Traditional and Integrative Medicine 2016. 1(1):3-17.

The Efficacy of Iranian Traditional and Folk Medicinal Plants for Some Gastroduodenal Disorders
Malihe Safavi, Mohammad Reza Shams-Ardakani, Maryam Sadat-Seyedbagheri, Alireza Foroumadi


Peptic ulcer and gastritis are common and universal disease which affect up to 50% of the world’s adult population. Helicobacter pylori is a major cause of chronic-active gastritis and primary duodenal ulcers, and is strongly linked to gastric cancer. H. pylori induce chronic gastritis in virtually all infected patients. Chronic gastritis induced by H. pylori increases the risk for a wide spectrum of clinical outcomes, ranging from peptic ulcer disease and atrophic gastritis to gastric adenocarcinoma and gastric mucosal lymph proliferative diseases. Extracts of several plants including Cinnamomum zeylanicum, Coriandrum sativum, Malus domestica, Phyllanthus emblica, Pistacia lentiscus, Portulaca oleracea, Punica granatum, and Terminalia chebula have been used in Iranian traditional medicine as therapeutic agents for gastritis and peptic ulcer diseases. The information on all of these remedies was derived from all available old sources such as traditional books. According to new database the mechanisms of action for some of these plants are known. For example T. chebula causes improvement in the secretory status of Brunner’s gland and also, aqueous extracts of this plant have anti-bacterial activity against H. pylori. The information of more recent studied Iranian folk medicinal plants such as Camellia sinensis, Geum iranicum, Rheum ribes, Salvia mirzayanii, Sambucus ebulus, Stachys lavandulifolia, Stachys setifera, Trachyspermum copticum, and Zataria multiflora are presented in this review. The medicinal properties of these folk plants are attributed mainly to the presence of natural anti-oxidants and potent anti H. pylori activity. It is suggested that an evaluation of the effects of these plants on different aspects of gastric disorders should be performed and further studies are necessary on the other traditional and folk medicinal plants of Iran.


Traditional Medicine; Gastritis; Peptic Ulcer; Helicobacter pylori; Iran; Medicinal Plant

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Balunas MJ, Kinghorn AD. Drug discovery from medicinal plants. Life Sci 2005; 78(5): 431-41.

Cragg GM, Newman DJ. International collaboration in drug discovery and development from natural sources. Pure Appl Chem 2005; 77(11): 1923-42.

Douglas KA. Pharmacognosy in the 21st century. J Pharm Pharmacol 2001; 53(2): 135-48.

Farnsworth NR, Akerele O, Bingel AS, Soejarto DD, Guo Z. Medicinal plants in therapy. Bull World Health Organ 1985; 63(6): 965-81.

Bai RL, Paull KD, Herald CL, Malspeis L, Pettit GR, Hamel E. Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin. Discovery of tubulin-based mechanism of action by analysis of differential cytotoxicity data. J Biol Chem 1991;266(24): 15882-9.

Newman DJ, Cragg GM, Snader KM. The influence of natural products upon drug discovery. Nat Prod Rep 2000; 17(3): 215-34.

Ebule IA, Longdoh AN, Paloheimo IL. Helicobacter pylori infection and atrophic gastritis. Afr Health Sci 2013; 13(1): 112-7.

Mahadeva S, Goh KL. Epidemiology of functional dyspepsia: a global perspective. World J Gastroenterol 2006; 12(17): 2661-6.

di Mario F, Franze A, .Cavallaro LG. A non- invasive approach to diagnosis of upper gastrointestinal diseases. Milano MI: Via Comelico; 2008. p. 5-64.

Sande N, Nikulin M, Nilsson I, Wadstrom T, Laxen F, Harkonen M, et al. Increased risk of developing atrophic gastritis in patients infected with CagA+ Helicobacter pylori. Scand J Gastroenterol 2001; 36(9): 928-33.

Hansson LE, Nyren O, Hsing AW, Bergstrom R, Josefsson S, Chow WH, et al. The risk of stomach cancer in patients with gastric or duodenal ulcer disease. N Engl J Med 1996; 335(4): 242-9.

Kuipers EJ, Thijs JC, Festen HP. The prevalence of Helicobacter pylori in peptic ulcer disease. Aliment Pharmacol Ther 1995; 9(Suppl 2): 59-69.

