Potential Herbal Medicines Bioactive Compounds Against Hepatocellular Carcinoma: A Review of Computational Bioinformatics Studies
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Abdolmajid Ghasemian
,
Abdolbaset Mazarzaei
,
Hussein T. Abdulabbas
,
Mahsa Rostami Chijan
,
Mojtaba Memariani
,
Farnaz Karami
,
Ensieh Nournia
,
Elham Zarenezhad
Abstract
Hepatocellular Carcinoma (HCC) is a leading cause of death from cancer worldwide. Herbal medicines have numerous benefits such as affordability, low side effects and low cytotoxicity. Bioinformatics tools or so called computer-aided drug design (CADD) have deciphered extraordinary capability in rapid and cost-effective exploration or prediction of potential alternatives such as HMs bioactive compounds. Bioactive compounds such as stigmasta-5,22-dien-3-one (targeting PIK3R1, SRC), lupeol, isomeldenin, nimocinol, gedunin and nimbidinin (targeting Akt), luteolin (targeting EGFR) have inferred potential anti-HCC effects according to computational bioinformatics studies. Considering high anti-HCC potential of these bioactive compounds, their formulation or combinatory application is promising for efficient cancer therapy.
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| Issue | Vol. 11, No. 3, 2026 -In Press- | |
| Section | Review Article(s) | |
| Keywords | ||
| Hepatocellular carcinoma Herbal medicines Bioactive compounds Computational studies | ||
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