Tehran University of Medical Sciences Traditional and Integrative Medicine 2476-5104 7 3 2022 09 05 302 309 Fataneh Hashem-Dabaghian Department of Traditional Medicine, Institute for studies in Medical History, Persian and Complementary Medicine, School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran Fatemeh Sadat Hosseini-Baharanchi Minimally Invasive Surgery Research Center, Iran University of Medical Sciences, Tehran, Iran AND Department of Biostatistics, School of Public Health, Iran University of Medical Sciences, Tehran, Iran Fatemeh Yusefi Research Institute for Islamic and Complementary Medicine, School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran Samira Kadkhodaei School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran 2021 12 27 2022 04 08 To develop and validate “Treatment Satisfaction with Traditional Medicines” Questionnaire (TSTMQ), a preliminary 22-item instrument was designed. Content validity ratio (CVR), content validity index (CVI), Intra-class correlation (ICC), and Cronbach alpha were measured, and exploratory and confirmatory factor analysis (EFA and CFA) were conducted. Data were analyzed using SPSS (17) and LISREL softwares (8.8). Finally, TSTMQ with 14 items and in three domains were confirmed after measuring CVR (> 0.62), CVI (> 0.79) and EFA. ICC for the entire questionnaire was 0.99 (95% CI: 0.95-0.99) (P<0.001), and Cronbach alpha was also 0.87. In CFA, all factor loadings and t-values were greater than 0.3 and 1.96, respectively. Also, χ2/df, RMSE and GFI were 2.6, 0.062, and 0.94, respectively. This study showed that the TSTMQ is a standard tool to measure treatment satisfaction with traditional medicine. https://jtim.tums.ac.ir/index.php/jtim/article/view/606