Lifestyle Modification in Respiratory Tract Inflammation: Persian Medicine Perspective
Abstract
Excessive inflammation in the respiratory system could lead to life-threatening conditions. This situation is usually caused by irritants, allergens, pathogens, toxins, and pollutants, leading to airway inflammation. On the other hand, an inappropriate lifestyle can cause inflammation in different parts of the body including the respiratory tract. This study aimed to explore the recommended lifestyle modification for respiratory tract inflammation from the Persian medicine viewpoint in light of current evidence. In this review, first, we looked for lifestyle factors effective on the respiratory tract in Persian medicine sources. Then, PubMed, Web of Science, and Google Scholar were searched to find evidence about the mentioned factors, using the following keywords: psychological stress, sleep, food, exercise, gut, constipation, cold, and airway or respiratory tract. In line with Persian medicine, current literature confirms that psychological stress, intensive physical activity, allergic foods, and cold ambient trigger the beginning of the inflammation process in the respiratory system. It could happen through different pathways such as downregulation of Th1 cytokines expression, cold-inducible RNA binding protein (CIRP) synthesizing, mucin 5AC (MUC5AC) overexpression, activating transient receptor potential melastatin 8 (TRPM8) channels, inducing a neutrophilic type of inflammation and damaging the airway epithelium. Mild exercise, well-being of the gut microbiota status, and reduction of sleep duration have beneficial effects on the regression of inflammation. Lifestyle modification could play an important role in the prevention and treatment of respiratory tract inflammation. Future clinical investigations should be conducted to evaluate their effects.
Ahmed AU. An overview of inflammation: mechanism and consequences. Front Biol 2011;6:274-281.
Aghasafari P, George U, Pidaparti R. A review of inflammatory mechanism in airway diseases. J Inflamm Res 2019;68:59-74.
Ward PA. Acute lung injury: how the lung inflammatory response works. Eur J Respir 2003;44:22s-23s.
Lee G, Walser TC, Dubinett SM. Chronic inflammation, chronic obstructive pulmonary disease, and lung cancer. Curr Opin Pulm Med 2009;15:303-307.
Vieira RP, Toledo AC, Ferreira SC, Santos AB, Medeiros MC, et al. Airway epithelium mediates the anti-inflammatory effects of exercise on asthma. Respir Physiol Neurobiol 2011;175:383-389.
Yuksel H, Turkeli A. Airway epithelial barrier dysfunction in the pathogenesis and prognosis of respiratory tract diseases in childhood and adulthood. Tissue Barriers 2017;5:e1367458.
Strasser B, Wolters M, Weyh C, Krüger K, Ticinesi A. The Effects of Lifestyle and Diet on Gut Microbiota Composition, Inflammation and Muscle Performance in Our Aging Society. Nutrients 2021;13:6.
Ambrosino N, Bertella E. Lifestyle interventions in prevention and comprehensive management of COPD. Breathe 2018;14:186-194.
Mark JD, Chung Y. Complementary and alternative medicine in pulmonology. Curr Opin Pediatr 2015;27:334-340.
Kheirypour A, Moini Jazani A, Hashempur MH, Ghobadi-Marallu H, Nasimi Doost Azgomi R. Complementary and Alternative Medicine Use and Its Determinant Factors in Iranian Asthma and Chronic Obstructive Pulmonary Disease Patients. Trad Integr Med 2023;8:379-388.
Tabish SA. Complementary and Alternative Healthcare: Is it Evidence-based? Int J Health Sci 2008;2:V-ix.
Barnes PM, Powell-Griner E, McFann K, Nahin RL. Complementary and alternative medicine use among adults: United States, 2002. Adv Data 2004;343:1-19.
Sadr S, Tahermohammadi H, Kaveh S. Investigation the lifestyle in patients with cystic fibrosis according to iranian traditional medicine. Int J Pediatr 2021;9:13551-13557.
IbnSina AAHiA. Al Qanoun fe Al teb Al elmy al matbouat Institute, Lebanon 2005.
Shah-Arzani MA. Tib-e-Akbari. Jalal-ed-Din. Ghom 2008; p 879.
Jorjani S. Zakhireh Kharazmshahi, Vol. 11, corrected by Moharrari MR.
Azam khan M. Exir Azam (Great Elixir) [in Persian]. India: Monshi Nou, 1869.M.
