A new strategy for treatment of chronic wounds according to Persian medicine: An evidence- based review

  • laila Shirbeigi Department of Persian Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran
  • soodeh karami Department of Persian Pharmacy, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran
  • Mina Mohebbi Department of Persian Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran
  • Fatemeh Nejatbakhsh Department of Persian Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran
  • Roja Rahimi Department of Persian Pharmacy, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran
Keywords: Persian medicine, chronic wound, medicinal plant, nutrition, homeostasis


Introduction: Chronic wounds reduce patient's quality of life by complications such as pain, secretions, and reduction of movement and impose large costs to health system. Thus, looking for treatment methods with higher success and less complications seems to be necessary. In Persian medicine, a variety of specific nutrients and medicinal plants have been recommended for chronic wounds. The aim of present study is to scientifically evaluate the nutrients and medicinal plants claimed to be effective for chronic wounds in Persian medicine. Material and method: Nutrients and medicinal plants recommended for chronic wounds in Persian medicine have been extracted from corresponding literatures. The obtained items were individually searched in electronic databases to obtain any in vitro, animal, or clinical evidence of their efficacy and possible underlying mechanisms. Results: The treatment of chronic wounds in Persian medicine consists of three steps .At first step some special foods like egg yolk and fig with special characteristics such as hematopoietic effect and antimicrobial activity are recommended. Administration of natural remedies in order to reduce internal inflammation and improve wound healing process such as Crocus sativus and Aloe vera consists of the second step. Finally the third step includes the use of topical natural agents that affects various stages of wound healing and can complete the wound healing process. Conclusion: According to Persian medicine, administration nutrients and medicinal plants is prior to topical treatments for management of chronic wounds. This strategy provides a new approach for management of chronic wounds and seems to be more useful than conventional treatment which is mostly focused on topical treatment


Powers JG, Higham C, Broussard K, Phillips TJ. Wound healing and treating wounds: Chronic wound care and management. J Am Acad Dermatol 2016;74:607-625.

Situm M, Kolic M, Redzepi G, Antolic S. Chronic wounds as a public health problem. Acta Med 2014;68:5-7.

Bellavia G, Fasanaro P, Melchionna R, Capogrossi MC, Napolitano M. Transcriptional control of skin reepithelialization. J Dermatol Sci 2014;73:3-9.

Shaw TJ, Martin P. Wound repair at a glance. J Cell SCI 2009;122:3209-3213.

Kondo T, Ishida Y. Molecular pathology of wound healing. Forensic Sci Int. 2010;203:93-98.

Li G, Gustafson-Brown C, Hanks SK, Nason K, Arbeit JM, Pogliano K, et al. c-Jun is essential for organization of the epidermal leading edge. Dev Cell 2003;4:865-877.

Atiyeh BS, Ioannovich J, Al-Amm CA, El-Musa KA. Management of acute and chronic open wounds: the importance of moist environment in optimal wound healing. Curr Pharm Biotechno. 2002;3:179-195.

Fonder MA, Lazarus GS, Cowan DA, Aronson-Cook B, Kohli AR, Mamelak AJ. Treating the chronic wound: A practical approach to the care of nonhealing wounds and wound care dressings. J Am Acad Dermatol 2008;58:185-206.

Guest JF, Gerrish A, Ayoub N, Vowden K, Vowden P. Clinical outcomes and cost-effectiveness of three alternative compression systems used in the management of venous leg ulcers. J Wound Care 2015;24:300.

Kermani N. Sharhe Asbaab-o-Alaamaat. Ehyae-Tebe-Tabiee Publications. Tehran 2008.

Azam Khan M. Exir-E-Azam. Tehran. Institute of Historical Studies, Islamic and Complementary Medicine. Tehran 2008.

Arzani M. Teb-E-Akbari. Ehyae-Tebe-Tabiee Publications. Tehran 2008.

Jorjani S. Al-Aghraz al- Tibbva val Mabahess al- Alaiia. Tehran University. Tehran 2006.

Avicenna H. Al-Qanun-Fi-Teb. Beirut: Al-Ama Lelmatbuaat Publications. 2005.

Kouvari M, Tyrovolas S, Panagiotakos DB. Red meat consumption and healthy ageing: A review. Maturitas. 2016;84:17-24.

Wright JA, Richards T, Srai SK. The role of iron in the skin and cutaneous wound healing. Front Pharmacol. 2014;5:156.

