Case Studies

Electroacupuncture (EA) Treatment for a Chronic Severe Femoral Nerve Injury: A Case Report

Abstract

Although there have been a few reports of improvement in peripheral nerve injury (PNI) with electroacupuncture (EA), this seems to be the first report of treating a patient with chronic femoral nerve injury using EA. A 35-year-old Iranian woman visited the university acupuncture clinic because of severe difficulties in hip flexion, extension of knee, and sensory loss on the medial side of leg on the right side. The diagnosis of femoral nerve injury was confirmed by physical examination and nerve conduction study (NCS). EA treatment was done three times a week for 12 sessions. A post-treatment physical examination and NCS showed improvement in the patient's motor and sensory symptoms. The patient continued to improve at the follow-up physical examination 7 months after treatment. This case report provides clinical and NCS evidence that EA may effectively treat a chronic severe femoral nerve injury.

Standring S. Gray's anatomy e-book: the anatomical basis of clinical practice: Elsevier Health Sciences. 2021.

Gibelli F, Ricci G, Sirignano A, Bailo P, De Leo D: Latrogenic femoral nerve injuries: Analysis of medico-legal issues through a scoping review approach. Ann Med Surg 2021;72:103055.

Antoniadis G, Kretschmer T, Pedro MT, König RW, Heinen CP, et al. Latrogenic nerve injuries: prevalence, diagnosis and treatment. Dtsch Ärztebl Int 2014;111:273.

Sullivan R, Dailey T, Duncan K, Abel N, Borlongan CV. Peripheral nerve injury: stem cell therapy and peripheral nerve transfer. Int J Mol Sci 2016;17:2101.

Hussain G, Wang J, Rasul A, Anwar H, Qasim M, et al. Current status of therapeutic approaches against peripheral nerve injuries: a detailed story from injury to recovery. Int J Biol Sci 2020; 16:116.

Yang Y, Rao C, Yin T, Wang S, Shi H, et al. Application and underlying mechanism of acupuncture for the nerve repair after peripheral nerve injury: remodeling of nerve system. Front Cell Neurosci 2023;17:1253438.

Inoue M. The effects of electro-acupuncture on peripheral nerve regeneration in rats. Jpn J Physical Fitn Sport Med 2003;52:391-406.

Inoue M, Katsumi Y, Itoi M, Hojo T, Nakajima M, et al. Direct current electrical stimulation of acupuncture needles for peripheral nerve regeneration: an exploratory case series. Acupunct Med 2011;29:88-93.

Narita M, Suzuki K, Ogimoto K, Ichida K, Aratake J, et al. A case series title: femoral nerve injury with an episode of motor neuropathy caused by gynecological surgery: a case series. Int Cancer Conf J 2023;12:294-298.

Stebler K, Martin R, Kirkham KR, Küntzer T, Bathory I, et al. Electrophysiological study of femoral nerve function after a continuous femoral nerve block for anterior cruciate ligament reconstruction: a randomized, controlled single-blind trial. Am J Sports Med 2017;45:578-583.

Parvizi J: High yield orthopaedics E-Book: Elsevier Health Sciences; 2010.

Moore AE, Stringer MD. Latrogenic femoral nerve injury: a systematic review. Surg Radil Anat 2011; 33:649-658.

Ni L, Yao Z, Zhao Y, Zhang T, Wang J, et al. Electrical stimulation therapy for peripheral nerve injury. Front Neurol 2023;14:1081458.

Haastert-Talini K, Schmitte R, Korte N, Klode D, Ratzka A, et al. Electrical stimulation accelerates axonal and functional peripheral nerve regeneration across long gaps. J Neurotrauma 2011; 28:661-674.

Chu X-L, Song X-Z, Li Q, Li Y-R, He F, et al. Basic mechanisms of peripheral nerve injury and treatment via electrical stimulation. Neural regeneration research 2022;17:2185.

Ahmad I, Fernando A, Gurgel R, Clark JJ, Xu L, et al. Merlin status regulates p75NTR expression and apoptotic signaling in Schwann cells following nerve injury. Neurobiol Dis 2015;82:114-122.

Chou A-K, Yang M-C, Tsai H-P, Chai C-Y, Tai M-H, et al. Adenoviral-Mediated glial cell line–derived neurotrophic factor gene transfer has a protective effect on sciatic nerve following constriction-induced spinal cord injury. PLoS One 2014;9:e92264.

Kingham PJ, Kolar MK, Novikova LN, Novikov LN, Wiberg M. Stimulating the neurotrophic and angiogenic properties of human adipose-derived stem cells enhances nerve repair. Stem Cells Dev 2014;23:741-754.

Budni J, Bellettini-Santos T, Mina F, Garcez ML, Zugno AI. The involvement of BDNF, NGF and GDNF in aging and Alzheimer’s disease. Aging Dis 2015;6:331-341.

Lopez-Leal R, Court FA. Schwann cell exosomes mediate neuron–glia communication and enhance axonal regeneration. Cell Mol Neurobiol 2016;36:429-436.

Rigoni M, Negro S. Signals orchestrating peripheral nerve repair. Cells 2020;9:1768.

Fei J, Gao L, Li H-H, Yuan Q-L, Li L-J. Electroacupuncture promotes peripheral nerve regeneration after facial nerve crush injury and upregulates the expression of glial cell-derived neurotrophic factor. Neural Regen Res 2019;14:673-682.

McGregor CE, English AW. The role of BDNF in peripheral nerve regeneration: activity-dependent treatments and Val66Met. Front Cell Neurosci 2019;12:522.

Kawamura K, Kano Y. Electrical stimulation induces neurite outgrowth in PC12m3 cells via the p38 mitogen-activated protein kinase pathway. Neurosci Lett 2019;698:81-84.

IssueVol 10, No 2, 2025 (In Press) QRcode
SectionCase Studies
Keywords
Electroacupuncture Femoral nerve Peripheral nerve injuries Case report

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How to Cite
1.
Haghir H, Bahrami-Taghanaki HR. Electroacupuncture (EA) Treatment for a Chronic Severe Femoral Nerve Injury: A Case Report. Trad Integr Med. 2025;10(2).