Tehran University of Medical Sciences Traditional and Integrative Medicine 2476-5104 7 1 2022 03 09 1 12 EN Kamyar Khoshnevisan Medical Nanotechnology and Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran AND Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Hiva Alipanah Department of Physiology, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran Hadi Baharifar Department of Medical Nanotechnology, Applied Biophotonics Research Center, Science and Research Branch, Islamic Azad University, Tehran, 1477893855, Iran Negar Ranjbar Department of Medicine, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran Mahmoud Osanloo Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Fasa University of Medical Sciences, Fasa, Iran 2021 05 30 2021 07 16 Cancer is the second leading cause of death worldwide, and due to the emergence of resistance to synthetic drugs in different cancers, developing new green drugs have become crucial. In this study, chitosan nanoparticles containing Cinnamomum verum J.Presl essential oil and cinnamaldehyde (major ingredient) were first prepared. The obtained nanoparticles were then characterized using Dynamic Light Scattering (DLS), Transmission electron microscopy (TEM), and Attenuated Total Reflection-Fourier Transform InfraRed (ATR-FTIR). After that, anticancer effects of the as-prepared nanoparticles were investigated. IC50 values of chitosan nanoparticles containing the essential oil were observed at 79 and 112 µg/mL against A-375 and MDA-MB-468 cells, respectively. These values for chitosan nanoparticles containing cinnamaldehyde were obtained at 135 and 166 µg/mL. The results of the current study indicated that chitosan nanoparticles containing C. verum essential oil can inhibit the growth of human melanoma (A-375) and breast cancer (MDA-MB-468) cells. https://jtim.tums.ac.ir/index.php/jtim/article/view/435

Tehran University of Medical Sciences Traditional and Integrative Medicine 2476-5104 7 1 2022 03 14 124 134 EN Mustehasan Mustehasan Central Council for Research in Unani Medicine, Janakpuri New Delhi, 110058, India Misbahuddin Azhar Regional Research Institute of Unani Medicine, Shahjahan Manzil, Near AMU Riding Club, Aligarh, 202002, India Sofia Naushin Central Council for Research in Unani Medicine, Janakpuri New Delhi, 110058, India Mohd Urooj National Research Institute of Unani Medicine for Skin Disorders, Hyderabad, 500038, India Gulam Mohammed Husain National Research Institute of Unani Medicine for Skin Disorders, Hyderabad, 500038, India 2021 06 18 2021 09 17 The ultra-fine powder of Sang-e-Surma (Surma Stone), also known as Kohl, is used for various eye ailments either alone or in combination with other herbal or mineral ingredients. The earliest use of Surma is reported in Egypt about 3100 BC. Data from a number of studies conducted on Sang-e-Surma using modern analytical techniques have cleared the uncertainty that Surma stone is mainly composed of lead sulphide. Surma is reported to be used for impaired eye-sight, ophthalmia, cataract, itching, redness, irritation, watering of eyes, shedding of eyelashes and in the initial stage of cataract. The use of lead based Surma is discouraged owing to reports of lead toxicity though the sun glare protection and antimicrobial effects of Surma have been established. Reports on lead toxicity by the application of Surma in eyes are conflicting. Appropriately planned studies are warranted to elaborate the toxic effects of lead based Surma/kohl in terms of detoxification of Sang-e-Surma, preclinical toxicity and clinical trial. https://jtim.tums.ac.ir/index.php/jtim/article/view/460