Castro-Fernandez M, Sanchez-Munoz D, Garcia- Diaz E, Miralles-Sanchiz J, Vargas-Romero J. Diagnosis of Helicobacter pylori infection in patients with bleeding ulcer disease: rapid urease test and histology. Rev Esp Enferm Dig 2004; 96(6): 395-8.

Gisbert JP, Boixeda D, Aller R, de la Serna C, Sanz E, de Argila CM, et al. [Helicobacter pylori and digestive hemorrhage due to duodenal ulcer: the prevalence of the infection, the efficacy of 3 triple therapies and the role of eradication in preventing a hemorrhagic recurrence]. Med Clin (Barc) 1999; 112(5): 161-5.

Kuipers EJ. Helicobacter pylori and the risk and management of associated diseases: gastritis, ulcer disease, atrophic gastritis and gastric cancer. Aliment Pharmacol Ther 1997; 11(Suppl 1): 71-88.

Kashiwagi H. Ulcers and gastritis. Endoscopy 2003; 35(1): 9-14.

Malfertheiner P, Megraud F, O'Morain C, Bazzoli F, El-Omar E, Graham D, et al. Current concepts in the management of Helicobacter pylori infection: the Maastricht III Consensus Report. Gut 2007; 56(6): 772-81.

Suerbaum S, Michetti P. Helicobacter pylori infection. N Engl J Med 2002; 347(15): 1175-86.

Bytzer P, O'Morain C. Treatment of Helicobacter pylori. Helicobacter 2005; 10(Suppl 1): 40-6.

Egan BJ, O'Connor HJ, O'Morain CA. What is new in the Management of Helicobacter pylori? Ir J Med Sci 2008; 177(3): 185-8.

Foroumadi A, Sedaghat S, Emami S, Yazdanian M, Moshafi MH, Safavi M, et al. Synthesis and structure-activity relationship study of 2-substituted- 5-(5-nitro-2-thienyl)-1,3,4-thiadiazoles as anti-Helicobacter pylori agents. Letters in Drug Design and Discovery 2009; 6(6): 468-74.

Foroumadi A, Safavi M, Emami S, Siavoshi F, Najjari S, Safari F, et al. Structure-activity relationship study of a series of N-substituted piperazinyl-fluoroquinolones as anti-Helicobacter pylori agents. Med Chem 2008; 4(5): 498-502.

Foroumadi A, Rineh A, Emami S, Siavoshi F, Massarrat S, Safari F, et al. Synthesis and anti-Helicobacter pylori activity of 5-(nitroaryl)-1,3,4- thiadiazoles with certain sulfur containing alkyl side chain. Bioorg Med Chem Lett 2008; 18(11): 3315-20.

Foroumadi A, Sorkhi M, Moshafi MH, Safavi M, Rineh A, Siavoshi F, et al. 2-Substituted-5- nitroheterocycles: in vitro anti-Helicobacter pylori activity and structure-activity relationship study. Med Chem 2009; 5(6): 529-34.

Letafat B, Emami S, Aliabadi A, Mohammadhosseini N, Moshafi MH, Asadipour A, et al. Synthesis and in-vitro antibacterial activity of 5-substituted 1-methyl-4-nitro-1H-imidazoles. Arch Pharm (Weinheim) 2008; 341(8): 497-501.

Mohammadhosseini N, Letafat B, Siavoshi F, Emami S, Safari F, Shafiee A, et al. Synthesis and in vitro anti-Helicobacter pylori activity of 2- [(chlorobenzyl)thio]-5-(5-nitro-2-furyl)-1,3,4- thiadiazoles. Medicinal Chemistry Research 2008; 17(9): 578-86.

Mohammadhosseini N, Asadipour A, Letafat B, Vosooghi M, Siavoshi F, Shafiee A, et al. Synthesis and in vitro anti-Helicobacter pylori activity of 2- (substituted benzylthio)-5-(5-nitro-2-furyl)-1, 3, 4- thiadiazole derivatives. Turkish Journal of Chemistry 2009; 33(4): 471-8.

Moshafi MH, Yahya-Meymandi A, Esmaeil S, Ebrahimi S, Emami S, Nakhjiri M, et al. Synthesis and biological activity of 5-nitrofuran-containing (1, 3, 4-thiadiazol-2-yl) piperazine moieties as a new type of anti-Helicobacter pylori heterocycles. J Serb Chem Soc 2011; 76(2): 201-10.

