Tehran University of Medical Sciences Traditional and Integrative Medicine 2476-5104 1 1 2015 11 11 1 2 EN Hossein Rezaeizade Department of Traditional Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran 2015 10 05 2015 10 05 No Abstract https://jtim.tums.ac.ir/index.php/jtim/article/view/1 https://jtim.tums.ac.ir/index.php/jtim/article/download/1/24

Tehran University of Medical Sciences Traditional and Integrative Medicine 2476-5104 1 1 2015 11 11 3 17 EN Malihe Safavi Pharmaceutical Sciences Research Center and Persian Medicines and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran Mohammad Reza Shams-Ardakani Persian Medicines and Pharmacy Research Center and Department of Pharmacognosy, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran Maryam Sadat Seyedbagheri Persian Medicines and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran Alireza Foroumadi Pharmaceutical Sciences Research Center and Persian Medicines and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran 2015 10 05 2015 10 05 Peptic ulcer and gastritis are common and universal disease which affect up to 50% of the world’s adult population. Helicobacter pylori is a major cause of chronic-active gastritis and primary duodenal ulcers, and is strongly linked to gastric cancer. H. pylori induce chronic gastritis in virtually all infected patients. Chronic gastritis induced by H. pylori increases the risk for a wide spectrum of clinical outcomes, ranging from peptic ulcer disease and atrophic gastritis to gastric adenocarcinoma and gastric mucosal lymph proliferative diseases. Extracts of several plants including Cinnamomum zeylanicum, Coriandrum sativum, Malus domestica, Phyllanthus emblica, Pistacia lentiscus, Portulaca oleracea, Punica granatum, and Terminalia chebula have been used in Iranian traditional medicine as therapeutic agents for gastritis and peptic ulcer diseases. The information on all of these remedies was derived from all available old sources such as traditional books. According to new database the mechanisms of action for some of these plants are known. For example T. chebula causes improvement in the secretory status of Brunner’s gland and also, aqueous extracts of this plant have anti-bacterial activity against H. pylori. The information of more recent studied Iranian folk medicinal plants such as Camellia sinensis, Geum iranicum, Rheum ribes, Salvia mirzayanii, Sambucus ebulus, Stachys lavandulifolia, Stachys setifera, Trachyspermum copticum, and Zataria multiflora are presented in this review. The medicinal properties of these folk plants are attributed mainly to the presence of natural anti-oxidants and potent anti H. pylori activity. It is suggested that an evaluation of the effects of these plants on different aspects of gastric disorders should be performed and further studies are necessary on the other traditional and folk medicinal plants of Iran. https://jtim.tums.ac.ir/index.php/jtim/article/view/2 https://jtim.tums.ac.ir/index.php/jtim/article/download/2/27

Tehran University of Medical Sciences Traditional and Integrative Medicine 2476-5104 1 1 2015 11 11 18 27 EN Nastaran Ebadi Department of Traditional Pharmacy, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran Fatemeh Masoomi Department of Traditional Pharmacy, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran Maryam Yakhchali Department of Traditional Pharmacy, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran Seyede Nargess Sadati Lamardi Department of Traditional Pharmacy, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran Mohammad Reza Shams-Ardakani Department of Traditional Pharmacy, School of Persian Medicine AND Department of Pharmacognosy, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran Omid Sadeghpour Department of Herbal and traditional Medicine, Research Institute for Islamic and Complementary Medicine, Iran University of Medical Sciences, Tehran, Iran Azadeh Raiesdana Department of Traditional Pharmacy, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran Farid Ramezany Department of Traditional Pharmacy, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran 2015 10 05 2015 10 05 Similar to other traditional medicines, Traditional Persian Medicine (TPM) applies its special terms for description of drug functions. Among these functions, convoy (Mobadregh) medicines are unique, mainly due to the interaction of them with the pharmacokinetics of other herbal medicines. These interactions  suggest  the  potential  herb-herb  and  herb-synthetic  drug  interactions  with  convoy medicines that necessitate the study and precise definition of them. For this purpose, old Persian medical texts and pharmacopeias were searched and investigated for the name of convoys, their target organ(s), primary qualities, and other functions. Relationships among convoy and other functions based on notes on the texts and statistical analysis were considered. Based on the old resources, the convoys were defined as modifiers (of drug actions), which facilitate access of drugs and foods to whole body or organs. The concept of targeting in some convoys was also implied as well as other disciplines such as Traditional Chinese Medicine and Ayurveda. Descriptive analysis of the available data showed that most of the convoys contain warm and dry primary qualities. Anti-blockage and thin consistencies are main characteristics of this class of drugs. Statistical analysis also showed diuretic activity is another major characteristic of them. Other functions such as discutient, attenuant, and tonic are capable to assist convoying by thinning of humors and organs. Analysis of TPM literature shows the presence of a logic approach in the formulation of compound drugs. Owing to the potential influence of convoys on the pharmacokinetic profile of other herbs and synthetic drugs, it is necessary to conduct future studies to evaluate these interactions in TPM and modern medicine. https://jtim.tums.ac.ir/index.php/jtim/article/view/3 https://jtim.tums.ac.ir/index.php/jtim/article/download/3/28

