Effects of Galbanum Oil on Patients with Knee Osteoarthritis: A Randomized Controlled Clinical Trial

  • Seyede Zahra Emami-Razavi Department of Physical Medicine and Rehabilitation, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
  • Majid Khamessi Department of Physical Medicine and Rehabilitation, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran
  • Bijan Forough Department of Physical Medicine and Rehabilitation, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran
  • Mehrdad Karimi Department of Traditional Medicine, School of Traditional Medicine, Tehran University of Medical Sciences, Tehran, Iran
  • Korosh Mansoori Department of Physical Medicine and Rehabilitation, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran
  • Simin Sajadi Department of Physical Medicine and Rehabilitation, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran
  • Mohadeseh Azadvari Department of Physical Medicine and Rehabilitation, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
Keywords: Ferula gummosa, Galbanum oil, Knee osteoarthritis, Pain, Morning stiffness

Abstract

Knee osteoarthritis is considered as a major public health issue causing chronic disability worldwide with the increasing number of aging people. Many sufferers with knee osteoarthritis are using complementary and alternative medicine including herbal drug, herbal patch, etc. This research aimed to compare the efficacy of galbanum oil in the management of knee osteoarthritis with diclofenac gel using parallel randomized controlled design. In this randomized controlled trial (RCT), 32 patients with chronic knee pain due to osteoarthritis were randomly allocated into two equal groups. The intervention group received topical galbanum oil and control group received topical diclofenac gel. The drugs were given for 1 month, 3 times per day. Outcomes were assessed using Persian version of Western Ontario McMaster University Osteoarthritis Index (WOMAC) and visual analog scale (VAS). No statistically significant difference was observed between the topical galbanum oil and topical diclofenac gel regarding knee pain, morning stiffness and physical function over the 1- and 2-months follow-up period. It seems that using topical galbanum oil is clinically effective for patients suffering from knee osteoarthritis in order to decrease their pain, morning stiffness and limited function; its effect is comparable with topical diclofenac gel. Considering lesser side effects of galbanum and its herbal base, it may be a better choice compared to topical diclofenac in management of the pain of knee osteoarthritis at least in short term.

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Published
2016-10-04
How to Cite
1.
Emami-Razavi SZ, Khamessi M, Forough B, Karimi M, Mansoori K, Sajadi S, Azadvari M. Effects of Galbanum Oil on Patients with Knee Osteoarthritis: A Randomized Controlled Clinical Trial. Trad Integr Med. 1(3):101-107.
Section
Research Article(s)