Tehran University of Medical Sciences Traditional and Integrative Medicine 2476-5104 6 3 2021 09 19 184 192 EN Mehrdad Goudarzi Traditional and Complementary Medicine Research Center, Arak University of Medical Sciences, Arak, Iran Maryam Eskandari Mehrabadi Department of Biochemistry, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran Zahra Salemi Department of Biochemistry, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran Jamal Amri Traditional and Complementary Medicine Research Center, Arak University of Medical Sciences, Arak, Iran Mitra Noori Department of Biology, Faculty of Sciences, Arak University, Arak, Iran Ali Rahbari Department of Pathology, Arak University of Medical Sciences, Arak, Iran Amirhossein Alizadeh Department of Biochemistry, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran Atefeh Soltani Department of Medical Sciences, Islamic Azad University, Aligodarz, Iran Mitra Panahi Department of Biology, Alexander College, Vancouver, Canada Farshad Eskandari Mehrabadi Islamic Azad University of Ayatollah Amoli, Amol, Iran 2021 01 20 2021 04 22 We want to evaluate the effect of Allium noeanum Reut. ex Regel (Bonsor) known (traditional medicine agent) in calcium oxalate stones in kidney. 36 male rats were divided into 6 groups. I: healthy model + water, II: negative model + 1% ethylene glycol in water, III: 750 mg/kg of total extract +1% of ethylene glycol in water(Prevention), IV: 250 mg/kg flavonoid extract +1% of ethylene glycol in water (Prevention), V: 1500 mg/kg of total extract from 15th day+ 1% of ethylene glycol in water (Treatment), VI: 500 mg/kg of flavonoid extract from 15th of the study + 1% of ethylene glycol in water (Treatment).24-hour urine and blood samples were collected in 30th day for analysis. Pathology of kidneys was checked. Serum urea, uric acid, creatinine and urine calcium and oxalate were significantly increased, urine citrate was decreased in group II Vs I. (P < .05). Extract administration significantly decreased serum creatinine, urea and uric acid. Urine calcium and oxalate significantly decreased in treated groups. Urine calcium levels were significantly decreased in treated rats, but urine citrate levels were increased Vs group II. (P < .05). No crystal accumulation and tubular cast were observed in prevention groups. Hydroalcholic extract of Allium noeanum was able to reduce urine oxalate. https://jtim.tums.ac.ir/index.php/jtim/article/view/272