Tung YT, Tang TY, Chen HL, Yang SH, Chong KY, Cheng WT, et al. Lactoferrin protects against chemical-induced rat liver fibrosis by inhibiting stellate cell activation. J DAIRY SCI. 2014;97:3281-3291.

Hambraeus L. Animal- and plant-food-based diets and iron status: benefits and costs. P Nutr Soc. 1999;58:235-242.

Miller J, McNeal LS. Bioavailability of egg yolk iron measured by hemoglobin regeneration in anemic rats. The J Nutr. 1983;113:115-123.

Pepe G, Sommella E, Manfra M, De Nisco M, Tenore GC, Scopa A, et al. Evaluation of anti-inflammatory activity and fast UHPLC-DAD-IT-TOF profiling of polyphenolic compounds extracted from green lettuce (Lactuca sativa L.; var. Maravilla de Verano). Food Chem. 2015;167:153-361.

Ghimeray AK, Jung US, Lee HY, Kim YH, Ryu EK, Chang MS. In vitro antioxidant, collagenase inhibition, and in vivo anti-wrinkle effects of combined formulation containing Punica granatum, Ginkgo biloba, Ficus carica, and Morus alba fruits extract. Clin Cosmet Investig 2015;8:389-396.

Hooda J, Shah A, Zhang L. Heme, an essential nutrient from dietary proteins, critically impacts diverse physiological and pathological processes. Nutrients 2014;6:1080-1082.

Di Pierro G, O'Keeffe MB, Poyarkov A, Lomolino G, FitzGerald RJ. Antioxidant activity of bovine casein hydrolysates produced by Ficus carica L.-derived proteinase. Food Chem 2014;156:305-311.

Lee HY, Kim JH, Jeung HW, Lee CU, Kim DS, Li B, et al. Effects of Ficus carica paste on loperamide-induced constipation in rats. Food Chem Toxicol 2012;50:895-902.

Ali B, Mujeeb M, Aeri V, Mir SR, Faiyazuddin M, Shakeel F. Anti-inflammatory and antioxidant activity of Ficus carica Linn. leaves. Nat Prod Res 2012;460:25-26.

Viuda-Martos M, Sendra E, Sayas E, Perez-Alvarez JA, Fernandez-Lopez J. Fig (Ficus carica) Liquid Co-Products as New Potential Functional Ingredient: Physico-Chemical and In Vitro Antioxidant Properties. Nat Prod Commun 2015;10:1219-1223.

Abbasi AM, Shah MH, Li T, Fu X, Guo X, Liu RH. Ethnomedicinal values, phenolic contents and antioxidant properties of wild culinary vegetables. J Ethnopharmacol 2015;162:333-345.

Jing L, Zhang YM, Luo JG, Kong LY. Tirucallane-type triterpenoids from the fruit of Ficus carica and their cytotoxic activity. Chem Pharm Bull 2015;63:237-243.

Camero M, Marinaro M, Lovero A, Elia G, Losurdo M, Buonavoglia C, et al. In vitro antiviral activity of Ficus carica latex against caprine herpesviru. Nat Prod Res. 2014;28:2031-2035.

Allahyari S, Delazar A, Najafi M. Evaluation of general toxicity, anti-oxidant activity and effects of ficus carica leaves extract on ischemia/reperfusion injuries in isolated heart of rat. Adv Pharm Bull. 2014;4:577-582.

Badgujar SB, Patel VV, Bandivdekar AH, Mahajan RT. Traditional uses, phytochemistry and pharmacology of Ficus carica: a review. Pharm Biol 2014;52:1487.

Saoudi M, El Feki A. Protective Role of Ficus carica Stem Extract against Hepatic Oxidative Damage Induced by Methanol in Male Wistar Rats. Evid-Based Compl Alt 2012;2012:150458.

Mawa S, Husain K, Jantan I. Ficus carica L. (Moraceae): Phytochemistry, Traditional Uses and Biological Activities. Evid-Based Compl Alt. 2013;2013:974256.

Tian J, Zhang Y, Yang X, Rui K, Tang X, Ma J, et al. Ficus carica polysaccharides promote the maturation and function of dendritic cells. Int J Mol Sci 2014;15:12469-12479.

Hayouni EA, Miled K, Boubaker S, Bellasfar Z, Abedrabba M, Iwaski H. Hydroalcoholic extract based-ointment from Punica granatum L. peels with enhanced in vivo healing potential on dermal wounds. Phytomedicine : Phytomedicine 2011;18:976-984.

