Effect of Bastibaj, a Traditional Persian Formula, on Premature Ejaculation: Observation of a Traditional Treatment

  • Mohammad Mahdi Ahmadian-Attari Evidence-Based Phytotherapy and Complementary Medicine Research Center, Alborz University of Medical Sciences, Karaj, Iran
  • Seyed Hamed Moosavi-Asil Department of Persian Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran
  • Leila Mohammad Taghizadeh Kashani Department of Traditional Medicine, Medicinal Plants Research Center of Barij, Kashan, Iran
  • Meysam Shirzad Department of Persian Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran
Premature ejaculation; Traditional persian medicine; Herbal medicine; Bastibaj


Premature ejaculation (PE) is one of the main sexual problems among the male population. There is a folk treatment for this ailment in a small town near Kashan, Iran. The treatment contains hydro-alcoholic extracts of Tribulus terrestris L., Rosa × damascena Herrm, Zingiber officinale Roscoe, and Crocus sativus L. in honey. The aim of this preliminary study was to evaluate the effect of the syrup on premature ejaculation. The study population was 17 outpatients visited by a traditional healer. Each patient was diagnosed clinically based on the Premature Ejaculation Diagnostic Tool (PEDT). Inclusion criteria included male participants between 20 to 60 years old, PE more than 6 months, PEDT score more than 11, IELT more than 1 minute, no severe organic disease. Exclusion criteria included taking any chemical drug during the intervention, and sexual contacts less than twice in 3 weeks. 17 male patients aged between 26-65 years old were eligible for the study according to the inclusion criteria. The patients enrolled in the study, filled out the written consent form and conditions of the research were explained. The medication (Bastibaj syrup) was administered for the patients 5 milliliters 3 times daily for 3 sequential weeks. The intravaginal ejaculatory latency time was recorded in all coitus. After the course of the intervention, the mean of IELTs before and after the intervention was compared via paired T-test. Results show that the mean IELT before the intervention (33.2 seconds) in comparison to after it (129.3 seconds) has been improved significantly (P<0.01). According to the results, the study revealed that the traditional remedy prescribed in this study, i.e. Bastibaj, can be effective in patients with premature ejaculation, and can prolong the IELT significantly


Vukina J, McBride JA, Carson CC, Coward RM. Premature ejaculation. Evidence‐Based Urology. 2018 Aug 7:569-78.

Hartmut Porst a, Francesco Montorsi, Raymond C. Rosen, Lisa Gaynor,Stephanie Grupe, Joseph Alexander. The Premature Ejaculation Prevalence and Attitudes (PEPA) Survey: Prevalence, Comorbidities, and Professional Help-Seeking .european urology 51 (2007) 816–824

Raymond C. Rosen and Stanley Althof. Impact of Premature Ejaculation: The Psychological, Quality of Life, and Sexual Relationship Consequences. J Sex Med 2008;5:1296–1307

Franc¸ois Giuliano, Donald L. Patrick, Hartmut Porst, Giuseppe La Pera,Andrzej Kokoszka, Sanjay Merchant, Margaret Rothman, Dennis. Gagnon,Elena Polverejan. Premature Ejaculation: Results from a Five-Country European Observational Study. european urology 53 ( 2 0 0 8 ) 1048–1057

Castiglione F, Albersen M, Hedlund P, Gratzke C, Salonia A, Giuliano F. Current pharmacological management of premature ejaculation: a systematic review and meta-analysis. European urology. 2016 May 1;69(5):904-16.

IA Abdel-Hamid, EA El Naggar and A-H El Gilany. Assessment of as needed use of pharmacotherapy and the pause-squeeze technique in premature ejaculation. International Journal of Impotence Research (2001) 13, 41±45

Haidan Yuan, Qianqian Ma, Li Ye and Guangchun Piao . The Traditional Medicine and Modern Medicine from Natural Products. Molecules 2016, 21, 559; doi:10.3390/molecules21050559

Kam SC, Han DH, Lee SW. The diagnostic value of the premature ejaculation diagnostic tool and its association with intravaginal ejaculatory latency time. The journal of sexual medicine. 2011 1;8(3):865-71.

Sharma DK, Yadav R, Kewalramani S, Raj D, Sharma BN. Health status of geriatric population of a metropolitan city with their inclination towards indigenous medicine system. International Multispecialty Journal of Health .2015 Oct;1(8);31

Mosaddegh M, Shirzad M, Minaii MB, Ahmadian-Attari MM, Abbassian A, Anushiravani M. Jovārish-e Jālīnūs, the herbal treatment of gastro-esophageal reflux disease in the history of medicine. Journal of Research on History of Medicine. 2013 May 18;2.

Bakx K. The ‘eclipse’of folk medicine in western society. Sociology of Health & Illness. 1991 Mar;13(1):20-38.

Selvam A. Inventory of vegetable crude drug samples housed in botanical survey of India, Howrah. Pharmacognosy Reviews. 2008;2(3):61

Gauthaman K, Adaikan PG, Prasad RN. Aphrodisiac properties of Tribulus Terrestris extract (Protodioscin) in normal and castrated rats. Life sciences. 2002 Aug 9;71(12):1385-96.

