnobotanical studies of Nubra valley - a cold arid zone of Himalaya. Ethnobot Leaflets 2009;13:752-765.

Singh-Chauhan N. Medicinal and aromatic plants of Himachel. Indus publishing company, New Delhi 1999; p 132.

Ahmad M, Sultana Sh, Fazl-i-hadi S, Hadda T, Rashid S, Zafar M, Khan MA, Khan MPZ, Yaseen G. An ethnobotanical study of medicinal plants in high mountainous region of Chail valley (district Swat- Pakistan). J Ethnobiol Ethnomed 2014;10:36.

Ali H, Qaiser M. The ethnobotany of Chitral valley, Pakistan with particular reference to medicinal plants. Pak J Bot 2009;41:2009-2041.

Shah SA, Shah NA, Ullah S, Alam MM, Badshah H, Ullah S, Mumtaz AS. Documenting the indigenous knowledge on medicinal flora from communities residing near Swat river (Suvastu) and in high mountainous areas in Swat-Pakistan. J Ethnopharmacol 2016;182:67-76.

Sher H, Bussmann RW, Hart R, de-Boer HJ. Traditional use of medicinal plants among Kalasha, Ismaeli and Sunni groups in Chitral district, Khyber Pakhtunkhwa province. J Ethnopharmacol 2016;188:57-69.

Khojimatov OK, Abdiniyazova GJ, Pak VV. Some wild growing plants in traditional foods of Uzbekistan. J Ethnic Foods 2015;2:25-28.

Rakhimov DA, Yuldasheva NP, Ubaev Kh, Khamidkhodzhaev SA. Polysaccharides of Bunium persicum. Chem Nat Comp 1987;23:116-117.

Ahangarpour A, Oroojan AA, Heydari H, Ahmadi I. Effects of aqueous and hydro-alcoholic extracts of Bunium persicum seed on insulin secretion from male mouse-isolated langerhans islets. J Urmia Univ Med Sci 2014;25:742-751.

Gholamhoseinian A, Moradi MN, Sharifi-far F. Screening the methanol extracts of some Iranian plants for acetylcholinesterase inhibitory activity. Res Pharm Sci 2009;4:105-112.

Gholamhoseinian A, Shahouzehi B, Sharifi-far F. Inhibitory activity of some plant methanol extracts on 3-hydroxy-3-methylglutaryl coenzyme a reductase. Int J Pharmacol 2010;6:705-711.

Gholamhoseinian A, Shahouzebi B, Sharifi-far F. Inhibitory effect of some plant extracts on pancreatic lipase. Int J Pharmacol 2010;6:18-24.

Gholamhoseinian A, Fallah H, Sharifi-far F, Mirtajaddini M. Alpha mannosidase inhibitory effect of some Iranian plant extracts. Int J Pharmacol 2008;4:450-455.

Files
IssueVol 5, No 3, 2020 QRcode
SectionReview Article(s)
DOI https://doi.org/10.18502/tim.v5i3.4322
Keywords
Bunium persicum Carum persicum Zireh Kermani Traditional medicine Pharmacology Phytochemistry

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
1.
Majidi Z, Bina F, Kahkeshani N, Rahimi R. Bunium persicum: A Review of Ethnopharmacology, Phytochemistry, and Biological Activities. Trad Integr Med. 2020;5(3):150-176.