Mo J, Panichayupakaranant P, Kaewnopparat N, Nitiruangjaras A, Reanmongkol W. Wound healing activities of standardized pomegranate rind extract and its major antioxidant ellagic acid in rat dermal wounds. J Nat Med 2014;68:377-386.

Finegold SM, Summanen PH, Corbett K, Downes J, Henning SM, Li Z. Pomegranate extract exhibits in vitro activity against Clostridium difficile. Nutrition 2014;30:1210-1212.

Li G, Xu Y, Wang X, Zhang B, Shi C, Zhang W. Tannin-rich fraction from pomegranate rind damages membrane of Listeria monocytogenes. Foodborne Pathog Dis. 2014;11:313-319.

Haghayeghi K, Shetty K, Labbe R. Inhibition of foodborne pathogens by pomegranate juice. J Med Food 2013;16:467-470.

Israr F, Hassan F, Naqvi BS, Azhar I, Jabeen S, Hasan SM. Report: Studies on antibacterial activity of some traditional medicinal plants used in folk medicine. Pak J Pharm Sci 2012;25:669-674.

Su X, Howell AB, D'Souza DH. Antibacterial effects of plant-derived extracts on methicillin-resistant Staphylococcus aureus. Foodborne Pathog Dis 2012;9:573-578.

Turkyilmaz M, Tagi S, Dereli U, Ozkan M. Effects of various pressing programs and yields on the antioxidant activity, antimicrobial activity, phenolic content and colour of pomegranate juices. Food Chem 2013;138:1810-1818.

Fawole OA, Makunga NP, Opara UL. Antibacterial, antioxidant and tyrosinase-inhibition activities of pomegranate fruit peel methanolic extract. BMC Complem Altern M 2012;12:200.

Nayak SB, Rodrigues V, Maharaj S, Bhogadi VS. Wound healing activity of the fruit skin of Punica granatum. J Med Food. 2013;16:857-861.

Jadoon S, Karim S, Bin Asad MH, Akram MR, Khan AK, Malik A, et al. Anti-Aging Potential of Phytoextract Loaded-Pharmaceutical Creams for Human Skin Cell Longetivity. Oxid Med Cell Longev. 2015;2015:709628.

Amal B, Veena B, Jayachandran VP, Shilpa J. Preparation and characterisation of Punica granatum pericarp aqueous extract loaded chitosan-collagen-starch membrane: role in wound healing process. J Mater Sci-Mater M. 2015;26:181.

da Silva JK, Cazarin CB, Correa LC, Batista AG, Furlan CP, Biasoto AC, et al. Bioactive compounds of juices from two Brazilian grape cultivars. J Sci Food Agr. 201;16:23-27.

Perez C, Ruiz del Castillo ML, Gil C, Blanch GP, Flores G. Supercritical fluid extraction of grape seeds: extract chemical composition, antioxidant activity and inhibition of nitrite production in LPS-stimulated Raw 264.7 cells. Food Funct 2015;6:2607-2613.

Nile SH, Park SW. Determination of polyphenols and antioxidant activity of Vitis labrusca cv. baile berries. Indian J Exp Biol 2015;53:671-675.

Campanholo VM, Silva RM, Silva TD, Neto RA, Paiotti AP, Ribeiro DA, et al. Oral concentrated grape juice suppresses expression of NF-kappa B, TNF-alpha and iNOS in experimentally induced colorectal carcinogenesis in Wistar rats. Asian Pac J Cancer P 2015;16:947-952.

Burri BJ, La Frano MR, Zhu C. Absorption, metabolism, and functions of beta-cryptoxanthin. Nutr Rev 2016;74:69-82.

Attard E, Martinoli MG. Cucurbitacin E, An Experimental Lead Triterpenoid with Anticancer, Immunomodulatory and Novel Effects Against Degenerative Diseases. A Mini-Review. Curr Top Med Chem 2015;15:1708-1713.

Bardaa S, Moalla D, Ben Khedir S, Rebai T, Sahnoun Z. The evaluation of the healing proprieties of pumpkin and linseed oils on deep second-degree burns in rats. Pharm Biol 2015:1-7.

Xue Z, Gao J, Zhang Z, Yu W, Wang H, Kou X. Antihyperlipidemic and antitumor effects of chickpea albumin hydrolysate. Plant Food Hum Nutr 2012;67:393-400.