Tafti AF, Akbarzadeh T, Saniee P. Synthesis and anti-Helicobacter pylori activity of (4-nitro-1- imidazolylmethyl)-1, 2, 4-triazoles, 1, 3, 4- thiadiazoles, and 1, 3, 4-oxadiazoles. Turkish Journal of Chemistry 2011; 35(2): 307-16.

Arzani M. Tebb-e-Akbari. Tehran, Iran: Research Institute for Islamic and Complementary Medicine; 2005. p. 636-7, 640. [In Persian].

Chashti MA. Romuz-e-Azam. Tehran, Iran: Research Institute for Islamic and Complementary Medicine; 2008. p. 396. [In Persian].

Kuipers EJ, Klinkenberg-Knol EC, Vandenbroucke-Grauls CM, Appelmelk BJ, Schenk BE, Meuwissen SG. Role of Helicobacter pylori in the pathogenesis of atrophic gastritis. Scand J Gastroenterol Suppl 1997; 223: 28-34.

Kuipers EJ, Appelmelk BJ. Helicobacter pylori and atrophic gastritis. Biomed Pharmacother 1997; 51(4): 150-5.

Chan FK, Leung WK. Peptic-ulcer disease. Lancet 2002; 360(9337): 933-41.

Dimaline R, Varro A. Attack and defence in the gastric epithelium - a delicate balance. Exp Physiol 2007; 92(4): 591-601.

Wallace JL. Prostaglandins, NSAIDs, and cytoprotection. Gastroenterol Clin North Am 1992; 21(3): 631-41.

Tulassay Z, Herszenyi L. Gastric mucosal defense and cytoprotection. Best Pract Res Clin Gastroenterol 2010; 24(2): 99-108.

Peskar BM, Maricic N. Role of prostaglandins in gastroprotection. Dig Dis Sci 1998; 43(9 Suppl): 23S-9S.

Cave DR. Transmission and epidemiology of Helicobacter pylori. Am J Med 1996; 100(5A): 12S-7S.

Ge Z, Taylor DE. Contributions of genome sequencing to understanding the biology of Helicobacter pylori. Annu Rev Microbiol 1999; 53: 353-87.

Amieva MR, Salama NR, Tompkins LS, Falkow S. Helicobacter pylori enter and survive within multivesicular vacuoles of epithelial cells. Cell Microbiol 2002; 4(10): 677-90.

Kwok T, Backert S, Schwarz H, Berger J, Meyer TF. Specific entry of Helicobacter pylori into cultured gastric epithelial cells via a zipper-like mechanism. Infect Immun 2002; 70(4): 2108-20.

McGowan CC, Cover TL, Blaser MJ. Helicobacter pylori and gastric acid: biological and therapeutic implications. Gastroenterology 1996; 110(3): 926-38.

El-Omar E, Penman I, Dorrian CA, Ardill JE, McColl KE. Eradicating Helicobacter pylori infection lowers gastrin mediated acid secretion by two thirds in patients with duodenal ulcer. Gut 1993; 34(8): 1060-5.

El-Omar EM, Penman ID, Ardill JE, Chittajallu RS, Howie C, McColl KE. Helicobacter pylori infection and abnormalities of acid secretion in patients with duodenal ulcer disease. Gastroenterology 1995; 109(3): 681-91.

McColl KE, El-Omar E, Gillen D. Interactions between H. pylori infection, gastric acid secretion and anti-secretory therapy. Br Med Bull 1998; 54(1): 121-38.

Chatterjee A, Chatterjee S, Bandyopadhyay SK. H. pylori-induced gastric ulcer: pathophysiology and herbal remedy. Int J Biol Med Res 2012; 3(1): 1461-5.

Tummuru MK, Sharma SA, Blaser MJ. Helicobacter pylori picB, a homologue of the Bordetella pertussis toxin secretion protein, is required for induction of IL-8 in gastric epithelial cells. Mol Microbiol 1995; 18(5): 867-76.

Kushima H, Hiruma-Lima CA, Santos MA, Viana E, Coelho-Ferreira M, Brito AR. Gastroprotective activity of Pradosia huberi on experimentally induced gastric lesions in rodents: role of endogenous sulphydryls and nitric oxide. J Ethnopharmacol 2005; 101(1-3): 61-7.

Chang CW, Chang WL, Chang ST. Influence of pH on bioactivity of cinnamon oil against Legionella pneumophila and its disinfection efficacy in hot springs. Water Res 2008; 42(20): 5022-30.

