Antioxidant Property of Majoon-e-Dabeed-ul-Ward: a Traditional Herbal Formulation in Persian Medicine
AbstractTraditional medicine is used for treating diseases in different countries and it is a way for promoting public health especially in under developing countries. Persian medicine has a long history and has been an inseparable part of the Iranian people's life and culture. There are many herbal formulations in Iran that prepared following Persian medicine methods and prescribed for different diseases. Majoon-e-Dabeed-ul-Ward is one of these products and to the best of our knowledge there is no documented study about the formulation used in Iran. In this study, Persian medicine manuscripts were explored for main ingredients of Majoon-e-Dabeed-ul-Ward as well as serious diseases in which this medication has been considered as a potential treatment. Additionally, the antioxidant effect of the commonly used formula in Iran was studied using DPPH method. There were different formulations with 16 or more constituents under the name of Dabeed-ul-Ward in Persian manuscripts; Rosa damascena was the main constituent of this herbal mixture. Majoon-e-Dabeed-ul-Ward has been prescribed for different purposes like liver disorders, pelvic inflammation, eczema, psoriasis, headache and vertigo. Commonly used Majoon-e-Dabeed-ul-Ward in Iran contains 16 plants in addition to sugar. Majoon-e-Dabeed-ul-Ward hydro- alcoholic extract possessed radical scavenging activity with IC50 value of 174 μg/mL.
Bozorgi M, Mirmasoumi M, Amin G. Determination of Scientific Name of Faranjmoshk: A Traditional Persian Medicinal Plant. Trad Integr Med 2017:2,74-77.
Naghibi F, Mosaddegh M, Mohammadi Motamed S, Ghor¬bani A. Labiatae family in folk medicine in Iran: From eth¬nobotany to pharmacology. Iran J Pharm Res 2005;4:63-79.
Rezaeizadeh H, Alizadeh M, Naseri M, Shams Ardakani MR. The traditional Iranian medicine point of view on health and disease. Iranian J Publ Health 2009;38:169-172.
Adhami HR, Mesgarpour B, Farsam H. Herbal Medicine in Iran. HerbalGram 2007;74:35-43.
Avicenna. Canon of Medicine. Soroosh Press. Tehran 1989; p 425.
Aghili Shirazi SMH. Qarabadin-e-Kabir. Islamic medicine and complementary medicine institute press. Tehran 2004; p 160.
Cheshti M. Exir aazam. 2nd ed. Iran Univer¬sity of Medical Sciences. Islamic medicine and comple-mentary medicine institute press. Tehran 2008; p 210.
Bozorgi M, Vazirian M. Antioxidant Activity of Lallemantia royleana (Benth.) Seed Extract. Trad Intrgr Med 2016:1,147-150.
Rahman R, Kausar F, Naaz F, Shamsi Y. Efficacy and Safety of Dabidulward for the Treatment of Pelvic inflammatory disease: A Placebo Controlled Randomised Clinical Trial. IJAHM 2014;4:1544-1556.
Shakya AK, Shukla S. Evaluation of Hepatoprotective Efficacy of Majoon-e-Dabeed-ul-ward Against Acetaminophen-Induced Liver Damage: A Unani Herbal Formulation Drug. Dev Res 2011;72:346–352.
Shakya AK, Sharma N, Saxena M, Shrivastava S, Shukla S. Evaluation of the antioxidant and hepatoprotective effect of Majoon-e-Dabeed-ul-ward against carbon tetrachloride induced liver injury. Exp Toxicol Pathol 2012;64:767–773.