Review Article

Herbal Therapies in Cataract Treatment: A Review of Current Research in Public Health Perspective

Abstract

Cataract is a condition of visual impairment caused by clouding of crystalline lens. Cataract exhibits a significant prevalence across diverse age demographics; however, primarily it is causing substantial welfare concerns in the aging population. Presently available interventions are largely restricted to surgical options, highlighting the need of alternative treatments. This review aims to understand the importance of utilizing traditional herbal therapies beyond conventional treatment. A comprehensive literature review was conducted using a variety of databases, including ScienceDirect, PubMed, Scopus, Embase, Publons, Europe PMC, Google Scholar and Clinical Trials Registry of India (CTRI) to gather relevant information regarding existing and prospective plant-based treatment alternatives for cataract. The exhaustive review has covered nature of incidence, etiology, development of cataract, commercially available allopathic eye drops and Plant-based  formulations for management of cataract. The plant-based clinical studies registered in CTRI database and online published literature were examined. The observations reflected that herbal therapies are increasingly being explored and scientific validations were undertaken towards identifying herbal medicines in management of cataract. The findings emphasize that anticataract mechanisms of plant-based medications are primarily attributed to their antioxidant and free radical scavenging properties. Currently available therapies are protecting lens transparency and are directed towards arresting the progression of cataract from immature to mature and hyper mature stages. 

Nam SW, Lim DH, Cho KY, Kim HS, Kim K, et al. Risk factors of presenile nuclear cataract in health screening study. BMC Ophthalmol 2018;18:1-9.

Andjelic S, Drašlar K, Hvala A, Hawlina M. Structural characteristics of the lens in presenile cataract. Front Med 2021;8.

Das GK, Chhabra P, Sahu P, Kumar S, Kumar N. Presenile cataract and its risk factors: A case control study. J Family Med Prim Care 2019;8:2120-2123.

World Health Organization. Blindness and vision impairment. World Health Organization. Published August 10, 2023. https://www.who.int/news-room/fact-sheets/detail/blindness-and-visual-impairment. (Accessed: 13 February, 2025)

Parkosadze K, Kalmakhelidze T, Tolmacheva M, Chichua G, Kezeli A, et al. Persistent biases in subjective image focus following cataract surgery. Vis Res 2013;89:10-17.

Nithya M, Manivannan R, Joy J, Saritha B, Raja S, et al. A review on medicinal plants used in the treatment of cataract. Int J Pharm Sci Rev Res 2023;78.

Joshi N, Shukla, GS, Kumar P. Pharmaceutical preparation and stability study of Netramritam a herbal eye drop for Cataract. J Ayurveda Integr Med 2023;8:26-29.

Steinmetz JD, Bourne RR, Briant PS, Flaxman SR, Taylor HR, et al. Causes of blindness and vision impairment in 2020 and trends over 30 years, and prevalence of avoidable blindness in relation to VISION 2020: the right to sight: an analysis for the global burden of disease study. Lancet Glob Health 2021;9:e144-e160. doi:10.1016/s2214-109x(20)30489-7

Mencucci R, Stefanini S, Favuzza E, Cennamo M, De Vitto C, et al. Beyond vision:Cataract and health status in old age, a narrative review. Front Med 2023;10.

Hashemi H, Pakzad R, Yekta A, Aghamirsalim M, Pakbin M, et al. Global and regional prevalence of age-related cataract: a comprehensive systematic review and meta-analysis. Eye 2020;34.

Fang R, Yu YF, Li EJ, Lv NX, Liu ZC, et al. Global, regional, national burden and gender disparity of cataract: findings from the global burden of disease study 2019. BMC Public Health 2022;22.

Schlenker MB, Thiruchelvam D, Redelmeier DA. Association of cataract surgery with traffic crashes. JAMA Ophthalmol 2018;136:998.

Meuleners LB, Brameld K, Fraser ML, Chow K. The impact of first- and second-eye cataract surgery on motor vehicle crashes and associated costs. Age and Ageing 2018;48:128-133.

Sheeladevi S, Lawrenson JG, Fielder AR, Suttle CM. Global prevalence of childhood cataract: a systematic review. Eye 2016;30:1160-1169.

Wishart TFL, Flokis M, Shu DY, Das SJ, Lovicu FJ. Hallmarks of lens aging and cataractogenesis. Exp Eye Res 2021;210:108709.

