Identification of Effective Medicinal Plants for Hyperlipidemia: An Ethnobotanical Study in Lorestan Province, West of Iran
AbstractIn the recent decades, hyperlipidemia has considerably increased with the development of machine life. It has been accompanied by diseases such as hypothyroidism, liver and kidney diseases, diabetes, chronic kidney disease, as well as obesity and can cause complications such as atherosclerosis, hypertension, increased risk of stroke, and fatty liver disease. Lorestan province in the west of Iran has an ancient history in traditional medicine and abundance of medicinal plants. So, this study aimed to identify effective medicinal plants for hyperlipidemia in this province and report its effects on the treatment of hyperlipidemia and the related diseases. This study was conducted during 2008-2010 by 11 trained health volunteers with the cooperation of Food and Drug Chancellor, Razi Herbal Medicine Research Center, and Health and Treatment Networks of Khorramabad, Dorud, Poldokhtar, Boroujerd, Aleshtar, Aligoodarz, Kouhdasht, and Noorabad. Questionnaire method was used, and a specific questionnaire was designed to gather information on traditional herbal therapy, which has been used to reduce hyperlipidemia in this province. The results of the questionnaire analysis indicated that in lorestan province, nine species of medicinal plants from eight plant families were used for treating hyperlipidemia. Leaves were mostly used plant part (42%) and predominantly used herbal preparations were raw plants (46%). Summer with 38% of frequency was the most reported season for collecting medicinal plants effective for hyperlipidemia in this province. Cichorium intybus was the most frequently used medicinal plant (73.33%). Novel scientific studies support the ethnomedicinal use of some of the mentioned plants in the lorestan province of Iran for the treatment of hyperlipidemia. However, further clinical investigations are needed to confirm their efficacy and safety.
Tajfard M, Ghayour Mobarhan M, Rahimi HR, Mouhebati M, Esmaeily H, Ferns GA, et al. Anxiety, depression, coronary artery disease and diabetes mellitus; an association study in Ghaem Hospital, Iran. Iran Red Crescent Med J 2013; 16(9): e14589.
Bastien M, Poirier P, Lemieux I, Despres JP. Overview of epidemiology and contribution of obesity to cardiovascular disease. Prog Cardiovasc Dis 2014; 56(4): 369-81.
Latifi S, Rashidi H, Payami S. Prevalence of Hyperlipidemia in Adolescents 10-19 Years old, Ahvaz, 2009-2010. Iran J Endocrinol Metab 2014; 16(2): 81-7. [In Persian].
Marrie RA, Reider N, Cohen J, Stuve O, Trojano M, Cutter G, et al. A systematic review of the incidence and prevalence of cardiac, cerebrovascular, and peripheral vascular disease in multiple sclerosis. Mult Scler 2015; 21(3): 318-31.
Jokinen E. Obesity and cardiovascular disease. Minerva Pediatr 2015; 67(1): 25-32.
Asadi-Samani M, Rafieian-Kopaei M, Azimi N. Gundelia: a systematic review of medicinal and molecular perspective. Pak J Biol Sci 2013; 16(21): 1238-47.
Rafieian-Kopaei M. Medicinal plants and the human needs. J HerbMed Pharmacol 2012; 1(1): 1-2.
Mohagheghzadeh A, Zargaran A, Daneshamuz S. Cosmetic sciences from ancient Persia. Pharm Hist (Lond) 2011; 41(2): 18-23.
Zargaran A. Ancient Persian medical views on the heart and blood in the Sassanid era (224-637 AD). Int J Cardiol 2014; 172(2): 307-12.
Zarshenas MM, Zargaran A, Abolhassanzadeh Z, Vessal K. Jorjani (1042-1137). J Neurol 2012; 259(12): 2764-5.
Dalfardi B, Yarmohammadi H, Sedighi M, Zargaran A. Al-Akhawayni and the early descriptions of meningitis. J Hist Neurosci 2014; 23(2): 120-6.
Zargaran A, Mehdizadeh A, Zarshenas MM, Mohagheghzadeh A. Avicenna (980-1037 AD). J Neurol 2012; 259(2): 389-90.
Carazzone C, Mascherpa D, Gazzani G, Papetti A. Identification of phenolic constituents in red chicory salads (Cichorium intybus) by high- performance liquid chromatography with diode array detection and electrospray ionisation tandem mass spectrometry. Food Chem 2013; 138(2-3): 1062-71.
Bais HP, Ravishankar GA. Cichorium intybus L – cultivation, processing, utility, value addition and biotechnology, with an emphasis on current status and future prospects. Journal of the Science of Food and Agriculture 2001; 81(5): 467-84.
Kusch U, Greiner S, Steininger H, Meyer AD, Corbiere-Divialle H, Harms K, et al. Dissecting the regulation of fructan metabolism in chicory (Cichorium intybus) hairy roots. New Phytol 2009; 184(1): 127-40.
Kim M. The water-soluble extract of chicory reduces holesterol uptake in gut-perfused rats. Nutrition Research 2000; 20(10177): 26.
Cha J, Park C, Cho YS. Hepatoprotective effect of chicory (Chicorium intybus ) root extract against orotic acid-induced fatty liver in rats. Food Science and Biotechnology 2010; 19(4): 865-71.
Amrani S, Harnafi H, Bouanani NH, Aziz M, Caid HS, Manfredini S, et al. Hypolipidaemic activity of aqueous Ocimum basilicum extract in acute hyperlipidaemia induced by triton WR-1339 in rats and its antioxidant property. Phytother Res 2006; 20(12): 1040-5.
Mirhosseini M, Baradaran A, Rafieian-Kopaei M. Anethum graveolens and hyperlipidemia: A randomized clinical trial. J Res Med Sci 2014; 19(8): 758-61.
Bennani-Kabchi N, Fdhil H, Cherrah Y, Kehel L, el Bouayadi F, Amarti A, et al. Effects of Olea europea var. oleaster leaves in hypercholesterolemic insulin-resistant sand rats. Therapie 1999; 54(6): 717-23.
Nassiri-Asl M, Zamansoltani F, Abbasi E, Daneshi MM, Zangivand AA. Effects of Urtica dioica extract on lipid profile in hypercholesterolemic rats. Zhong Xi Yi Jie He Xue Bao 2009; 7(5): 428-33.