Singh S, Nair V, Gupta YK. Evaluation of the aphrodisiac activity of Tribulus terrestris Linn. in sexually sluggish male albino rats. Journal of pharmacology & pharmacotherapeutics. 2012 Jan;3(1):43

Moghaddam MH, Khalili M, Maleki M, Abadi ME. The effect of oral feeding of Tribulus terrestris L. on sex hormone and gonadotropin levels in addicted male rats. International journal of fertility & sterility. 2013 Apr;7(1):57.

Sansalone S, Russo GI, Mondaini N, Cantiello F, Antonini G, Cai T. A combination of tryptophan, Satureja montana, Tribulus terrestris, Phyllanthus emblica extracts is able to improve sexual quality of life in patient with premature ejaculation. Archivio Italiano di Urologia e Andrologia. 2016 Oct 5;88(3):171-6.

Baldwin DS, Manson C, Nowak M. Impact of antidepressant drugs on sexual function and satisfaction. CNS drugs. 2015 Nov 1;29(11):905-13.

Dording C.M, Boyden S.D. Depression, Antidepressants, and Sexual Functioning. https://doi.org/10.1007/978-3-319-97241-1_9

Farnia V, Shirzadifar M, Shakeri J, Rezaei M, Bajoghli H, Holsboer-Trachsler E, Brand S. Rosa damascena oil improves SSRI-induced sexual dysfunction in male patients suffering from major depressive disorders: results from a double-blind, randomized, and placebo-controlled clinical trial. Neuropsychiatric disease and treatment. 2015;11:625

Hosseinzadeh H, Ziaee T, Sadeghi A. The effect of saffron, Crocus sativus stigma, extract and its constituents, safranal and crocin on sexual behaviors in normal male rats. Phytomedicine. 2008 Jun 20;15(6-7):491-5.

Shamsa A, Hosseinzadeh H, Molaei M, Shakeri MT, Rajabi O. Evaluation of Crocus sativus L.(saffron) on male erectile dysfunction: a pilot study. Phytomedicine. 2009 Aug 1;16(8):690-3.

Modabbernia A, Sohrabi H, Nasehi AA, Raisi F, Saroukhani S, Jamshidi A, Tabrizi M, Ashrafi M, Akhondzadeh S. Effect of saffron on fluoxetine-induced sexual impairment in men: randomized double-blind placebo-controlled trial. Psychopharmacology. 2012 Oct 1;223(4):381-8.

Kashani L, Raisi F, Saroukhani S, Sohrabi H, Modabbernia A, Nasehi AA, Jamshidi A, Ashrafi M, Mansouri P, Ghaeli P, Akhondzadeh S. Saffron for treatment of fluoxetine‐induced sexual dysfunction in women: randomized double‐blind placebo‐controlled study. Human Psychopharmacology: Clinical and Experimental. 2013 Jan;28(1):54-60

Mohammadzadeh-Moghadam H, Nazari SM, Shamsa A, Kamalinejad M, Esmaeeli H, Asadpour AA, Khajavi A. Effects of a topical saffron (Crocus sativus L) gel on erectile dysfunction in diabetics: A randomized, parallel-group, double-blind, placebo-controlled trial. Journal of evidence-based complementary & alternative medicine. 2015 Oct;20(4):283-6.

Lim TK. Edible Medicinal and Non-Medicinal Plants. Springer; 2016. Pp. 469-560

Bordbar H, Esmaeilpour T, Dehghani F, Panjehshahin MR. Stereological study of the effect of ginger's alcoholic extract on the testis in busulfan-induced infertility in rats. Iran J Reprod Med. 2013;11:467–472.

Akhlaghi A, Ahangari YJ, Navidshad B, Pirsaraei ZA, Zhandi M, Deldar H, et al. Improvements in semen quality, sperm fatty acids, and reproductive performance in aged Cobb 500 breeder roosters fed diets containing dried ginger rhizomes (Zingiber officinale) Poultry Sci. 2014;93:1236–1244

Ikpeme EV, Udensi OU, Ekerette EE, Okon UH. Potential of Ginger (Zingiber officinale) Rhizome and Watermelon (Citrullus lanatus) Seeds in Mitigating Aspartame-Induced Oxidative Stress in Rat Model. Res J Med Plant. 2016;10:55–66.

Busman H, Kanedi M. Testicular Function of Rats Treated with Water Extract of Red Ginger (Zingiber officinale var rubrum) Combined with Zinc. J Food Nutr Res. 2016;4:157–162.

Hafez DA. Effect of extracts of ginger roots and cinnamon bark on fertility of male diabetic rats. J Am Sci. 2014;6:940–947.

Hosseini j, Mardi Mamaghani A, Hosseinifar H, Sadighi Gilani M.A, Dadkhah F, and Sepidarkish M, The influence of ginger (Zingiber officinale) on human sperm quality and DNA fragmentation: A double-blind randomized clinical trial, Int J Reprod Biomed (Yazd). 2016 Aug; 14(8): 533–540.8

Khanavi M, Azimi H, Ghiasi S, Hassani S, Rahimi R, Nikfar S, et al. Specifying human platelet camp and cgmp phosphodiesterase inhibitory activity of the plants used in traditional Iranian medicine for the purpose of erectile dysfunction. Int J Pharmacol 2012; 8(3):161-8.

How to Cite
Ahmadian-Attari MM, Moosavi-Asil SH, Mohammad Taghizadeh Kashani L, Shirzad M. Effect of Bastibaj, a Traditional Persian Formula, on Premature Ejaculation: Observation of a Traditional Treatment. Trad Integr Med. 4(2):64-71.
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