Dehghan Noudeh G, Sharififa F, Dehghan Noodeh A, Moshaf MH, Ahmadi Afzadi M, Behrava E, et al. Antitumor and antibacterial activity of four fractions from Heracleum persicum Desf. and Cinnamomum zeylanicum Blume. Journal of Medicinal Plants Research 2010; 4(21): 2176-80.

Matan N, Rimkeeree H, Mawson AJ, Chompreeda P, Haruthaithanasan V, Parker M. Antimicrobial activity of cinnamon and clove oils under modified atmosphere conditions. Int J Food Microbiol 2006; 107(2): 180-5.

Sanchis V, Ramos A, Marin S, Egido J. Inhibitory effect of cinnamon, clove, lemongrass, oregano and palmarose essential oils on growth and fumonisin B1 production by Fusarium proliferatum in maize grain. International Journal of Food Microbiology 2003; 89(2-3): 145-54.

Ali S, Khan A, Ahmed I, Musaddiq M, Ahmed K, Polasa H, et al. Antimicrobial activities of Eugenol and Cinnamaldehyde against the human gastric pathogen Helicobacter pylori. Ann Clin Microbiol Antimicrob 2005; 4: 20.

Nabati F, Mojab F, Habibi-Rezaei M, Bagherzadeh K, Amanlou M, Yousefi B. Large scale screening of commonly used Iranian traditional medicinal plants against urease activity. Daru 2012; 20(1): 72.

Tabak M, Armon R, Neeman I. Cinnamon extracts' inhibitory effect on Helicobacter pylori. J Ethnopharmacol 1999; 67(3): 269-77.

Hosseininejad Z, Darvish Moghadam S, Ebrahimi F, Abdollahi M, Zahedi MJ, Nazari M, et al. In vitro screening of selected Iranian medicinal plants against Helicobacter pylori. Int J Green Pharm

; 5: 282-5.

Razi MZ. Al-Havi. Tehran, Iran: Academy of Medical Sciences Islamic Republic of Iran; 2005. p. 227. [In Persian].

Al-Mofleh IA, Alhaider AA, Mossa JS, Al- Sohaibani MO, Rafatullah S, Qureshi S. Protection of gastric mucosal damage by Coriandrum sativum L. pretreatment in Wistar albino rats. Environ Toxicol Pharmacol 2006; 22(1): 64-9.

Zaidi SF, Muhammad JS, Shahryar S, Usmanghani K, Gilani AH, Jafri W, et al. Anti-inflammatory and cytoprotective effects of selected Pakistani medicinal plants in Helicobacter pylori- infected gastric epithelial cells. J Ethnopharmacol

Graziani G, D'Argenio G, Tuccillo C, Loguercio C, Ritieni A, Morisco F, et al. Apple polyphenol extracts prevent damage to human gastric epithelial cells in vitro and to rat gastric mucosa in vivo. Gut 2005; 54(2): 193-200.

Eberhardt MV, Lee CY, Liu RH. Antioxidant activity of fresh apples. Nature 2000; 405(6789): 903-4.

Carrasco-Pozo C, Speisky H, Brunser O, Pastene E, Gotteland M. Apple peel polyphenols protect against gastrointestinal mucosa alterations induced by indomethacin in rats. J Agric Food Chem 2011; 59(12): 6459-66.

D'Argenio G, Mazzone G, Tuccillo C, Grandone I, Gravina AG, Graziani G, et al. Apple polyphenol extracts prevent aspirin-induced damage to the rat gastric mucosa. Br J Nutr 2008; 100(6): 1228-36.

Pastene E, Speisky H, García A, Moreno J, Troncoso M, Figueroa G. In vitro and in vivo effects of apple peel polyphenols against Helicobacter pylori. J Agric Food Chem 2010; 58(12): 7172-9.

Aghili MH. Makhzan Al-Adviah. Tehran, Iran: Research Institute for Islamic and Complementary Medicine; 2008. p. 239. [In Persian].

Chawla YK, Dubey P, Singh R, Nundy S, Tandon BN. Treatment of dyspepsia with Amalaki (Emblica officinalis Linn.)--an Ayurvedic drug. Indian J Med Res 1982; 76(Suppl): 95-8.

Mehrotra S, Jamwal R, Shyam R, Meena DK, Mishra K, Patra R, et al. Anti-Helicobacter pylori and antioxidant properties of Emblica officinalis pulp extract: A potential source fortherapeutic use against gastric ulcer. Journal of Medicinal Plants Research 2011; 5(12): 2577-83.

