Review Article

A Review of "Narcissus tazetta L." in Traditional Persian Medicine and Modern Medicine

Abstract

Narcissus tazetta L., commonly known as narcissus, is a member of the Amaryllidaceae family. It has a wide distribution worldwide. Various ancient sources, including traditional Persian medicine, Unani medicine, Ayurveda, and Chinese medicine, have documented diverse and significant uses of this plant. Recent studies have also confirmed several pharmacological effects of narcissus. Our aim was to review the references about narcissus in Traditional Persian Medicine (TPM) and compare them with conventional sources. For this purpose, TPM data were extracted from Persian medicine sources; while modern data were obtained from electronic databases such as PubMed, Google Scholar, and SID. TPM sources attribute various effects to narcissus, including treatment of swellings and masses, alleviating pain, and healing of internal and external ulcers. These properties align with the antimicrobial, anticancer, and anti-aging effects reported in recent studies. The integration of ancient knowledge and modern scientific research holds promise in identifying new pharmaceutical and therapeutic approaches. Nevertheless, further studies are needed to comprehend the precise mechanisms of these effects and potential side effects.

Majd A. The study of ontogenesis structures of generatrice organe and ultra structure of pollen

grains in Narcissus Tazetta L.. J Plant Environ Physiol 2018;8:29-36.

Chehrazi M. Study of genetic diversity of exotic and endemic daffodils (Narcissus spp) using RAPD markers. Iran J Hortic Sci Technol 2008;8:225-236.

Mozafarian V. A Dictionary of Iranian Plant names. Farhang-e Moasser. Tehran 2005; p 358.

Soleimani S, Bernard F, Amini M, Khavari-nezhad R. Alkaloids from Narcissus tazetta L. J Med Plants 2007;6:58-63.

Amiri M. Dictionary of Medicines and Difficult Words. Iranian Culture Foundation. Tehran 1974; p 391.

Azodi A. Kitab al-Mia fi al-Tibb. Iran University of Medical Sciences, Institute of Medical History, Islamic and Complementary Medicine.Tehran 2008; p 1244.

IbneBaitar. Al Jamee le-Mofradat al-Adviyah va al-Agziyah. Vol 4. Dar ol -Kotob al Elmiah. Beirut 2008; p 477.

Soltani A. Encyclopedia of Traditional Medicine (medicinal plants). Tehran University of Medical Sciences Publisher. Tehran1902; p 359.

Ben-Abdallah S, Sefi M, Soudani N, Hamdi A, Bejaoui S, et al. Potential antioxidant effects of Narcissus tazetta phenolic compounds against cadmium chloride–induced hepatotoxicity in Swiss albino mice. Environ Sci Pollut Res 202;28:66193-66205.

Biruni A. Saydane fi al-Tibb. Persian Language and Literature Academy 2004; p 965.

Hippocrates. Hippocrate. Vol 7. Harvard University Press. 1994; p 91.

Dioscorides P. Al-Hashayesh. Vol 4. Tehran University of Medical Sciences. Tehran 2012; p 165.

Pliny the Elder. Naturalis Historia. Latin, ed. Mayhoff KFT. Persus Digital Library 1855.

Barghi A. Al-Mahasen. Dar ol-kotob al-eslamiah. Qom 1992; p 380.

Kashkari Y. Konash fi Tibb. Iran university of medical science. Tehran 2007; pp155-157.

Tonkaboni M. Tohfah al Momenin. Vol 1. Noor-e Vahy. Qom 2012; p 821.

Ghahreman A. Comparative description the ancient names of Medicinal Plants with scientific names. Tehran University Publication. Tehran 2009.

Heravi Q. Ershad al-Zerae. Moshiri M, editor. Tehran University Publication. Tehran 1977; p 212.

Shirazi MAA. Makhzan al- Adviah. Vol 2. Safir-e ardehal. Tehran 2018; pp 873-874.

Majoosi A. Kamil al-Sanaat al-Tibbiyah. Vol 1. Jalaleddin. Qom 2008; p 589.

Kalam MA, Qayoom I. Nargis (narcissus tazetta l.): pharmacological properties and therapeutic uses of a rare herb of unani medicine-a review. Eur J Pharm Med Res 2020;413.

TavakoliSaberi M. Dictionary of Traditional Medicine. Moin Publisher. Tehran 2016.

Heravi M. Al-Abniyah an Hagayeg al-Adviah. Tehran University Publication. Tehran 1967; p 332.

Mirheidar H. Herbal Knowledge. Vol 4. Islamic culture publishing office. Tehran 2018; p 254.

Avicenna. Al-Qanun fi al-Tibb. Vol 2. Dar ol-Ehia al-Tourath al-Arabiah. Beirut 2005; p 28.