Tehran University of Medical Sciences Traditional and Integrative Medicine 2476-5104 1 1 2015 11 11 28 34 EN Bahram Delfan Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran Mahmoud Bahmani Food and Beverages Safety Research Center, Urmia University of Medical Sciences, Urmia, Iran Hossein Kazemeini Department of Clinical Sciences, School of Veterinary Medicine, Shabestar Branch, Islamic Azad University, Shabestar, Iran Arman Zargaran Pharmaceutical Sciences Research Center AND Department of Traditional Pharmacy, School of Pharmacy AND Research Office for the History of Persian Medicine, Shiraz University of Medical Sciences, Shiraz, Iran Mahmoud Rafieian Kopaei Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran Majid Asadi Samani Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran Somayeh Shahsavari Clinical Microbiology Research Center, Ilam University of Medical Sciences, Ilam, Iran 2015 10 05 In  the  recent  decades,  hyperlipidemia  has  considerably  increased  with  the  development  of machine life. It has been accompanied by diseases such as hypothyroidism, liver and kidney diseases, diabetes, chronic kidney disease, as well as obesity and can cause complications such as atherosclerosis, hypertension, increased risk of stroke, and fatty liver disease. Lorestan province in the west of Iran has an ancient history in traditional medicine and abundance of medicinal plants. So, this study aimed to identify effective medicinal plants for hyperlipidemia in this province and report its effects on the treatment of hyperlipidemia and the related diseases. This study was conducted during 2008-2010 by 11 trained health volunteers with the cooperation of Food and Drug Chancellor, Razi Herbal Medicine Research Center, and Health and Treatment Networks of Khorramabad, Dorud, Poldokhtar, Boroujerd, Aleshtar, Aligoodarz, Kouhdasht, and Noorabad. Questionnaire method was used, and a specific questionnaire was designed to gather information on traditional herbal therapy, which has been used to reduce hyperlipidemia in this province. The results of the questionnaire analysis indicated that in lorestan province, nine species of medicinal plants from eight plant families were used for treating hyperlipidemia. Leaves were mostly used plant part (42%) and predominantly used herbal preparations were raw plants (46%). Summer with 38% of frequency was the most reported season for collecting medicinal plants effective for hyperlipidemia in this province. Cichorium intybus was the most frequently used medicinal plant (73.33%). Novel scientific studies support the ethnomedicinal use of some of the mentioned plants in the lorestan province of Iran for the treatment of hyperlipidemia. However, further clinical investigations are needed to confirm their efficacy and safety. https://jtim.tums.ac.ir/index.php/jtim/article/view/4 https://jtim.tums.ac.ir/index.php/jtim/article/download/4/29

Tehran University of Medical Sciences Traditional and Integrative Medicine 2476-5104 1 1 2015 11 11 35 39 EN Masumeh Mobli Department of Traditional Pharmacy, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran Ismaeil Haririan Department of Pharmaceutics, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran Gholamreza Amin Department of Traditional Pharmacy, School of Persian Medicine AND Department of Pharmacognosy, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran Mohammad Kamalinejad Department of Pharmacognosy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Mannan Hajimahmoodi Department of Traditional Pharmacy, School of Persian Medicine AND Department of Drug and Food Control, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran 2015 10 05 2015 10 05 Myrtus communis L. is a medicinal herb that widely used in Iranian traditional medicine. Myrtle leaves extracts have been studied and a variety of products made from myrtle leaves in Iran and other countries, but only recently, the berries have been the object of scientific interest. In this study, we prepared herbal syrup from myrtle berries aqueous extract and standardized based on total phenols (Folin-Ciocalteu method) and gallic acid (Rhodanine assay) content. Stability tests including phytochemical assay and microbial limit tests were conducted during 3 months of the storage period and pH and viscosity variation of the product were recorded. pH and viscosity of syrup have not been significant changes during 3 months of storage. Evaluation of polyphenol and free gallic acid in myrtle berries syrup was investigated showing that myrtle syrup is microbially and phytochemically stable in the initial 3 months of the storage period. https://jtim.tums.ac.ir/index.php/jtim/article/view/5 https://jtim.tums.ac.ir/index.php/jtim/article/download/5/30