Al-Rehaily AJ, Al-Howiriny TA, Al-Sohaibani MO, Rafatullah S. Gastroprotective effects of 'Amla' Emblica officinalis on in vivo test models in rats. Phytomedicine 2002; 9(6): 515-22.

Bandyopadhyay SK, Pakrashi SC, Pakrashi A. The role of antioxidant activity of Phyllanthus emblica fruits on prevention from indomethacin induced gastric ulcer. J Ethnopharmacol 2000; 70(2): 171-6.

Akhvaini Bokharaee AR. Hedayat Almotoalemin fi Al-Teb. Mashhad, Iran: Ferdowsi University of Mashhad Publication; 1965. p. 252-5. [In Persian].

Al-Said MS, Ageel AM, Parmar NS, Tariq M. Evaluation of mastic, a crude drug obtained from Pistacia lentiscus for gastric and duodenal anti- ulcer activity. J Ethnopharmacol 1986; 15(3): 271-8.

Huwez FU, Thirlwell D, Cockayne A, Ala'Aldeen DA. Mastic gum kills Helicobacter pylori. N Engl J Med 1998; 339(26): 1946.

Marone P, Bono L, Leone E, Bona S, Carretto E, Perversi L. Bactericidal activity of Pistacia lentiscus mastic gum against Helicobacter pylori. J Chemother 2001; 13(6): 611-4.

Paraschos S, Magiatis P, Mitakou S, Petraki K, Kalliaropoulos A, Maragkoudakis P, et al. In vitro and in vivo activities of Chios mastic gum extracts and constituents against Helicobacter pylori. Antimicrob Agents Chemother 2007; 51(2): 551-9.

Zargari A. Medicinal plants. Tehran, Iran: Tehran University Press; 1981. p. 218-20. [In Persian].

Karimi G, Hosseinzadeh H, Ettehad N. Evaluation of the gastric antiulcerogenic effects of Portulaca oleracea L. extracts in mice. Phytother Res 2004; 18(6): 484-7.

Borrelli F, Izzo AA. The plant kingdom as a source of anti-ulcer remedies. Phytother Res 2000; 14(8): 581-91.

Asuzu I, Onu OU. Anti-Ulcer activity of the ethanolic extract of Combretum dolichopetalum root. Pharmaceutical Biology 1990; 28(1): 27-32.

Jorjani SE. Al-Khafieh Al-Alaeieh. Trans. Velayati AA, Najmabadi M. Tehran, Iran: Ministry of Health and Medical Education; 1998. p. 178. [In Persian].

Shirazi MT. Tashil-al-Alaj. Qom, Iran: Jalaledin Publication; 2008. p. 59. [In Persian].

Duman AD, Ozgen M, Dayisoylu KS, Erbil N, Durgac C. Antimicrobial Activity of Six Pomegranate (Punica granatum L.) Varieties and Their Relation to Some of Their Pomological and Phytonutrient Characteristics. Molecules 2009; 14(5): 1808-17.

Tayel AA, El-Tras WF. Anticandidal activity of pomegranate peel extract aerosol as an applicable sanitizing method. Mycoses 2010; 53(2): 117-22.

Voravuthikunchai SP, Limsuwan S, Mitchell H. Effects of punica granatum pericarps and quercus infectoria nutgalls on cell surface hydrophobicity and cell survival of Helicobacter pylori. Journal of Health Science 2006; 52(2): 154-9.

Rahimi H, Arastoo M, Shiri M. Punica granatum is more effective to prevent gastric disorders induced by Helicobacter pylori or any other stimulator in humans. Asian Journal of Plant Sciences 2011; 10(7): 380-2.

Alkofahi A, Atta AH. Pharmacological screening of the anti-ulcerogenic effects of some Jordanian medicinal plants in rats. J Ethnopharmacol 1999; 67(3): 341-5.

Hajimahmoodi M, Shams-Ardakani M, Saniee P, Siavoshi F, Mehrabani M, Hosseinzadeh H, et al. In vitro antibacterial activity of some Iranian medicinal plant extracts against Helicobacter pylori. Nat Prod Res 2011; 25(11): 1059-66.

Nakhaei Moghaddam M. In vitro inhibition of Helicobacter pylori by some spices and medicinal plants used in Iran. Global Journal of Pharmacology 2011; 5(3): 176-80.

