Novel Thermal-Therapy Protocol (SINA1.2) from Traditional Persian Medicine (TPM): A Pilot on Diabetic Rats

  • Zahra Sarbaz Hoseini School of Traditional Persian Medicine, Qom University of Medical Sciences, Qom, Iran
  • Majid Asghari School of Traditional Persian Medicine, Qom University of Medical Sciences, Qom, Iran
  • Hamid Heidari School of Medicine, Qom University of Medical Sciences, Qom, Iran
  • Abolfazl Mohammadbeigi Department of Epidemiology and Biostatistics, School of Health, Qom University of Medical Sciences, Qom, Iran
  • Mahdi Alizadeh Vaghasloo Department of Traditional Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran
Diabetes; Insulin resistance; Persian medicine; Thermal-therapy; SINA therapy


One of guilty pathologies in insulin resistance and type 2 diabetes mellitus (T2DM) is ectopic fat accumulation in organs like pancreas, liver and skeletal muscles due to fatty acid’s bad digestion. This situation corresponds much with a spectrum of illnesses named the Soo ul Qinya & Estesgha in Traditional Persian Medicine (TPM). We renamed and redefined the concept as “The Bad-Anbaasht Syndrome” meaning bad-deposition. One of its basic treatments mentioned is thermal-therapy which interestingly also shown to benefit T2DM in recent studies. We designed a novel protocol named SINA therapy to treat T2DM including sauna’s benefits but reducing its side effects and then performed an animal pilot study. Five Wistar rats made diabetic by high fat diet and low dose streptozotocin, were treated daily by month long SINA 1.2 treatment protocol (1 cc Oxymel gavage and then 30 min thermal therapy in 37 ̊C dry sauna incubator). Weight and blood glucose were measured at beginning and at the end. Although Mean weights increased significantly from 296 to 321 (paired T test, p = 0.022) but surprisingly the mean blood glucose lowered significantly from 200mg/dl to 127mg/dl (p = 0.049). According to results of this pilot study, SINA therapy 1.2 is probable to have benefits in treatment of T2DM, but yet needs further experimental and clinical evidence.


Cho NH, Shaw JE, Karuranga S, Huang Y, da Rocha Fernandes JD, Ohlrogge AW, Malanda B. IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045. Diabetes Res Clin Pract 2018;138:271-281.

Global report on diabetes World Health Organization Geneva, 2016.

Mathers CD, Loncar D. Projections of global mortality and burden of disease from 2002 to 2030. Plos med 2006;3:e442.

World Health Organization-Diabetes, country profiles 2016. Available from:

Borén J, Taskinen MR, Olofsson SO, Levin M. Ectopic lipid storage and insulin resistance: a harmful relationship. J Intern Med 2013;274:25-40.

Gustafson B, Hedjazifar S, Gogg S, Hammarstedt A, Smith U. Insulin resistance and impaired adipogenesis. Trends Endocrinol Metab 2015;26:193-200

Samuel VT, Shulman GI. The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux. J Clin Invest 2016;126:12.

Ertunc ME, Hotamisligil GS. Lipid signaling and lipotoxicity in metabolic inflammation: indications for metabolic disease pathogenesis and treatment. J Lipid Res 2016:jlr.R066514.

Lim S, Meigs JB. Links between ectopic fat and vascular disease in humans. Arterioscler Thromb Vasc Biol 2014;34:1820-1826.

Rosen ED, Spiegelman BM. What we talk about when we talk about fat. Cell 2014;156:20-44.

Goldberg IJ, Trent CM, Schulze PC. Lipid metabolism and toxicity in the heart. Cell Metab 2012;15:805-812.

Han TS, Lean MEJ. A clinical perspective of obesity, metabolic syndrome and cardiovascular disease. JRSM Cardiovasc Dis 2016;5:2048004016633371.

Ruiz-Núñez B, Dijck-Brouwer DJ, Muskiet FA. The relation of saturated fatty acids with low-grade inflammation and cardiovascular disease. J Nutr Biochem 2016;36:1-20.

Byrne CD, Targher G. Ectopic Fat, Insulin Resistance, and Nonalcoholic Fatty Liver Disease. Implications for Cardiovascular Disease 2014;34:1155-1161.

Lyons C, Kennedy E, Roche H. Metabolic Inflammation-Differential Modulation by Dietary Constituents. Nutrients 2016;8:247.

Samuel VT, Shulman GI. Mechanisms for insulin resistance: common threads and missing links. Cell 2012;148:852-871.

Organization WH. WHO traditional medicine strategy 2014–2023. 2013. Geneva: World Health Organization. 2015.

Heravi M. Bahr al-Jawaher. Jalaluddin Publications. Qom 2008; p 22. [in Arabic]

Kermani N. Sharh al-Asbab va al-Alamat. Vol 1. Jalaleddin. Qom 2008; p 34.‏ [in Arabic]

Pourhosseini M, Nojavan F, Mohammadbeigi A, Moradi H. Misinterpret of a unique clinical presentation named "Soo ul qinya" in Traditional Persian medicine with "Anemia". IJAM 2019; 10:130-135.