Ferrari CK, Percario S, Silva JC, da Silva Torres EA. An apple plus a nut a day keepS the doctors away: antioxidant capacity of foods and their health benefits. Curr Pharm Design 2015;22:189-190.

Aires A, Marques E, Carvalho R, Rosa EA, Saavedra MJ. Evaluation of biological value and appraisal of polyphenols and glucosinolates from organic baby-leaf salads as antioxidants and antimicrobials against important human pathogenic bacteria. Molecules 2013;18:4651-4668.

Gridling M, Popescu R, Kopp B, Wagner KH, Krenn L, Krupitza G. Anti-leukaemic effects of two extract types of Lactuca sativa correlate with the activation of Chk2, induction of p21, downregulation of cyclin D1 and acetylation of alpha-tubulin. Oncol Rep 2010;23:1145-1151.

Zhang HL, Dai LH, Wu YH, Yu XP, Zhang YY, Guan RF, et al. Evaluation of hepatocyteprotective and anti-hepatitis B virus properties of Cichoric acid from Cichorium intybus leaves in cell culture. Biol Pharm Bull 2014;37:1214-1220.

Esmaeilbeig M, Kouhpayeh SA, Amirghofran Z. An Investigation of the Growth Inhibitory Capacity of Several Medicinal Plants From Iran on Tumor Cell Lines. Iran J Cancer Prev 2015;8:e4032.

Zhu D, Wang Y, Du Q, Liu Z, Liu X. Cichoric Acid Reverses Insulin Resistance and Suppresses Inflammatory Responses in the Glucosamine-Induced HepG2 Cells. J Agric Food Chem 2015;63:10903-10913.

Lee NY, Chung KS, Jin JS, Bang KS, Eom YJ, Hong CH, et al. Effect of Chicoric Acid on Mast Cell-Mediated Allergic Inflammation in Vitro and in Vivo. J Nat Prod 2015;78:2956-2962.

Abbas ZK, Saggu S, Sakeran MI, Zidan N, Rehman H, Ansari AA. Phytochemical, antioxidant and mineral composition of hydroalcoholic extract of chicory (Cichorium intybus L.) leaves. Saudi J Biol Sci 2015;22:322-326.

El-Sayed YS, Lebda MA, Hassinin M, Neoman SA. Chicory (Cichorium intybus L.) root extract regulates the oxidative status and antioxidant gene transcripts in CCl4-induced hepatotoxicity. PloS one. 2015;10:e0121549.

Rizvi W, Fayazuddin M, Shariq S, Singh O, Moin S, Akhtar K, et al. Anti-inflammatory activity of roots of Cichorium intybus due to its inhibitory effect on various cytokines and antioxidant activity. Ancient science of life 2014;34:44-49.

Jyothilakshmi V, Thellamudhu G, Chinta R, Alok K, Anil K, Debadatta N, et al. Beneficial antioxidative effect of the homeopathic preparation of Berberis vulgaris in alleviating oxidative stress in experimental urolithiasis. Forsch Komplementmed (2006). 2014;21:7-12.

Snowden R, Harrington H, Morrill K, Jeane L, Garrity J, Orian M, et al. A comparison of the anti-Staphylococcus aureus activity of extracts from commonly used medicinal plants. J Altern Complem Med 2014;20:375-382.

Zarei A, Changizi-Ashtiyani S, Taheri S, Ramezani M. A quick overview on some aspects of endocrinological and therapeutic effects of Berberis vulgaris L. Avicenna J Phytomed. 2015;5:485-497.

Hoshyar R, Mahboob Z, Zarban A. The antioxidant and chemical properties of Berberis vulgaris and its cytotoxic effect on human breast carcinoma cells. Cytotechnology 2015.

Saedi TA, Ghafourian S, Jafarlou M, Sabariah MN, Ismail P, Eusni RM. berberis vulgaris fruit crude extract as a novel anti-leukaemic agent. J Biol Reg Homeos Ag. 2019;395:31-37.

Sengul M, Yildiz H, Gungor N, Cetin B, Eser Z, Ercisli S. Total phenolic content, antioxidant and antimicrobial activities of some medicinal plants. Pak J Pharm Sci 2009;22:102-106.

Loots DT, van der Westhuizen FH, Botes L. Aloe ferox leaf gel phytochemical content, antioxidant capacity, and possible health benefits. J Agr Food Chem. 2007;55:6891-6896.

Gülçın İ, Oktay M, Kıreçcı E, Küfrevıoǧlu Öİ. Screening of antioxidant and antimicrobial activities of anise (Pimpinella anisum L.) seed extracts. Food Chem 2003;83:371-382.

