Tehran University of Medical Sciences Traditional and Integrative Medicine 2476-5104 11 2 2026 06 28 2152 2152 Fatemeh Rashidi Student Research Committee, school of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran Sepideh Hajian Department of Midwifery, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran Mojgan Zarei Salehabadei Student Research Committee, school of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran Fatemeh Alahverdi Student Research Committee, school of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran Fatemeh Kermani Student Research Committee, school of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran Zohre Keshavarz Midwifery and Reproductive Health Research Center, Department of Midwifery, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran 2025 05 28 2025 10 17 Male infertility accounts for 50% of infertility cases among couples. Medical treatments may have side effects; while curcumin has been explored as a therapeutic option due to its antioxidant properties and fewer side effects. This study assessed the effect of curcumin on sperm parameters. This systematic review focused on experimental human studies, searching databases such as PubMed, Web of Science, Scopus, Embase, as well as trial registration databases including trialsearch.who.int and clinicalTrials.gov. Additionally, Persian databases like SID and Magiran were searched up to August 2024, without any time or language restrictions, using keywords related to ″male infertility″, ″sperm analysis″, ″sperm freezing″, and ″curcumin″. The quality of the studies was assessed using the valid and reliable tool from the Joanna Briggs Institute (JBI) for semi-experimental studies. This systematic review was conducted using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Totally, out of 537 identified studies, 11 studies remained that aligned with the objectives of the current research. The results of the systematic review indicated that curcumin, at doses exceeding 200 micromoles, inhibited sperm motility; while lower doses enhanced it. Furthermore, under oxidative stress conditions resulting from freezing, curcumin improved both sperm motility and viability. Curcumin, as a potent antioxidant, can enhance sperm motility, viability, and DNA integrity; while at higher doses, it may act as a contraceptive agent. Its effects are dose- and time-dependent, and it may help reduce oxidative stress and damage associated with sperm freezing. Further clinical studies are recommended to explore the practical application of curcumin in the treatment of infertility. https://jtim.tums.ac.ir/index.php/jtim/article/view/2152