Tehran University of Medical Sciences Traditional and Integrative Medicine 2476-5104 7 1 2022 03 09 13 19 EN Fahimeh Rashidi Maybodi Periodontics Department, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Farzane Vaziri Periodontics Department, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Solmaz Ghanbarnezhad Department of Materials Engineering, School of Materials Engineering, Tehran Branch, Islamic Azad University, Tehran, Iran Vahid Herandi Periodontics Department, Shahid Sadoughi University of Medical Sciences, Yazd, Iran 2021 04 17 2021 12 04 Many therapeutic properties have been reported for saffron (Crocus sativus L.), including anti-inflammatory effects due to its strong antioxidant properties and the ability to accumulate oxygen free radicals by components such as crocin and crocetin. The aim of this study was to evaluate the anti-inflammatory effect of saffron on the treatment of patients with periodontitis. 40 patients with moderate to severe generalized periodontitis were selected and divided randomly into the intervention and control groups. The intervention group was instructed to use a mouthwash containing aqueous saffron extract twice a day for 2 weeks; while the control group members were asked to apply chlorhexidine as the gold standard mouthwash. The participants’ gingival probing depth index, modified gingival index, and gingival bleeding index were measured before and one month after the intervention. The patients’ level of satisfaction on the taste of mouthwash was also measured. T-test and Mann-Whitney test were run for statistical analysis. A significant difference was observed in terms of the gingival indices before and four weeks after using both saffron and chlorhexidine mouthwashes (p value: 0.001). However, no statistically significant difference was found between two groups. Patients reported higher levels of taste satisfaction after using saffron aqueous extract mouthwash than the chlorhexidine mouthwash (p value: 0.021). Saffron mouthwash showed comparable therapeutic effect to the gold standard mouthwash, chlorhexidine, and may be helpful as an adjunct treatment for management of periodontitis. https://jtim.tums.ac.ir/index.php/jtim/article/view/389

Tehran University of Medical Sciences Traditional and Integrative Medicine 2476-5104 7 1 2022 03 14 135 149 Hoorieh Mohammadi Kenari Research Institute for Islamic and Complementary Medicine, School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran Gholamreza Kordafshari School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran Maryam Moghimi Masiha Teb Shomal Knowledge-Based Cooperation, Sari, Iran 2021 06 12 2021 08 02 Cupping has a long history in Iran which is one of the most widely used methods in prevention and treatment of diseases in Persian medicine. However, it still has many opponents in the Iranian conventional medical community. So, this systematic review study was conducted to survey the scientific and authoritative articles related to wet and dry cupping that have been done in Iran and the diseases for which Iranian researchers have suggested cupping. In general, the effect of wet and dry cupping on various kinds of pain (e.g. headache, musculoskeletal pain, postpartum pain, etc.), as well as the effect of wet cupping on hematological and biochemical factors of blood were among the most common studies. Also, persistence of therapeutic effects of wet and dry cupping on various diseases was satisfactory. The results of this study showed that wet and dry cupping, even alone, are effective in the treatment of many diseases, and if the objections to the use of these two treatments are reduced, more extensive and high-quality researches in this regard will be done. https://jtim.tums.ac.ir/index.php/jtim/article/view/451

Tehran University of Medical Sciences Traditional and Integrative Medicine 2476-5104 7 1 2022 03 09 20 39 EN Hossein Kerdarian Student Research Committee, Babol University of Medical Sciences, Babol, Iran Seyed Hassan ‎ Abedi Department of Internal Medicine, School of Medicine, Babol University of Medical Sciences, Babol, Iran Seyyed Ali Mozaffarpur Department of Persian Medicine, School of Persian Medicine, Babol University of Medical Sciences, Babol, Iran Hoda Shirafkan Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran Zahra Memariani Traditional Medicine and History of Medical Sciences Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran 2021 04 22 2021 07 05 Functional dyspepsia (FD) is a common gastroduodenal disorder that can be long-lasting. In the present study, we aimed to investigate the effect of herbal medicine, Ghors-e-Vard (Vard), on clinical symptoms in FD patients. Seventy adult FD patients according to the Rome IV criteria and without Helicobacter pylori infection were included. Participants were randomly allocated to either Vard or placebo group for 4 weeks of intervention. Treatments were given orally in a double-blind fashion (500 mg, three times a day, and half an hour after each meal). Patients were evaluated prior to and following 2, 4, and 8 weeks after the intervention, in terms of changes in the total score of gastrointestinal symptoms rating scale (GSRS), Depression Anxiety Stress Scales (DASS-21), scores of various components of the 36-item short-form health survey (SF-36), and any reported side effects. The differences of GSRS and DASS-21 total scores from baseline to the end of intervention were significantly larger in Vard group (P<0.001). Except for reflux, the other subtypes of FD symptoms were decreased with a significantly greater effect in Vard group (P < 0.05). Also, changes in the total score of SF-36 at 4 and 8 weeks after the intervention were significantly greater in Vard group (P<0.001). Except for the reflux, improvement of gastrointestinal symptoms, along with depression, stress, and anxiety, as well as the quality of life in Vard group, was significantly superior to the placebo group. These findings suggest that the Vard, as a complementary therapy, may have a promising effect on resolving the FD symptoms. https://jtim.tums.ac.ir/index.php/jtim/article/view/395