Emtiazy M, Keshavarz M, Khodadoost M, Kamalinejad M, Gooshahgir SA, Shahrad Bajestani H, Relation between body humors and hypercholesterolemia: An Iranian traditional medicine perspective based on the teaching of Avicenna. Iran Red Crescent Med J 2012;14:133-8.

Alizadeh Vaghasloo M, Zareian MA, Soroushzadeh SMA. The Concept of Nozj. Trad Integr Med 2016;1:133-135.

Alizadeh Vaghasloo M, Naghizadeh A. The Concept of the Haar-re-Gharizi and Hararate Gharizi: The Innate Hot [Substance] and Heat. Trad Integr Med 2017;2:3-8.

Jorjani L. Zakhireh kharazmshahi. Bonyade Farhang Ira. Tehean 1992; p 653.

Ibn Sina A. al-Qanun fi al-tibb. Alamy Le-Al-Matbooat institute. Lebanon 2005; pp 125-127.

Alizadeh Vaghasloo M, Naghizadeh A, Keshavarz M. The Concept of Pulse. Trad Integr Med 2017;2:54-60.

Moradi F, Alizadeh F, Naghizadeh A, Karimi M, Alizadeh Vaghasloo M. The Concept of “Masam” (Pores) in of Persian Medicine. Trad Integr Med 2017;2:160-165.

Shirbeigi L, Zarei A, Naghizadeh A, Alizadeh Vaghasloo M. The Concept of Temperaments in Traditional Persian Medicine. Trad Integr Med 2017;2:143-156.

Nazem Jahan MA. Exireh Azam. Vol 3. Iran University of Medical Sciences & Health Services Research Institute for Islamic and Complementary Medicine (RICM). Tehran 2008; p 66. [In Persian]

Geiger PC, Gupte AA. Heat shock proteins are important mediators of skeletal muscle insulin sensitivity. Exerc Sport Sci Rev 2011;39:34.

Henstridge DC, Whitham M, Febbraio MA. Chaperoning to the metabolic party: the emerging therapeutic role of heat-shock proteins in obesity and type 2 diabetes. Mol Metab 2014;3:781-793.

Krause M, Ludwig MS, Heck TG, Takahashi HK. Heat shock proteins and heat therapy for type 2 diabetes: pros and cons. Curr Opin Clin Nutr Metab Care 2015;18:374-380.

McCarty MF, Barroso-Aranda J, Contreras F. Regular thermal therapy may promote insulin sensitivity while boosting expression of endothelial nitric oxide synthase–effects comparable to those of exercise training. Med Hypotheses 2009;73:103-105.

Beever R. The effects of repeated thermal therapy on quality of life in patients with type II diabetes mellitus. J Altern Complement Med 2010;16:677-681.

Bathaie SZ, Jafarnejad A, Hosseinkhani S, Nakhjavani M. The effect of hot-tub therapy on serum Hsp70 level and its benefit on diabetic rats: a preliminary report. Int J Hyperth 2010;26:577-585.

Hooper PL, Balogh G, Rivas E, Kavanagh K, Vigh L. The importance of the cellular stress response in the pathogenesis and treatment of type 2 diabetes. Cell Stress Chaperon. 2014;19:447-464.

Hayden MR, Sowers KM, Pulakat L, Joginpally T, Krueger B, Whaley-Connell A. Possible mechanisms of local tissue renin-angiotensin system activation in the cardiorenal metabolic syndrome and type 2 diabetes mellitus. Cardiorenal Med 2011;1:193-210.

Karpe PA, Tikoo K. Heat Shock Prevents Insulin Resistance–Induced Vascular Complications by Augmenting Angiotensin-(1-7) Signaling. Diabetes 2014;63:1124-1139.

Rosas PC, Nagaraja GM, Kaur P, Panossian A, Wickman G, Garcia LR. Hsp72 (HSPA1A) prevents human islet amyloid polypeptide aggregation and toxicity: a new approach for type 2 diabetes treatment. PloS one 2016;11:e0149409

Walter J, Crinnion ND. Sauna as a valuable clinical tool for cardiovascular, autoimmune, toxicant-induced and other chronic health problems. Altern Med Rev 2011;16:215:225.

Zargaran A, Zarshenas MM, Mehdizadeh A, Mohagheghzadeh A. Oxymel in medieval Persia. Pharm Hist (Lond). 2012;42:11-13.

Derakhshandeh-Rishehri, SM. Effect of honey vinegar syrup on blood sugar and lipid profile in healthy subjects. IJPM 2014;5:1608.‏

Ibn Nafis. Al-mojez fi-teb. Dar-ol-mahajat-ol-baizaa. Beirut 1986; p 22. [in Arabic]

Montagna W. Cutaneous comparative biology. Arch Dermatol 1971;104:pp 577-579.

Skovsø S. Modeling type 2 diabetes in rats using high fat diet and streptozotocin, J Diabetes Invest 2014;5:349-358.

How to Cite
Sarbaz Hoseini Z, Asghari M, Heidari H, Mohammadbeigi A, Alizadeh Vaghasloo M. Novel Thermal-Therapy Protocol (SINA1.2) from Traditional Persian Medicine (TPM): A Pilot on Diabetic Rats. Trad Integr Med. 4(3):102-108.
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