Qarshi A. Almojez fi Al-Teb. Tehran, Iran: Research Institute for Islamic and Complementary

Bag A, Bhattacharyya SK, Chattopadhyay RR.

The development of Terminalia chebula Retz. (Combretaceae) in clinical research. Asian Pac J Trop Biomed 2013; 3(3): 244-52.

Mishra V, Agrawal M, Onasanwo SA, Madhur G, Rastogi P, Pandey HP, et al. Anti-secretory and cyto-protective effects of chebulinic acid isolated from the fruits of Terminalia chebula on gastric ulcers. Phytomedicine 2013; 20(6): 506-11.

Malekzadeh F, Ehsanifar H, Shahamat M, Levin M, Colwell RR. Antibacterial activity of black myrobalan (Terminalia chebula Retz) against Helicobacter pylori. Int J Antimicrob Agents 2001;

(1): 85-8.

Hamilton-Miller JM. Antimicrobial properties of tea (Camellia sinensis L.). Antimicrob Agents Chemother 1995; 39(11): 2375-7.

Toda M, Okubo S, Hara Y, Shimamura T. [Antibacterial and bactericidal activities of tea extracts and catechins against methicillin resistant Staphylococcus aureus]. Nihon Saikingaku Zasshi 1991; 46(5): 839-45.

Diker KS, Hascelik G. The bactericidal activity of tea against Helicobacter pylori. Letters in Applied Microbiology 1994; 19(5): 299-300.

Setiawan VW, Zhang ZF, Yu GP, Lu QY, Li YL, Lu ML, et al. Protective effect of green tea on the risks of chronic gastritis and stomach cancer. Int J Cancer 2001; 92(4): 600-4.

Hassani AR, Ordouzadeh N, Ghaemi A, Amirmozafari N, Hamdi K, Nazari R. In vitro inhibition of Helicobacter pylori urease with non and semi fermented Camellia sinensis. Indian J Med Microbiol 2009; 27(1): 30-4.

Shahani S, Monsef-Esfahani HR, Saeidnia S, Saniee P, Siavoshi F, Foroumadi A, et al. Anti- Helicobacter pylori activity of the methanolic extract of Geum iranicum and its main compounds. Z Naturforsch C 2012; 67(3-4): 172-80.

Abutorabi H. Ethnobotanical and phytochemical study on the plants of Rouin region [Thesis]. Tehran, Iran: School of Pharmacy, Tehran University of Medical Sciences; 2001. [In Persian].

Sayyah M, Boostani H, Malayeri A, Siahpoosh A. Efficacy of hydroalcoholic extract of Rheum ribes L. in treatment of Obsessive compulsive disorder: A double blind clinical trial. J Pharm Biomed Sci 2011; 1(3): 57-61.

Oktay M, Yildirim A, Bilaloglu V, Gülçin I. Antioxidant activity of different parts of isgin (Rheum ribes L.). Asian Journal of Chemistry 2007; 19(4): 3047-55.

Sindhu RK, Kumar P, Kumar J, Kumar A, Arora S. investigations into the antiulcer activity of rheum ribes Linn leaves extracts. International Journal of Pharmacy and Pharmaceutical Sciences

; 2(Suppl 4): 90-3.

Soltanipoor MA. Investigation on relationship between ecological factors and natural distribution and density of Salvia mirzayanii Rech. & Esfand. medicinal species in Hormozgan province. J Med Plants 2007; 23(2): 218-25. [In Persian].

Moshafi MH, Mehrabani M, Zolhasab H. Antibacterial activity studies of Salvia Mirzayanii and Salvia Atropatana against six standard gram- positive and gram-negative bacteria. J Kerman Univ Med Sci 2004; 11(2): 109-18. [In Persian].

Moein MR, Moein S, Ahmadizadeh S. Radical scavenging and reducing power of Salvia mirzayanii subfractions. Molecules 2008; 13(11): 2804-13.

Atapour M, Zahedi M, Mehrabani M, Safavi M, Keyvanfard V, Foroughi A, et al. In vitro susceptibility of the Gram-negative bacterium Helicobacter pylori to extracts of Iranian medicinal plants. Pharmaceutical Biology 2009; 47(1): 77-80.

Shokrzadeh M, Saravi SS. The chemistry, pharmacology and clinical properties of Sambucus ebulus: A review. J Med Plant Res 2010; 4(2): 95-103.