Tehran University of Medical Sciences Traditional and Integrative Medicine 2476-5104 1 1 2015 11 11 40 43 EN Kolavanahalli Pillegowda-Smitha Department of Pharmaceutics, Sri K.V. College of Pharmacy, Chickballapur, Karnataka, India Kuruba Srinivas-Kulashekar Department of Pharmacology, Sri K.V. College of Pharmacy, Chickballapur, Karnataka, India Thotlaganahalli Krishnappa-Pavithra Department of Pharmaceutics, Sri K.V. College of Pharmacy, Chickballapur, Karnataka, India Bagepalli Srinivas-Ashok-Kumar Department of Pharmacognosy, Sri K.V. College of Pharmacy, Chickballapur, Karnataka, India Gopi Setty-Saran Department of Pharmaceutics, Sri K.V. College of Pharmacy, Chickballapur, Karnataka, India 2015 10 05 2015 10 05 Sitopaladi Churna is an ayurvedic formula, traditionally used as anti-inflammatory, carminative, sedative, expectorant, anti-infective, and various respiratory disorders. The aim of the present study is to screening for alpha amylase (α-amylase) inhibition activity of aqueous extract of Sitopaladi Churna. In vitro α-amylase inhibition activity of Sitopaladi Churna was screened by the 3,5-dinitrosalicylic acid method. Sitopaladi Churna showed potent (α-amylase) inhibitory activity with an IC50  - 46.38 µ g/ml. Thus, Sitopaladi Churna may consider as a remedy for diabetes and other  insulin  resistance-related  diseases;  however,  animal  and  human  studies  are  needed  to confirm this activity. https://jtim.tums.ac.ir/index.php/jtim/article/view/6 https://jtim.tums.ac.ir/index.php/jtim/article/download/6/31

Tehran University of Medical Sciences Traditional and Integrative Medicine 2476-5104 1 1 2015 11 11 44 46 EN Nassim Rahmani Institute of Biotechnology, College of Agriculture, Shiraz University, Shiraz, Iran Zohreh Heydarian Institute of Biotechnology, College of Agriculture, Shiraz University, Shiraz, Iran 2015 10 05 2015 10 05 Salicornia is one of the halophyte plants that grow in salt marshes and beaches. The aim of the present study is to evaluate the in vitro antifungal activity of Salicornia iranica, an endemic species of Iran, in two fungal species, including Aspergillus niger and Candida albicans. For this purpose, S. iranica 70% of ethanolic extract was prepared and mixed in plates with agar medium containing A. niger and C. albicans separately and allowed to gelatinize. Fungal samples were placed on each plate by the sampler. After absorption of microbial suspension into the agar plates, all of them were incubated at 25 °C for 72 hours. The results showed that S. iranica has no inhibitory  effect  on  tested  fungi.  Since  the  antimicrobial  activity  of  Salicornia  have  been attributed to fatty acid methyl esters, negative antifungal activity may be due to the lack of this compound in ethanolic extract, degradation of them through extraction, or the resistance of tested fungal species to the related compounds. https://jtim.tums.ac.ir/index.php/jtim/article/view/7 https://jtim.tums.ac.ir/index.php/jtim/article/download/7/32

Tehran University of Medical Sciences Traditional and Integrative Medicine 2476-5104 1 1 2015 11 11 47 51 EN Soodabeh Bioos Department of Iranian Traditional Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran Esmail Nazem Department of Iranian Traditional Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran Mansoor Keshavarz Department of Iranian Traditional Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran Marzieh Beigom Siahpoosh Research Institute for Islamic and Complementary Medicine, Iran University of Medical Sciences, Tehran, Iran Farnaz Sohrabvand Department of Obstetrics and Gynecology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran Hamid Sohanaki Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran Fatemeh Nejatbakhsh Department of Iranian Traditional Medicine, School of Traditional Medicine, Tehran University of Medical Sciences, Tehran, Iran 2015 10 05 2015 10 05 Infertility is defined as the inability to conceive after 12 or more months of regular intercourse without  contraception.  Sperm abnormalities  are  introduced  as  20-47%  of  infertility  etiology. Idiopathic  male  subfertility  is  common  (40-50%).  In  the  Iranian  traditional  medicine,  many natural drugs are used for enhancing fertility. This case series was an effort to understand the role of an Iranian traditional formulation in conception. For this purpose, 13 men with infertility and idiopathic oligoasthenoteratospermia were treated by 10 g Majoon-e Loboob twice daily. 11 (84.6%) of their wives became pregnant after 4.8 ± 2.0 months. In men with severe oligoasthenospermia (< 0.1 × 106/ml), no pregnancy occurred and their spermogram remained unchanged. However, libido and erectile function showed improvement in all patients. No adverse events have been reported by patients. Majoon-e Loboob could be considered as a complementary medicine  for  treatment  of  idiopathic  infertility.  Some  of  the  natural  components  in  this formulation have proven pharmacological activity in conception including Zingiber officinale and Myristica fragrans. https://jtim.tums.ac.ir/index.php/jtim/article/view/8 https://jtim.tums.ac.ir/index.php/jtim/article/download/8/33