Tehran University of Medical Sciences Traditional and Integrative Medicine 2476-5104 7 1 2022 03 09 150 158 Ali Abdolahinia Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran AND Persian Medicine Network (PMN), Universal Scientific Education and Research Network (USERN), Tehran, Iran Mohsen Naseri Traditional Medicine Clinical Trial Research Center, Shahed University, Tehran, Iran Soodeh Tahmasbi Department of Orthodontics, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran Parisa Adimi Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran Makan Sadr Virology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran Ali Akbar Velayati Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran 2021 02 08 2021 11 09 Persian medicine introduces six essential principles to maintain health and improve the breathing of the patients with pulmonary diseases. Adherence to each of these principles plays an important role in having healthy lungs. The purpose of this study was to review the scientific evidence of the mentioned recommendations while discussing the Persian medicine recommendations. Accordingly, suggestions related to maintaining lung health were extracted from the main sources of Persian medicine. In addition, similar topics were searched in PubMed, Scopus, Google Scholar, Web of Science, and SID databases. Then, results were expressed separately in each aspect of the six essential principles. These recommendations which are the result of hundreds-of-years-experience of Iranian physicians could be useful; however, future experimental investigations are needed to approve their safety and efficacy along with the possible mechanisms of action. https://jtim.tums.ac.ir/index.php/jtim/article/view/311

Tehran University of Medical Sciences Traditional and Integrative Medicine 2476-5104 7 1 2022 03 09 40 51 Abbas Joushan Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran Sadegh Rajabi Traditional Medicine and Materia Medica Research Center (TMRC), Shahid Beheshti University of Medical Sciences, Tehran, Iran Khosrow Agin Pulmonologist and Pulmonary Critical Care, Shahid Beheshti University of Medical Sciences, Loghman Hakim General Teaching Hospital, Tehran, Iran Mohammad Hossein Ayati School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran Fatemeh Jafari Traditional Medicine and Materia Medica Research Center (TMRC), Shahid Beheshti University of Medical Sciences, Tehran, Iran Babak Daneshfard Chronic Respiratory Diseases Research Center, Natoinal Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran AND Persian Medicine Network (PMN), Universal Scientific Education and Research Network (USERN), Tehran, Iran Sayyed Shamsadin Athari Department of Immunology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran Zeinab Ghahremani Department of Psychiatric Nursing, School of Nursing and Midwifery, Zanjan University of Medical Sciences, Zanjan, Iran Rasool Choopani Traditional Medicine and Materia Medica Research Center (TMRC), Shahid Beheshti University of Medical Sciences, Tehran, Iran AND Department of Traditional Medicine, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran 2021 04 28 2021 07 14 As an inflammatory disease of the lung, asthma is characterized by bronchoconstriction, mucus hypersecretion, inflammatory mediator release, and eosinophil recruitment. Cupping therapy is an ancient method of treatment for a vast range of ailments. This study aimed to evaluate the anti-asthmatic effects of wet cupping therapy (WCT) in a mouse model. A total number of 35 Balb/c mice were randomly divided into five groups (n = 7): Negative and positive control groups were administered Phosphate Buffered Saline (PBS) and ovalbumin (OVA), respectively. The remaining three OVA-challenged groups were treated with budesonide, one session, and two sessions of WCT. Finally, eosinophil counts, the gene expressions, and the protein levels of interleukins IL-5, -13, and -33 were measured in bronchoalveolar lavage fluid (BALF) of mice. Lung tissues were removed and kept for histopathological evaluations. Both eosinophil counts and interleukin levels in BALFs were significantly diminished following WCT. Moreover, WCT prevented hyperplastic growth of goblet cells, overproduction of mucus, and inflammation of peribronchial and perivascular areas of lung tissue of mice compared to positive control group. Interestingly, the anti-inflammatory effects of WCT against asthma were comparable to budesonide. Our data suggested that the anti-asthmatic effects of WCT were mediated by reducing eosinophil trafficking and modulating Th2 inflammatory cytokines, leading to the histological changes of the lung. This may propose WCT as an efficient therapeutic approach to mitigate inflammatory complications of asthma. https://jtim.tums.ac.ir/index.php/jtim/article/view/404