Yesilada E, Gurbuz I, Shibata H. Screening of Turkish anti-ulcerogenic folk remedies for anti- Helicobacter pylori activity. J Ethnopharmacol 1999; 66(3): 289-93.

Ghasemi Pirbalouti A, Koohpyeh A. Wound Healing Activity of Extracts of Malva sylvestris and Stachys lavandulifolia. International Journal of Biology 2011; 3(1): 174-9.

Hajhashemi V, Ghannadi A, Sedighifar S. Analgesic and anti-inflammatory properties of the hydroalcoholic, polyphenolic and boiled extracts of Stachys lavandulifolia. Res Pharm Sci 2006; 1(2): 92-8.

Khanavi M, Sharifzadeh M, Hadjiakhoondi A, Shafiee A. Phytochemical investigation and anti- inflammatory activity of aerial parts of Stachys byzanthina C. Koch. Journal of Ethnopharmacology

; 97(3): 463-8.

Maleki N, Garjani A, Nazemiyeh H, Nilfouroushan N, Eftekhar Sadat AT, Allameh Z, et al. Potent anti-inflammatory activities of hydroalcoholic extract from aerial parts of Stachys inflata on rats. J Ethnopharmacol 2001; 75(2-3): 213-8.

Skaltsa HD, Demetzos C, Lazari D, Sokovic M. Essential oil analysis and antimicrobial activity of eight Stachys species from Greece. Phytochemistry 2003; 64(3): 743-52.

Nabavizadeh F, Alizadeh AM, Adeli S, Golestan M, Moloudian H, Kamalinejad M. Gastroprotective effects of Stachys Lavandulifolia extract on experimental gastric ulcer. African J Pharm Pharmacol 2011; 5(2): 155-9.

Kartsev V, Stepanichenko NN, Auelbekov SA. Chemical composition and pharmacological properties of plants of the genusStachys. Chemistry of Natural Compounds 1994; 30(6): 645-54.

Skaltsa HD, Lazari DM, Chinou IB, Loukis AE. Composition and antibacterial activity of the essential oils of Stachys candida and S. chrysantha from southern Greece. Planta Med 1999; 65(3):


Khanavi M, Safavi M, Siavoshi F, Fallah Tafti A, Hajimahmoodi M, Hadjiakhoondi A, et al. Evaluation of anti-helicobacter pylori activity of methanol extracts of some species of stachys and melia. J Med Plants 2008; 4(28): 74-80. [In Persian].

Rasooli I, Fakoor MH, Yadegarinia D, Gachkar L, Allameh A, Rezaei MB. Antimycotoxigenic characteristics of Rosmarinus officinalis and Trachyspermum copticum L. essential oils. Int J Food Microbiol 2008; 122(1-2): 135-9.

Nariman F, Eftekhar F, Habibi Z, Falsafi T. Anti-Helicobacter pylori activities of six Iranian plants. Helicobacter 2004; 9(2): 146-51.

Nariman F, Eftekhar F, Habibi Z, Massarrat S, Malekzadeh R. Antibacterial activity of twenty Iranian plant extracts against clinical Isolates of Helicobacter pylori. Iran J Basic Med Sci 2009;12(2): 105-11.

Sharififar F, Moshafi MH, Mansouri SH, Khodashenas M, Khoshnoodi M. In vitro evaluation of antibacterial and antioxidant activities of the essential oil and methanol extract of endemic Zataria multiflora Boiss. Food Control 2007; 18(7): 800-5.

Abdollahy F, Abdollahy H, Shabankhani, B, Azadbakht M. Effect of essential oils of Artemisia aucheri Boiss. Zataria multiflora Boiss, and Myrtus communis L. on Trichomonas vaginalis. Iran J Pharm Res 2004; 3(Suppl 2): 35.

Fazeli MR, Amin G, Ahmadian Attari MM, Ashtiani H, Jamalifar H, Samadi N. Antimicrobial activities of Iranian sumac and avishan-e shirazi (Zataria multiflora) against some food-borne bacteria. Food Control 2007; 18(6): 646-9.

Khosravi AR, Eslami AR, Shokri H, Kashanian M. Zataria multiflora cream for the treatment of acute vaginal candidiasis. Int J Gynaecol Obstet 2008; 101(2): 201-2.

Ravanshad Sh, Basiri E, Dastgheib B. Antimicrobial Activity of Different Concentrations of Essential Oil of Zataria Multiflora on Enterococcus Faecalis. Shiraz Univ. Dent. J 2007;8(1): 28-36.

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