Lopes-Lutz D, Alviano DS, Alviano CS, Kolodziejczyk PP. Screening of chemical composition, antimicrobial and antioxidant activities of Artemisia essential oils. Phytochemistry 2008;69:1732-1738.

Craciunescu O, Constantin D, Gaspar A, Toma L, Utoiu E, Moldovan L. Evaluation of antioxidant and cytoprotective activities of Arnica montana L. and Artemisia absinthium L. ethanolic extracts. Chem Cent J 2012;6:97.

Shahidi Bonjar G, Aghighi S, Karimi Nik A. Antibacterial and antifungal survey in plants used in indigenous herbal-medicine of south east regions of Iran. J Biol Chem. 2004;4:405-412.

Kamaraj C, Rahuman AA, Siva C, Iyappan M, Kirthi AV. Evaluation of antibacterial activity of selected medicinal plant extracts from south India against human pathogens. Asian Pac J Trop Med. 2012;2:S296-S301.

Tril U, Fernández-López J, Álvarez JÁP, Viuda-Martos M. Chemical, physicochemical, technological, antibacterial and antioxidant properties of rich-fibre powder extract obtained from tamarind (Tamarindus indica L.) Ind Crop Prod 2014;55:155-162.

Doughari J. Antimicrobial activity of Tamarindus indica Linn. Trop J Pharm Res 2007;5:597-603.

Kathirvel A, Sujatha V. In vitro assessment of antioxidant and antibacterial properties of Terminalia chebula Retz. Leaves. Asian Pac J Trop Med 2012;2:S788-S795.

Ziad D, Elias A, Roula A-M. Antibacterial activity of Rheum rhaponticum, Olea europaea and Viola odorata on ESBL producing clinical isolates of Escherichia coli and Klebsiella pneumoniae. Int J Pharm Sci Res 2011;2:1669-1678.

Ebrahimzadeh MA, Nabavi SM, Nabavi SF, Bahramian F, Bekhradnia AR. Antioxidant and free radical scavenging activity of H. officinalis L. var. angustifolius, V. odorata, B. hyrcana and C. speciosum. Pak J Pharm Sci 2010;23:29-34.

Amir M, Khan A, Mujeeb M, Ahmad A, Usmani S, Akhtar M. Phytochemical analysis and in vitro antioxidant activity of Zingiber officinale. Biochem Soc Symp 2011;1:75-81.

Bellik Y. Total antioxidant activity and antimicrobial potency of the essential oil and oleoresin of Zingiber officinale Roscoe. Asian Pac J Trop Med 2014;4:40-44.

Memarpoor-Yazdi M, Mahaki H, Zare-Zardini H. Antioxidant activity of protein hydrolysates and purified peptides from Zizyphus jujuba fruits. J Funct Foods. 2013;5:62-70.

Zhang H, Jiang L, Ye S, Ye Y, Ren F. Systematic evaluation of antioxidant capacities of the ethanolic extract of different tissues of jujube (Ziziphus jujuba Mill.) from China. Food Chem Toxicol 2010;48:1461-1465.

Chithra P, Sajithlal G, Chandrakasan G. Influence of Aloe vera on the healing of dermal wounds in diabetic rats. J Ethnopharmacol 1998;59:195-201.

Kumar MS, Kirubanandan S, Sripriya R, Sehgal PK. Triphala promotes healing of infected full-thickness dermal wound. J Surg Res 2008;144:94-101.

Goyal R, Sharma PL, Singh M. Possible attenuation of nitric oxide expression in anti-inflammatory effect of Ziziphus jujuba in rat. J Nat Med. 2011;65:514-518.

Jia Y, Zhao G, Jia J. Preliminary evaluation: the effects of Aloe ferox Miller and Aloe arborescens Miller on wound healing. J Ethnopharmacol 2008;120:181-189.

Atiba A, Nishimura M, Kakinuma S, Hiraoka T, Goryo M, Shimada Y. Aloe vera oral administration accelerates acute radiation-delayed wound healing by stimulating transforming growth factor-β and fibroblast growth factor production. Am J Surg 2011;201:809-818.

Singh MP, Sharma CS. Wound healing activity of Terminalia chebula in experimentally induced diabetic rats. Int J Pharm 2009;1:1267-1270.