Tehran University of Medical Sciences Traditional and Integrative Medicine 2476-5104 7 1 2022 03 09 52 63 Ardeshir Moayeri Department of Anatomy, Medical School, Ilam University of Medical Sciences, Ilam, Iran AND Biotechnology and Medicinal Plants Research Center, Medical School, Ilam University of Medical Sciences, Ilam, Iran Kholoud Ramz Department of Anatomy, Medical School, Ilam University of Medical Sciences, Ilam, Iran Elahe Karimi Biotechnology and Medicinal Plants Research Center, Medical School, Ilam University of Medical Sciences, Ilam, Iran Monireh Azizi Department of Anatomy, Medical School, Ilam University of Medical Sciences, Ilam, Iran Naser Abbasi Biotechnology and Medicinal Plants Research Center, Medical School, Ilam University of Medical Sciences, Ilam, Iran AND Department of Pharmacology, Medical School, Ilam University of Medical Sciences, Ilam, Iran Ali Aidy Biotechnology and Medicinal Plants Research Center, Medical School, Ilam University of Medical Sciences, Ilam, Iran Mahmoud Bahmani Biotechnology and Medicinal Plants Research Center, Medical School, Ilam University of Medical Sciences, Ilam, Iran 2021 06 01 2021 09 19 Finding more efficient agents with fewer side effects for the treatment of burns has been a concern for researchers. The current study aims to assess Aloe vera (L.) Burm.f. and Vitis vinifera L. extract combination (AVEC) effects on wound healing in rats compared with silver sulfadiazine (SSD). Identification of individual polyphenols of the plant extracts was performed by HPLC. The animals were randomly divided into twelve groups. Standard second-degree burn wounds were induced on the back. Groups were treated with Aloe vera (A.V) and Vitis vinifera (V.V) creams at concentrations of 0.5, 1, 1.5, and 2% with ED50 values of 1.5 ± 0.02 and 1.4 ± 0.08 %, respectively. The other group was treated with an AVEC cream (1.5%). The samples of burned skin tissue were collected from the rats for histopathological examination. To evaluate the expression of VEGF and TGFβ1, the real time-PCR method was used. Kaempferol was only detected in Aloe. This study revealed that AVEC cream exhibits significant wound healing activity. VEGF and TGFβ1 had a significant increase in the AVEC. Based on our findings, AVEC cream can be a therapy of choice for burn injuries. https://jtim.tums.ac.ir/index.php/jtim/article/view/443