Aghili khorasani MH. Kholasa't ol Hikma'(persian). Ismaeelian. Qom 2005; pp 233-235.
Hajihoseini M, Tahermohammadi H, Daneshfard B, Safari MS, Karimi Rouzbahani A. Massage with herbal oils as a novel therapeutic approach for cerebral palsy: a medical hypothesis. Trad Integr Med 2023;8:408-418.
Okuyama K, Ohwada K, Sakurada S, Sato N, Sora I, et al. The distinctive effects of acute and chronic psychological stress on airway inflammation in a murine model of allergic asthma. Allergol Int 2007;56:29-35.
Miller GE, Cohen S, Ritchey AK. Chronic psychological stress and the regulation of pro-inflammatory cytokines: a glucocorticoid-resistance model. Health Psychol 2002;21:531-541.
Drolet G, Dumont EC, Gosselin I, Kinkead R, Laforest S, et al. Role of endogenous opioid system in the regulation of the stress response. Prog Neuropsychopharmacol Biol Psychiatry 2001;25:729-741.
McLaughlin JP, Marton-Popovici M, Chavkin C. Kappa opioid receptor antagonism and prodynorphin gene disruption block stress-induced behavioral responses. J Neurosci 2003;23:5674-583.
Makarenkova VP, Esche C, Kost NV, Shurin GV, Rabin BS, et al. Identification of delta and mu-type opioid receptors on human and murine dendritic cells. J Neuroimmunol 2001;117:68-77.
Wang J, Charboneau R, Barke RA, Loh HH, Roy S. Mu-opioid receptor mediates chronic restraint stress-induced lymphocyte apoptosis. J Immunol 2002;169:3630-3636.
Tseng RJ, Padgett DA, Dhabhar FS, Engler H, Sheridan JF. Stress-induced modulation of NK activity during influenza viral infection: role of glucocorticoids and opioids. Brain Behav Immun 2005;19:153-164.
Sacerdote P, Manfredi B, Gaspani L, Panerai AE. The opioid antagonist naloxone induces a shift from type 2 to type 1 cytokine pattern in BALB/cJ mice. Blood 2000;95:2031-2036.
Roy S, Wang J, Gupta S, Charboneau R, Loh HH, et al. Chronic morphine treatment differentiates T helper cells to Th2 effector cells by modulating transcription factors GATA 3 and T-bet. J Neuroimmunol 2004;147:78-81.
Liu LY, Coe CL, Swenson CA, Kelly EA, Kita H, et al. School examinations enhance airway inflammation to antigen challenge. Am J Respir Crit Care Med 2002;165:1062-1067.
Forsythe P, Ebeling C, Gordon JR, Befus AD, Vliagoftis H. Opposing effects of short- and long-term stress on airway inflammation. Am J Respir Crit Care Med 2004;169:220-226.
Joachim RA, Quarcoo D, Arck PC, Herz U, Renz H, et al. Stress enhances airway reactivity and airway inflammation in an animal model of allergic bronchial asthma. Psychosom Med 2003;65:811-815.
de Paula Portela C, de Oliveira Massoco C, de Lima WT, Palermo-Neto J. Stress-induced increment on total bronchoalveolar cell count in OVA-sensitized rats. Physiol Behav 2001;72:415-420.
Wright RJ, Cohen RT, Cohen S. The impact of stress on the development and expression of atopy. Curr Opin Allergy Clin Immunol 2005;5:23-29.
James JM. Food allergy and the respiratory tract. Curr Allergy Rep 2001;1:54-60.
Borisova IV, Smirnova SV. The peculiarities of food allergies in accordance with the level of injury of respiratory tract in children of Eastern Siberia. Int J Circumpolar Health 2013;72.
Cholewa JM, Paolone VJ. Influence of exercise on airway epithelia in cystic fibrosis: a review. Med Sci Sports Exerc 2012;44:1219-1226.
Kippelen P, Anderson SD. Airway injury during high-level exercise. Br J Sports Med 2012;46:385-390.
Davis MS, Lockard AJ, Marlin DJ, Freed AN. Airway cooling and mucosal injury during cold weather exercise. Equine Vet J Suppl 2002:413-416.
Seys SF, Daenen M, Dilissen E, Van Thienen R, Bullens DM, et al. Effects of high altitude and cold air exposure on airway inflammation in patients with asthma. Thorax 2013;68:906-913.