Aref HL, Salah K, Chaumont JP, Fekih A, Aouni M, Said K. In vitro antimicrobial activity of four Ficus carica latex fractions against resistant human pathogens (antimicrobial activity of Ficus carica latex). Pak J Pharm Sci 2010;23:53-58.

Iauk L, Ragusa S, Rapisarda A, Franco S, Nicolosi V. In vitro antimicrobial activity of Pistacia lentiscus L. extracts: preliminary report. J Chemotherapy. 1996;8:207-209.

Tohma HS, Gulçin I. Antioxidant and radical scavenging activity of aerial parts and roots of Turkish liquorice (Glycyrrhiza glabra L.). Int J Food Prop 2010;13:657-671.

Patil S, Patil M, Sapkale G. Antimicrobial activity of Glycyrrhiza glabra Linn. roots. Int J Chem Sci 2009;7:585-91.

Assimopoulou A, Sinakos Z, Papageorgiou V. Radical scavenging activity of Crocus sativus L. extract and its bioactive constituents. Phytother Res. 2005;19:997-1000.

Shahwar D, Raza MA, Bukhari S, Bukhari G. Ferric reducing antioxidant power of essential oils extracted from Eucalyptus and Curcuma species. Asian Pac J Trop Med 2012;2:S1633-S1636.

Shivalingu BR, Vivek HK, Nafeesa Z, Priya BS, Swamy SN. Comparative analysis of procoagulant and fibrinogenolytic activity of crude protease fractions of turmeric species. J Ethnopharmacol. 2015;172:261-4.

Suja KP, Jayalekshmy A , Arumughan C. Free radical scavenging behavior of antioxidant compounds of sesame (Sesamum indicum L.) in DPPH system). J Agr Food Chem. 2004;52:912-915.

Khorasani G, Jalal Hosseinimehr S, Zamani P, Ghasemi M, Ahmadi A. The effect of saffron (Crocus sativus) extract for healing of second-degree burn wounds in rats. Keio J Med 2008;57:190-195.

Kant V, Gopal A, Kumar D, Pathak NN, Ram M, Jangir BL. Curcumin-induced angiogenesis hastens wound healing in diabetic rats. J Surg Res. 2015;193:978-988.

Durgaprasad S, Reetesh R, Hareesh K, Rajput R. Effect of a topical curcumin preparation (BIOCURCUMAX) on burn wound healing in rats. J Pharmaceut Biomed 2011;8:20-26.

Li X, Nan K, Li L, Zhang Z, Chen H. In vivo evaluation of curcumin nanoformulation loaded methoxy poly(ethylene glycol)-graft-chitosan composite film for wound healing application. Carbohyd Polym 2012;88:84-90.

Tanideh N, Rokhsari P, Mehrabani D, Samani SM, Sarvestani FS, Ashraf MJ. The healing effect of licorice on Pseudomonas aeruginosa infected burn wounds in experimental rat model. World Journal of Plastic Surgery 2014;3(2):99.

Maameri Z, Beroual K, Djerrou Z, Habibatni S, Benlaksira B, Serakta M, et al. Preliminary study to assess cicatrizing activity of honey and Pistacia lentiscus fatty oil mixture on experimental burns in rabbits. J Appl Res Med Aromat Plants. 2012;2:476-480.

Djerrou J, Maameri Z, Hamdo-Pacha Y, Serakta M, Riachi F, Djaalab H, et al. Effect of virgin fatty oil of Pistacia lentiscus on experimental burn wound’s healing in rabbits. Afr J Tradit Complem 2010;7:13-15.

Shenoy RR, Sudheendra AT, Nayak PG, Paul P, Kutty NG, Rao CM. Normal and delayed wound healing is improved by sesamol, an active constituent of Sesamum indicum (L.) in albino rats. J Ethnopharmacol. 2011;133:608-12.

Kiran K, Asad M. Wound healing activity of Sesamum indicum L seed and oil in rats. Indian J Exp Biol. 2008;46:777.

Posnett J, Franks P. The burden of chronic wounds in the UK. Diabetic Med. 2008;14:S7-S85.

Leoni G, Neumann PA, Sumagin R, Denning TL, Nusrat A. Wound repair: role of immune-epithelial interactions. Mucosal Immunol 2015;8:959-968.

How to Cite
Shirbeigi laila, karami soodeh, Mohebbi M, Nejatbakhsh F, Rahimi R. A new strategy for treatment of chronic wounds according to Persian medicine: An evidence- based review. JTIM. 3(3):162-76.
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