Tehran University of Medical Sciences Traditional and Integrative Medicine 2476-5104 7 3 2022 09 05 294 301 Maryam Azimi Gastroenterology and Hepatology Research Center, Kerman University of Medical Sciences, Kerman, Iran Fatemeh Sadat Hasheminasab Pharmacology Research Center, Zahedan University of Medical Sciences, Zahedan, Iran Bahram Chooban Shahid Mofateh Hospital, Shahid Beheshti University of Medical sciences, Tehran, Iran Nezhat Shakeri Department of Biostatistics, School of Allied Medical Sciences, Shahid Beheshti University of Medical sciences, Tehran, Iran Saeedeh Ghasemi Shahid Mofateh Hospital, Shahid Beheshti University of Medical sciences, Tehran, Iran Azam Farokhi Shahid Mofateh Hospital, Shahid Beheshti University of Medical sciences, Tehran, Iran Roshanak Mokaberinajad Department of Traditional Medicine, School of Persian Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran 2021 12 03 2022 04 28 COVID-19 spread rapidly around the world from the end of 2019. Hot footbath is a simple ancient technique, which has been used to alleviate many disorders. We aimed to investigate the effect of hot footbath in hospitalized COVID-19 patients. This open-label randomized controlled trial was conducted in Iran with allocation ratio of 1:1, with final sample size of 35 patients in each group. The intervention group received hot footbath (immersion of feet into the hot water at 42 °C, 10 cm above the ankles for 20 minutes, and then kept warm for 5 minutes) once a day for a week, in addition to the conventional therapy. The control group received only the conventional therapy; the primary outcomes evaluated were fever, respiratory rate, cough, fatigue, and myalgia; whereas admission rate, ICU admission, and mortality were assessed as the secondary outcomes. Except for cough intensity, cough frequency and fatigue (p value < 0.05), no significant differences were observed between the two groups in the primary and secondary outcomes. No adverse events were reported. Hot footbath can be used as a non-invasive, highly acceptable, and complementary technique to alleviate COVID-19 patients without any needs to expensive or special equipment; nevertheless, further studies with larger sample sizes are needed so as to accurately evaluate the effectiveness of hot footbath on clinical symptoms of COVID-19. https://jtim.tums.ac.ir/index.php/jtim/article/view/598