Tehran University of Medical Sciences Traditional and Integrative Medicine 2476-5104 8 3 2023 07 23 299 315 Mohammad Sheibani Department of Pharmacology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran AND Razi Drug Research Center, School of Medicine, Iran University of Medical Sciences, Tehran, Iran Maryam Shayan Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran Majid Jafari-Sabet Department of Pharmacology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran AND Razi Drug Research Center, School of Medicine, Iran University of Medical Sciences, Tehran, Iran Ali Mohammad Sharifi Department of Pharmacology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran AND Razi Drug Research Center, School of Medicine, Iran University of Medical Sciences, Tehran, Iran AND Stem Cell and RM Research Center, Iran University of Medical Sciences, Tehran, Iran AND Tissue Engineering Group, (NOCERAL), Department of Orthopedics Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia 2022 11 07 2023 01 29 Phytomedicines, also known as plant-derived drugs, possess preventive and therapeutic effects. Herbal medicines exert a wide range of biological and medicinal properties along with beneficial advantages, including less side-effects and lower costs compared to their chemical counterparts. Herbal derivates form basis of many available chemical medicines such as Atropine, Hyoscyamine, Quinine, Colchicine, Digoxin, Codeine, and Morphine. Asian and African populations consume herbal medicine for therapeutic purposes by 60-80%. In the United States, 25% of pharmaceutical medications have at least one herbal-derived ingredient in their structure. Regenerative Medicine (RM) employs stem cells and tissue engineering technology to restore injured cells and repair tissue damage. Stem cells are undifferentiated cells, which can be differentiated into numerous cells. Mesenchymal Stem Cells (MSCs) as multipotent stem cells are the most frequently used stem cells in RM, which can be differentiated into several cell types such as adipocytes, osteocytes, and chondrocytes. Bone disorders and cartilage injuries are not responsive to currently available therapies; thus, researchers have focused on herbal-based stem cell therapies. The present study aimed to review the mechanism underlying the therapeutic application of phytomedicines in the RM and their efficacy in osteogenesis and chondrogenesis. https://jtim.tums.ac.ir/index.php/jtim/article/view/873