Rhazes M. Al-Hawi fi al-Tibb. Vol 21. Dar ol-Ehia al-Tourath al-Arabih. Beirut 2002; p 427.

Soltani A. Iranian traditional medicine: A Dictionary Arabic- Persian- English. Tehran: Traditional medicine & Materia Medica Center. Tehran 2015.

Lee KP, Elston DM. Botanical Briefs: Daffodils (Narcissus Species). Cutis 2023;111:41-45.

Morovvati H, Armand N. Investigate the effect of alcoholic extract of bulbs of narcissus (Narcissus tazetta L.) on indexes of renal function. KAUMS Journal (FEYZ) 2020;24:56-62.

Chi-Fai W. The biological activities of narciclasine [MSc thesis]. The Chinese University of Hong Kong; 2002.

Karakoyun Ç, Bozkurt B, Çoban G, Masi M, Cimmino A, et al. A comprehensive study on Narcissus tazetta subsp. tazetta L.: Chemo-profiling, isolation, anticholinesterase activity and molecular docking of Amaryllidaceae alkaloids. S Afr J Bot 2020;130:148-154.

Al-Snafi AE. Constituents and pharmacology of Narcissus tazetta. IOSR J Pharm 2020;10:44-53.

Bastida Armengol J, Berkov S, Torras Claveria L, Pigni NB, Andrade JPd, et al. Chemical and biological aspects of Amaryllidaceae alkaloids. Recent Advances in Pharmaceutical Sciences. India 2011;65-100.

Hanks GR. The biology of Narcissus. In: Narcissus and Daffodil. CRC Press 2002; pp 21-38.

Habartova K, Cahlíková L, Řezáčová M, Havelek R. The biological activity of alkaloids from the Amaryllidaceae: from cholinesterases inhibition to anticancer activity. Nat Prod Commun 2016;11:1587-1594.

López S, Bastida J, Viladomat F, Codina C. Acetylcholinesterase inhibitory activity of some Amaryllidaceae alkaloids and Narcissus extracts. Life Sci 2002;71:2521-2529.

Karimi M. Investigating the effect of alchoholic extract of Narcissus onion on ethanol induced amnesia in rats. Iran Plant Biotechnol 2012;8:33-42.

Kornienko A, Evidente A. Chemistry, biology, and medicinal potential of narciclasine and its congeners. Chem Rev 2008;108:1982-2014.

Fitzgerald D, Hartwell J, Leiter J. Tumor-damaging activity in plant families showing antimalarial activity. Amaryllidaceae. J Natl Cancer Inst 1958;20:763-774.

Bi Y-R, Yung K-H, Wong Y-S. Physiological effects of narciclasine from the mucilage of Narcissus tazetta L. bulbs. Plant Sci 1998;135:103-108.

Chu KT, Ng TB. First report of a glutamine-rich antifungal peptide with immunomodulatory and antiproliferative activities from family Amaryllidaceae. Biochem Biophys Res Commun 2004;325:167-173.

Li L, Dai H-J, Ye M, Wang S-L, Xiao X-J, et al. Lycorine induces cell-cycle arrest in the G0/G1 phase in K562 cells via HDAC inhibition. Cancer Cell Int 2012;12:1-6.

Liu J, Li Y, Ren W, Hu W-X. Apoptosis of HL-60 cells induced by extracts from Narcissus tazetta var. chinensis. Cancer lett 2006;242:133-140.

Liu J, Hu W-X, He L-F, Ye M, Li Y. Effects of lycorine on HL-60 cells via arresting cell cycle and inducing apoptosis. FEBS lett 2004;578:245-250.

Dumont P, Ingrassia L, Rouzeau S, Ribaucour F, Thomas S, et al. The Amaryllidaceae isocarbostyril narciclasine induces apoptosis by activation of the death receptor and/or mitochondrial pathways in cancer cells but not in normal fibroblasts. Neoplasia 2007;9:766-776.

Hu M, Peng S, He Y, Qin M, Cong X, et al. Lycorine is a novel inhibitor of the growth and metastasis of hormone-refractory prostate cancer. Oncotarget 2015;6:15348-15361.

Shawky E, Abou-Donia AH, Darwish FA, Toaima SM, Takla SS, et al. In vitro cytotoxicity of some Narcissus plants extracts. Nat Prod Res 2015;29:363-365.

Morikawa T, Ninomiya K, Kuramoto H, Kamei I, Yoshikawa M, et al. Phenylethanoid and phenylpropanoid glycosides with melanogenesis inhibitory activity from the flowers of Narcissus tazetta var. chinensis. J Nat Med 2016;70:89-101.