Sheppard WEA, McCarrick D, Wilkie RM, Baraas RC, Coats RO. A systematic review of the effects of second-eye cataract surgery on motor function. Front Aging 2022;3.

Berry V, Georgiou M, Fujinami K, Quinlan R, Moore A, et al. Inherited cataracts: molecular genetics, clinical features, disease mechanisms and novel therapeutic approaches. Br J Ophthalmol 2020;104:1331-1337.

Heruye SH, Maffofou Nkenyi LN, Singh NU, Yalzadeh D, Ngele KK, et al. Current trends in the pharmacotherapy of cataracts. Pharmaceuticals 2020;13:15.

Xu J, Fu Q, Chen X, Yao K. Advances in pharmacotherapy of cataracts. Ann Transl Med 2020;8:1552-1552.

Webber KJ, Fylan F, Wood JM, Elliott DB. Experiences following cataract surgery – patient perspectives. Ophthalmic Physiol Opt 2020;40:540-548.

Palagyi A, Morlet N, McCluskey P, White A, Meuleners L, et al. Visual and refractive associations with falls after first-eye cataract surgery. J Cataract Refract Surg 2017;43:1313-1321.

Desapriya E, Subzwari S, Scime-Beltrano G, Samayawardhena LA, Pike I. Vision improvement and reduction in falls after expedited cataract surgery. J Cataract Refract Surg 2010;36:13-19.

Supuk E, Alderson A, Davey CJ, Green C, Litvin N, et al. Dizziness, but not falls rate, improves after routine cataract surgery: the role of refractive and spectacle changes. Ophthalmic Physiol Opt 2015;36:183-190.

Babizhayev MA. Generation of reactive oxygen species in the anterior eye segment. Synergistic codrugs of N-acetylcarnosine lubricant eye drops and mitochondria-targeted antioxidant act as a powerful therapeutic platform for the treatment of cataracts and primary open-angle glaucoma. BBA Clin 2016;6:49-68.

Whitson JA, Wilmarth PA, Klimek J, Monnier VM, David L, et al. Proteomic analysis of the glutathione-deficient LEGSKO mouse lens reveals activation of EMT signaling, loss of lens specific markers, and changes in stress response proteins. Free Rad Bio Med 2017;113:84-96.

Hu CC, Liao JH, Hsu KY, Lin IL, Tsai MH, et al. Molecular Vision: Role of pirenoxine in the effects of catalin on in vitro ultraviolet-induced lens protein turbidity and selenite-induced cataractogenesis in vivo. Mol Vis 2011;17:1862.

Kociecki J, Załecki K, Wasiewicz-Rager J, Pecold K. Evaluation of effectiveness of Catalin eyedrops in patients with presenile and senile cataract. Klin Oczna 2004;106:778-782.

Chasovnikova LV, Formazyuk VE, Sergienko VI, Boldyrev AA, Severin SE. The antioxidative properties of carnosine and other drugs. Biochem Int 1990;20:1097-1103

Stankiewicz A, Poppe E, Stasiewicz B, Gołebiowska-Hrycukowa A. Evaluation of the effectiveness of Quinax in the prevention of the development of senile cataract. Klin Oczna 1990;92:52-54.

Belenichev IF, Kucherenko LI, Mazur IA, Akopyan RR, Portnaya EA. Experimental assessment of the specific activity of a new dosage form of angiolin in cataract modeling. Biol Markers Guided Ther 2019;6:113-120.

Ivanova AV, Gerasimova EL, Gazizullina ER, Okulova YA, Matern AI, et al. Antioxidant and antiradical activity of drugs intended for treating ophthalmic disorders. Pharm Chem J 2018;52:694-699.

Petrov SY, Kozlova IV, Poleva RP. Conservative treatment for cataract: state-of-the-art. Clin Ophthalmol 2019;19:206-210.

Sevin G, Kerry Z, Sozer N, Ozsarlak-Sozer G. Taurine supplementation protects lens against glutathione depletion. Eur Rev Med Pharmacol Sci 2021;25:4520-4526.

Winkler R. Iodine—A potential antioxidant and the role of Iodine/Iodide in health and disease. Nat Sci 2015;07:548-557.