Tehran University of Medical Sciences Traditional and Integrative Medicine 2476-5104 7 1 2022 03 14 64 72 Masoud Sadeghi Dinani Department of Pharmacognosy, School of Pharmacy, Isfahan University of Medical Sciences & Health Services, Isfahan, Iran Javad Rezapour Research Committee, School of Pharmacy, Isfahan University of Medical Science & Health Services, Isfahan, Iran Simindokht Soleimanifard Department of Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences & Health Services, Isfahan, Iran 2021 06 08 2021 09 07 Leishmaniasis is one of the infectious diseases in tropical countries that is seen as cutaneous, mucocutaneous and visceral forms. Due to the side effects, costs and effectiveness of anti-leishmaniasis drugs, many clinical trials have been conducted on the importance of plant-based substances against leishmaniasis. Therefore, the following study was performed to evaluate the therapeutic effects of Perovskia abrotanoides Kar. terpenoid fraction on cutaneous leishmaniasis in Balb/c mice. The ethanol: water (80:20) extract of the plant flowers was fractionated by Medium Pressure Liquid Chromatography using RP-18 column. The terpenoid-rich fraction was detected by TLC and HNMR analyses and evaluated for healing effects on cutaneous leishmaniasis in mice with concentrations of 0.8%, 1.6% and 3.2 µg/mL. The effect of that was evaluated using ANOVA statistical tests. The results indicate that terpenoid of P. abrotanoides in 3.2% concentration is effective in treating cutaneous leishmaniasis in mice and also increases the lifespan and decreases the parasite burden of infected mice. According to this result, it is suggested that the effectiveness of this extract on the treatment of cutaneous leishmaniasis to be evaluated as a clinical trial in humans. https://jtim.tums.ac.ir/index.php/jtim/article/view/446

Tehran University of Medical Sciences Traditional and Integrative Medicine 2476-5104 7 1 2022 03 14 73 86 Hanieh Nasrollahi Department of Analytical Chemistry and Pollutants, Shahid Beheshti University, 1983969411, Tehran, Iran Mehrnaz Karimi Department of Analytical Chemistry and Pollutants, Shahid Beheshti University, 1983969411, Tehran, Iran Farhad Raofie Department of Analytical Chemistry and Pollutants, Shahid Beheshti University, 1983969411, Tehran, Iran 2021 06 16 2021 08 06 Corchorus olitorius L. is a medicinal herb with anti-inflammatory, laxative, and tonic properties, which is effective on the treatment of cancer and tumors. In this study, the extraction efficiency of supercritical fluid extraction (SFE) and ultrasound-assisted extraction (UAE) of C. olitorius as well as their antioxidant activities were investigated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical. For this purpose, central composite block cube star and central composite design were employed to determine the optimal conditions. Thereafter, the qualification analysis of the effective ingredients of C. olitorius was done by LC-ESI-MS in negative mode. The results of LC-MS showed that C. olitorius includes phenolic and flavonoid compounds such as caffeic acid, p-coumaric acid, trans-ferulic acid, quercetin, naringenin, cirsiliol, cirsilineol, quercetrin, and naringin. Moreover, the SFE efficiency of extraction and IC50 value was obtained 4.25% and 1208.99 µg/mL, respectively. Also, the UAE efficiency of extraction and IC50 of antioxidant activity was obtained as 15.29% and 994.284 µg/mL, respectively. These results confirmed that the efficiencies of extraction and antioxidant activity of UAE were higher than that of SFE; however, the SFE is an environmentally friendly method and consumed less organic solvent. https://jtim.tums.ac.ir/index.php/jtim/article/view/456