D’Amato M, Molino A, Calabrese G, Cecchi L, Annesi-Maesano I, et al. The impact of cold on the respiratory tract and its consequences to respiratory health. Clin Transl Allergy 2018;8:20.
Xing H, Ling JX, Chen M, Johnson RD, Tominaga M, et al. TRPM8 mechanism of autonomic nerve response to cold in respiratory airway. Mol Pain 2008;4:22.
Chen L, Ran D, Xie W, Xu Q, Zhou X. Cold-inducible RNA-binding protein mediates cold air inducible airway mucin production through TLR4/NF-κB signaling pathway. Int Immunopharmacol 2016;39:48-56.
Naumov DE, Perelman JM, Kolosov VP, Potapova TA, Maksimov VN, et al. Transient receptor potential melastatin 8 gene polymorphism is associated with cold-induced airway hyperresponsiveness in bronchial asthma. Respirology 2015;20:1192-7.
Liu H, Hua L, Liu Q, Pan J, Bao Y. Cold Stimuli Facilitate Inflammatory Responses Through Transient Receptor Potential Melastatin 8 (TRPM8) in Primary Airway Epithelial Cells of Asthmatic Mice. Inflammation 2018;41:1266-1275.
Renegar KB, Crouse D, Floyd RA, Krueger J. Progression of influenza viral infection through the murine respiratory tract: the protective role of sleep deprivation. Sleep 2000;23:859-863.
Zhang YLT, Yuan H, Pan W, Dai Q. Correlations of inflammatory factors with intestinal flora and gastrointestinal incommensurate symptoms in children with asthma. Med Sci Monit 2018;24:7975-7979.
Vital M, Harkema JR, Rizzo M, Tiedje J, Brandenberger C. Alterations of the murine gut microbiome with age and allergic airway disease. J Immunol Res 2015;2015:892568.
Kim YG, Udayanga KG, Totsuka N, Weinberg JB, Núñez G, et al. Gut dysbiosis promotes M2 macrophage polarization and allergic airway inflammation via fungi-induced PGE₂. Cell Host Microbe 2014;15:95-102.
Chiu CY, Chan YL, Tsai MH, Wang CJ, Chiang MH, et al. Gut microbial dysbiosis is associated with allergen-specific IgE responses in young children with airway allergies. World Allergy Organ J 2019;12:100021.
Abdolahinia A, Naseri M, Tahmasbi S, Adimi P, Sadr M, et al. Ideal Lifestyle to Have Healthy Lungs: Persian Medicine Viewpoint. Trad Integr Med 2022;7:150-158.
Buske-Kirschbaum A, von Auer K, Krieger S, Weis S, Rauh W, et al. Blunted cortisol responses to psychosocial stress in asthmatic children: a general feature of atopic disease? Psychosom Med 2003;65:806-810.
Okuyama K, Wada K, Sakurada S, Mizoguchi H, Komatsu H, et al. The involvement of micro-opioid receptors in the central nervous system in the worsening of allergic airway inflammation by psychological stress in mice. Int Arch Allergy Immunol 2010;152:342-352.
Miyasaka T, Okuyama-Dobashi K, Masuda C, Iwami S, Sato M, et al. The involvement of central nervous system histamine receptors in psychological stress-induced exacerbation of allergic airway inflammation in mice. Allergol Int 2016;65:S38-44.
Wallaert B, Gosset P, Lamblin C, Garcia G, Perez T, et al. Airway neutrophil inflammation in nonasthmatic patients with food allergy. Allergy 2002;57:405-410.
Kulkarni N, Ragazzo V, Costella S, Piacentini G, Boner A, et al. Eosinophilic airway inflammation is increased in children with asthma and food allergies. Pediatr Allergy Immunol 2012;23:28-33.
Krogulska A, Dynowski J, Jędrzejczyk M, Sardecka I, Małachowska B, et al. The impact of food allergens on airway responsiveness in schoolchildren with asthma: A DBPCFC study. Pediatr Pulmonol 2016;51:787-795.
Hallstrand TS, Moody MW, Aitken ML, Henderson WR, Jr. Airway immunopathology of asthma with exercise-induced bronchoconstriction. J Allergy Clin Immunol 2005;116:586-593.