Shen H, Gou S, Shen J, Zhu Y, Zhang Y, et al. Synthesis and biological evaluations of novel bendazac lysine analogues as potent anticataract agents. Bioorg Med Chem Lett 2010;20:2115-2118.

Ji L, Cheng L, Yang Z. Diosgenin, a novel aldose reductase inhibitor, attenuates the galactosemic cataract in rats. J Diabetes Res 2017;2017:1-9.

Toh T, Morton J, Coxon J, Elder MJ. Medical treatment of cataract. Clin Exp Ophthalmol 2007;35:664-671.

Ho MC, Peng YJ, Chen SJ, Chiou SH. Senile cataracts and oxidative stress. Clin Gerontol Geriatr 2010;1:17-21.

Makley LN, McMenimen KA, DeVree BT, Goldman JW, McGlasson BN, et al. Pharmacological chaperone for α-crystallin partially restores transparency in cataract models. Science 2015;350:674-677.

Zhao L, Chen XJ, Zhu J, Xi YB, Yang X, et al. Lanosterol reverses protein aggregation in cataracts. Nature 2015;523:607-611.

Saberwal G. How to make Clinical Trials Registry-India world class. Curr Sci 2023;124:785.

Tharyan P. Prospective registration of clinical trials in india: strategies, achievements & challenges. J Evid -Based Med 2009;2:19-28.

Usuki Y, Usuki S, Hommura S. Successful treatment of a senile diabetic woman with cataract with goshajinkigan. Am J Chin Med 1991;19:259-263.

Zeng FL, Gu Z, Zhang XY, Li SY, Liu XS. Clinical study on early senile cataract treated by Shezhu Mingmu powder. Chin J Integr Tradit West Med 1997;3:186-190.

Song Y, Chen W, Fu K, Wang Z. The application of pearls in traditional medicine of China and their chemical constituents, pharmacology, toxicology, and clinical research. Front Pharmacol 2022;13.

Yan Z, Zong Y, Zhang C, Han Z, Wu L, et al. Exploring the role of Tibetan medicinal formula Qishiwei Zhenzhu Pills (Ranasampel) against diabetes mellitus-linked cognitive impairment of db/db mice through serum pharmacochemistry and microarray data analysis. Front Aging Neurosci 2022;14.

Woo GC, Halpern GM, Kwong EY. Effect of TCM-derived extracts on cataract development in the elderly: a pilot study. Prog Nutr 2009;11:12-17.

Horng CT, Ma JW, Shieh PC. Improvement of presbyopia using a mixture of traditional chinese herbal medicines, including cassiae semen, wolfberry, and dendrobium huoshanense. Evid Based Complement Alternat Med 2021;2021:1-13.

Imelda E, Idroes R, Khairan K, Lubis RR, Abas AH, et al. Natural antioxidant activities of plants in preventing cataractogenesis. Antioxidants 2022;11:1285.

Suryanarayana P, Kumar PA, Saraswat M, Petrash JM, Reddy GB. Inhibition of aldose reductase by tannoid principles of Emblica officinalis: implications for the prevention of sugar cataract. Mol Vis 2004;10:148-154.

Suryanarayana P, Saraswat M, Petrash JM, Reddy GB. Emblica officinalis and its enriched tannoids delay streptozotocin-induced diabetic cataract in rats. Mol Vis 2007;13:1291-1297.

Lee YK, Hong EY, Whang WK. Inhibitory effect of chemical constituents isolated from artemisia iwayomogi on polyol pathway and simultaneous quantification of major bioactive compounds. Biomed Res Int 2017;2017:1-12.

Wang Z, Hwang SH, Lim SS. Characterization of DHDP, a novel aldose reductase inhibitor isolated from Lysimachia christinae. J Funct Foods 2017;37:241-248.

Yoo NH, Jang DS, Lee YM, Jeong IH, Cho JH, et al. Anthraquinones from the Roots of Knoxia valerianoides inhibit the formation of advanced glycation end products and rat lens aldose reductase in vitro. Arch Pharm Res 2010;33:209-214.

Zheng HH, Luo CT, Chen H, Lin JN, Ye CL, et al. Xanthones from Swertia mussotii as Multitarget‐Directed Antidiabetic Agents. ChemMedChem 2014;9:1374-1377.

Kim YS, Kim NH, Jung DH, Jang DS, Lee YM, et al. Genistein inhibits aldose reductase activity and high glucose-induced TGF-β2 expression in human lens epithelial cells. Eur J Pharmacol 2008;594:18-25.