Yuan Y, He X, Li X, Liu Y, Tang Y, et al. Narciclasine induces autophagy-mediated apoptosis in gastric cancer cells through the Akt/mTOR signaling pathway. BMC Pharmacol Toxicol 2021;22:1-11.

Furusawa E, Furusawa S, Morimoto S, Cutting W. Therapeutic activity of Narcissus alkaloid on Rauscher leukemia and comparison with standard drugs. Proc Soc Exp Biol Med 1971;136:1168-1173.

Furusawa E, Suzuki N, Tani S, Furusawa S, Ishioka G, et al. Anticancer activity of Narcissus extracts in mice. Proc Soc Exp Biol Med 1973;143:33-38.

Ceriotti G. Narciclasine: an antimitotic substance from Narcissus bulbs. Nature 1967;213:595-596.

Tariq H, Rafi M, Amirzada MI, Muhammad SA, Yameen MA, et al. Photodynamic cytotoxic and antibacterial evaluation of Tecoma stans and Narcissus tazetta mediated silver nanoparticles. Arab J Chem 2022;15:103652.

Talib WH, Mahasneh AM. Antimicrobial, cytotoxicity and phytochemical screening of Jordanian plants used in traditional medicine. Molecules 2010;15:1811-1824.

Gabrielsen B, Monath TP, Huggins JW, Kefauver DF, Pettit GR, et al. Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances. J Nat Prod 1992;55:1569-1581.

Ooi LS, Ho WS, Ngai KL, Tian L, Chan PK, Sun SS, et al. Narcissus tazetta lectin shows strong inhibitory effects against respiratory syncytial virus, influenza A (H1N1, H3N2, H5N1) and B viruses. J Biosci 2010;35:95-103.

Kelling CL, Schipper IA, Schermeister LJ, Vacik JP. Effects of crude extracts of various plants on infectious bovine rhinotracheitis virus-plaque production. Am J Vet Res 1976;37:215-218.

Papas T, Sandhaus L, Chirigos M, Furusawa E. Inhibition of DNA polymerase of avian myeloblastosis virus by an alkaloid extract from Narcissus tazetta L. Biochem Biophys Res Commun 1973;52:88-92.

Sarkar A, Paul S, Singh C, Chowdhury N, Nag P, et al. A novel plant lectin, NTL-125, interferes with SARS-CoV-2 interaction with hACE2. Virus Res 2022;315:198768.

Şener B, Orhan I, Satayavivad J. Antimalarial activity screening of some alkaloids and the plant extracts from Amaryllidaceae. Phytother Res 2003;17:1220-1223.

Sener B, Koyuncu M, Bingöl F, Muhtar F. Production of bioactive alkaloids from Turkish geophytes. Pure Appl Chem 1998;70:2131.

Fu K-L, Li X, Ye J, Lu L, Xu X-K, et al. Chemical constituents of Narcissus tazetta var. chinensis and their antioxidant activities. Fitoterapia 2016;113:110-116.

Rameshk M, Sharififar F, Mehrabani M, Pardakhty A, Farsinejad A. In vitro proliferation and wound healing effects of Narcissus tazetta L. bulb on primary human dermal fibroblasts. J Pharm Res Int 2018;20:1-11.

Havas F, Krispin S, Borenstein-Auerbach N, Loing E, editors. Narcissus tazetta bulb extract delays cellular senescence by reducing mTOR pathway activation. Journal of Investigative Dermatology 2020;140:S29.

Namkoong J, Kern D, Knaggs HE. Assessment of human skin gene expression by different blends of plant extracts with implications to periorbital skin aging. Int J Mol Sci 2018;19:3349.

Chiu K, Lee Y, Yung K. Bioactive substances from the Chinese daffodil, Narcissus tazetta. Phytother Res 1992;6:231-236.

Cakici I, Ulug HY, Inci S, Tunçtan B, Abacioglu N, et al. Antinociceptive effect of some amaryllidaceae plants in mice. J Pharm Pharmacol 1997;49:828-830.

Sinha M, Singh A, Shokeen A, Sharma P, Kaushik S, et al. Evidence of a novel allergenic protein Narcin in the bulbs of Narcissus tazetta. Int J Biochem Mol Biol 2013;4:95.

Files
IssueVol 9, No 2, 2024 QRcode
SectionReview Article(s)
DOI https://doi.org/10.18502/tim.v9i2.15875
Keywords
Narcissus tazetta Amaryllidaceae Persian Medicine Iranian traditional medicine Therapeutic

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
1.
Gholami P, Mokaberinejad R, Hamzeloo-Moghadam M, Heidarirad G, Sadeghi S, Khodadoost M. A Review of "Narcissus tazetta L." in Traditional Persian Medicine and Modern Medicine. Trad Integr Med. 2024;9(2):219-226.