Tehran University of Medical Sciences Traditional and Integrative Medicine 2476-5104 5 1 2020 03 16 14 18 Hoorieh Mohammadi Kenari Research Institute for Islamic and Complementary Medicine, School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran Gholamreza Kordafshari School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran Maryam Moghimi Masiha Teb Shomal Knowledge-based cooperation, Sari, Iran 2020 01 18 2020 03 04 Acne is a multifactorial disease which causes many harmful physical and psychological effects for patients. Several therapies are used in conventional medicine for acne, but most of these methods are not stable and cause side effects. Therefore, it is considered to use complementary medicine alongside conventional therapies to achieve better results. In this article, a patient with chronic and severe acne is presented which is treated by a combination of temperament modification and leech therapy based on Persian medicine. https://jtim.tums.ac.ir/index.php/jtim/article/view/215