Ou Y, Yuan Z, Li K, Yang X. Phycocyanin may suppress d-galactose-induced human lens epithelial cell apoptosis through mitochondrial and unfolded protein response pathways. Toxicol Lett 2012;215:25-30.

Kim NH, Kim YS, Lee YM, Jang DS, Kim JS. Inhibition of aldose reductase and xylose-induced lens opacity by puerariafuran from the roots of pueraria lobata. Biol Pharm Bull 2010;33:1605-1609.

Thiagarajan R, Manikandan R. Antioxidants and cataract. Free Radic Res 2013;47:337-345.

Jeevanandam J, Madhumitha R, Saraswathi NT. Identification of potential phytochemical lead against diabetic cataract: An insilico approach. Mol Struct 2020;1226:129428.

Castro-Castaneda CR, Altamirano-Lamarque F, Ortega-Macías AG, Santa Cruz-Pavlovich FJ, Gonzalez-De la Rosa A, et al. Nutraceuticals: a promising therapeutic approach in ophthalmology. Nutrients 2022;14:5014.

Ikonne EU, Ikpeazu VO, Ugbogu EA. The potential health benefits of dietary natural plant products in age-related eye diseases. Heliyon 2020;6:e04408.

Ertekin MV, Koçer İ, Karslıoğlu İ, Taysi S, Gepdiremen A, et al. Effects of Oral Ginkgo biloba Supplementation on Cataract formation and oxidative stress occurring in lenses of rats exposed to total cranium radiotherapy. Jpn J Ophthalmol 2004;48:499-502.

Halder N, Joshi S, Gupta SK. Lens aldose reductase inhibiting potential of some indigenous plants. J Ethnopharmacol 2003;86:113-116.

Al Rashid MH, Kundu A, Mandal V, Wangchuk P, Mandal SC. Preclinical and clinical trials of Indian medicinal plants in disease control. In: Herbal Medicine in India: Indigenous Knowledge, Practice, Innovation and its Value, Ed, Sen S, Raja C, Springer Nature Singapore Pte Ltd 2020; pp 119-142.

Rooban BN, Sasikala V, Devi VG, Sahasranamam V, Abraham A. Prevention of selenite induced oxidative stress and cataractogenesis by luteolin isolated from Vitex negundo. Chem Biol Interact 2012;196:30-38.

Rooban BN, Sasikala V, Sahasranamam V, Abraham A. Vitex negundo modulates selenite-induced opacification and cataractogensis in rat pups. Biol Trace Elem Res 2010;138:282-292.

Anitha TS, Muralidharan AR, Annadurai T, Jesudasan CA, Thomas PA, et al. Putative free radical-scavenging activity of an extract of Cineraria maritima in preventing selenite-induced cataractogenesis in Wistar rat pups. Mol Vis 2013:19:2551-2560.

Lian RR, Afshari NA. The quest for homeopathic and nonsurgical cataract treatment. Curr Opin Ophthalmol 2020;31:61-66.

Hu N, Jin FY, Gao MM, Liu LJ, Wang JH, et al. Baicalein improves Na2SeO3 induced cataract by enhancing the antioxidant capacity of juvenile Sprague Dawley Rat. J Ethnopharmacol 2024;320:117433.

Jadhav N, Auti SA. Brief compilation on triphala–a wonder compound in ayurvedic ophthalmology. Ayurpharm Int J Ayur Alli Sci 2018;7:123-128.

Biswas NR, Gupta SK, Das GK, Kumar N, Mongre PK, et al. Evaluation of Ophthacare® eye drops—a herbal formulation in the management of various ophthalmic disorders. Phytother Res 2001;15:618-620.

Rák T, Csutak A. Complementary practices in pharmacy and their relation to glaucoma - classification, definitions, and limitations. Sci Pharm 2024;14:16.

IssueVol 11, No 1, 2026 -In Press- QRcode
SectionReview Article(s)
Keywords
Antioxidant Cataract Clinical trial CTRI Herbal medicine

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How to Cite
1.
Ramkumar S, Nogia P, R R, M R, R K R. Herbal Therapies in Cataract Treatment: A Review of Current Research in Public Health Perspective. Trad Integr Med. 2026;11(1).