Jones CU, Kluayhomthong S, Chaisuksant S, Khrisanapant W. Breathing exercise using a new breathing device increases airway secretion clearance in mechanically ventilated patients. Heart Lung 2013;42:177-182.
Simpson AJ, Romer LM, Kippelen P. Exercise-induced dehydration alters pulmonary function but does not modify airway responsiveness to dry air in athletes with mild asthma. J Appl Physiol (1985) 2017;122:1329-1335.
Prossegger J, Huber D, Grafetstätter C, Pichler C, Braunschmid H, et al. Winter exercise reduces allergic airway inflammation: a randomized controlled study. Int J Environ Res Public Health 2019;16:2040.
Vendrusculo FM, Johnstone Z, Dhouieb E, Donadio MVF, Cunningham S, et al. Airway clearance physiotherapy improves ventilatory dynamics during exercise in patients with cystic fibrosis: a pilot study. Arch Dis Child 2019;104:37-42.
Davidson WJ, Verity WS, Traves SL, Leigh R, Ford GT, et al. Effect of incremental exercise on airway and systemic inflammation in patients with COPD. J Appl Physiol 2012;112:2049-2056.
Evaristo KB, Saccomani MG, Cukier A, Stelmach R, Carvalho-Pinto R, et al. Effects of aerobic and breathing exercises on clinical control and airway inflammation in persistent asthma. Eur Respir J 2017;50:OA2919.
Scott HA, Gibson PG, Garg ML, Pretto JJ, Morgan PJ, et al. Dietary restriction and exercise improve airway inflammation and clinical outcomes in overweight and obese asthma: a randomized trial. Clin Exp Allergy 2013;43:36-49.
Sabnis AS, Reilly CA, Veranth JM, Yost GS. Increased transcription of cytokine genes in human lung epithelial cells through activation of a TRPM8 variant by cold temperatures. Am J Physiol Lung Cell Mol Physiol 2008;295:L194-200.
Mäkinen TM, Juvonen R, Jokelainen J, Harju TH, Peitso A, et al. Cold temperature and low humidity are associated with increased occurrence of respiratory tract infections. Respir Med 2009;103:456-462.
Juan Y, Haiqiao W, Xie W, Huaping H, Zhong H, et al. Cold-inducible RNA-binding protein mediates airway inflammation and mucus hypersecretion through a post-transcriptional regulatory mechanism under cold stress. Int J Biochem Cell Biol 2016;78:335-348.
Stjernbrandt A, Stenfors N, Liljelind I. Occupational cold exposure is associated with increased reporting of airway symptoms. Int Arch Occup Environ Health 2021;94:1945-1952.
Sazak Kundi FC, Murat Ozcan K, Okudan B, Coskun N, Inan MA, et al. Effects of chronic sleep deprivation on upper respiratory tract mucosal histology and mucociliary clearance on rats. J Sleep Res 2021;30:e13065.
Trompette A, Gollwitzer ES, Yadava K, Sichelstiel AK, Sprenger N, et al. Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis. Nat Med 2014;20:159-166.
Kepert I, Fonseca J, Müller C, Milger K, Hochwind K, Kostric M, et al. D-tryptophan from probiotic bacteria influences the gut microbiome and allergic airway disease. J Allergy Clin Immunol 2017;139:1525-1535.
Zhang Y, Li T, Yuan H, Pan W, Dai Q. Correlations of inflammatory factors with intestinal flora and gastrointestinal incommensurate symptoms in children with asthma. Med Sci Monit 2018;24:7975-7979.
Zhang J, Ma JY, Li QH, Su H, Sun X. Lactobacillus rhamnosus GG induced protective effect on allergic airway inflammation is associated with gut microbiota. Cell Immunol 2018;332:77-84.
Wu MC, Jan MS, Chiou JY, Wang YH, Wei JC. Constipation might be associated with risk of allergic rhinitis: a nationwide population-based cohort study. PLoS One 2020;15:e0239723.
Chiu CY, Chan YL, Tsai MH, Wang CJ, Chiang MH, et al. Cross-talk between airway and gut microbiome links to IgE responses to house dust mites in childhood airway allergies. Sci Rep 2020;10:13449.
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Issue | Vol 9, No 3, 2024 | |
Section | Review Article(s) | |
DOI | https://doi.org/10.18502/tim.v9i3.16538 | |
Keywords | ||
Lifestyle Airway Respiratory tract Persian Medicine |
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