Tehran University of Medical Sciences Traditional and Integrative Medicine 2476-5104 7 1 2022 03 14 87 103 EN Syed Zubair Ali Department of Ilmul Saidla, National Institute of Unani Medicine, Kottigepalya, Magadi main road, Bengaluru-560091, India Khaleequr Rahman Department of Ilmul Saidla, National Institute of Unani Medicine, Kottigepalya, Magadi main road, Bengaluru-560091, India Arshiya Sultana Department of Ilmul Qabalat wa Amraze Niswan, National Institute of Unani Medicine, Kottigepalya, Magadi main road, Bengaluru-560091, India 2021 07 01 2021 09 01 Jushanda (decoction), often used in traditional medicine, has many drawbacks like disagreeable taste, bulky dose, cumbersome preparation, and short stability. Therefore, in the present study, jushanda nazla (JN) was modified and optimized into a sugar-based (SBS) and sugar-free (SFS) syrup dosage form and evaluated for various physicochemical parameters, microbial contaminations and antimicrobial activities. JN was concentrated and reduced to minimum quantity by heating and twelve batches of SBS and five batches of SFS were prepared for optimization. Out of these, the best batch of SBS and SFS were selected based on consistency and minimum bulk. The best batches were further evaluated for the physicochemical parameter, microbial and heavy metal contamination. The finished products were also evaluated for antimicrobial activity against selected microbes. SBS was optimized with 170 mL JN reduced to 50 mL, sugar 40% (w/v) and consistency of one wire. SFS was optimized with 170 mL JN reduced to 30 mL, and 96 mg of aspartame. Organoleptic characters, ash value, viscosity, specific gravity and pH of finished products were satisfactory. The concentration of total phenolic, flavonoid, tannin, alkaloid and glycyrrhizin and chlorogenic acid were comparative in JN, SBS and SFS. SBS and SFS passed the WHO guideline for microbial and heavy metal contamination. Finished products showed significant antimicrobial activity against Streptococcus pyogenes, Streptococcus pneumoniae, Haemophilus influenzae and Salmonella. Analytical data of SBS and SFS showed significant optimistic results hence, generated data can be used for future reference. However, developed formulations should be further evaluated for their stability, safety and clinical efficacy. https://jtim.tums.ac.ir/index.php/jtim/article/view/470

Tehran University of Medical Sciences Traditional and Integrative Medicine 2476-5104 7 1 2022 03 14 104 123 Quadri Nurudeen Department of Biological Sciences, Al-Hikmah University, Ilorin, Nigeria Saoban Salimon Department of Biological Sciences, Al-Hikmah University, Ilorin, Nigeria Mansurat Falana Department of Biological Sciences, Al-Hikmah University, Ilorin, Nigeria Musa Yakubu Department of Biochemistry, Faculty of Life Sciences, University of Ilorin, Ilorin, Nigeria Musbau Akanji Department of Biochemistry, Faculty of Life Sciences, University of Ilorin, Ilorin, Nigeria 2021 06 25 2021 10 02 Over generations, several indigenous knowledge on the use of medicinal plants have been lost due to a lack of interest of the upcoming generation and reluctancy of the older generations to pass on their knowledge. This survey was set about to preserve and share the knowledge of the Ilorin Emirate Clan in the management of female sexual dysfunction and infertility (FSDI). The survey was conducted across three major markets (Shao, Jimba-Oja and Oke-Oyi) and ethnobotanical data on medicinal plants, mode of preparation, route of administration and demographic information were collected from volunteers using a semi-structured questionnaire, oral or virtual interviews. A total of 47 plant species belonging to 28 families were identified from 85 willing respondents. Phyllanthus amarus Schumach. & Thonn. was the most frequently cited plant with a citation frequency of 31.76% and a fidelity level of 57.75% whereas Xylopia aethiopica (Dunal) A.Rich. was the least cited plant with a citation frequency of 1.18% and a fidelity level of 1.12%. The highest informant consensus factor computed for Shao market, Jimba-Oja and Oke-Oyi were 0.93, 0.57 and 0.84 for P. amarus, Sarcocephalus latifolius (Sm.) E.A.Bruce and Cassia fistula L., respectively. This study provides a comprehensive insight into the medicinal plants in our society that are of importance in the management of female sexual dysfunction and infertility. The data collected would promote the conservation of invaluable indigenous knowledge and highlight a broad selection of medicinal plants that could be subjected to further pharmacological and clinical investigation for their potential role in the treatment of FSDI. https://jtim.tums.ac.ir/index.php/jtim/article/view/467