Tehran University of Medical Sciences Traditional and Integrative Medicine 2476-5104 11 3 2026 09 29 2039 2039 Fatine Aissani Laboratoire des Silicates, Polymères et des Nanocomposites (LSPN), Université 8 Mai 1945 Guelma, BP 4010, Guelma 24000, Algeria AND Faculté des Sciences de la Nature et de la Vie et Sciences de la Terre et de l'Univers Département de Biologie, Université 8 Mai 1945 Guelma BP 401, Guelma 24000, Algeria Marwa Yakhlef Laboratoire des Silicates, Polymères et des Nanocomposites (LSPN), Université 8 Mai 1945 Guelma, BP 4010, Guelma 24000, Algeria AND Faculté des Sciences de la Nature et de la Vie et Sciences de la Terre et de l'Univers Département de Biologie, Université 8 Mai 1945 Guelma BP 401, Guelma 24000, Algeria Djamila Benouchenne Laboratory of Genetic Biochemistry and Plants Biotechnology (GBBV), Faculty of Nature and Life Sciences, University of Mentouri Brothers Constantine 1, 25000 Constantine, Algeria AND Higher National School of Biotechnology, Taoufik KHAZNADAR, Nouveau Pôle universitaire Ali Mendjeli,BP, E66, 25100 Constantine, Algeria Sana Amiri Faculté des Sciences de la Nature et de la Vie et Sciences de la Terre et de l'Univers Département de Biologie, Université 8 Mai 1945 Guelma BP 401, Guelma 24000, Algeria Narimane Mejdoub Faculté des Sciences de la Nature et de la Vie et Sciences de la Terre et de l'Univers Département de Biologie, Université 8 Mai 1945 Guelma BP 401, Guelma 24000, Algeria Fatima Merabti Faculté des Sciences de la Nature et de la Vie et Sciences de la Terre et de l'Univers Département de Biologie, Université 8 Mai 1945 Guelma BP 401, Guelma 24000, Algeria Muhd Hanis Md Idris Drug Discovery Center (DDC), Integrative Pharmacogenomics Institute (iPROMISE), Universiti Teknologi MARA (UiTM) Selangor , Puncak Alam Campus, 42300 Bandar Puncak Alam, Selangor, Malaysia AND School of Biology, Faculty of Applied Sciences, Universiti Teknologi MARA, 40450 Shah Alam, Selangor, Malaysia Sofiane Boudalia Laboratoire de Biologie, Eau et Environnement, Université 8 Mai 1945 Guelma, BP 4010, Guelma 24000, Algeria 2025 03 18 2026 06 12 Algeria is characterized by a rich and diverse flora frequently used for therapeutic purposes. In this study, we conducted the first survey examining indigenous knowledge of medicinal and aromatic plants (MAPs) in the Guelma region of Algeria. A total of 500 in-person and focus group interviews were conducted with pharmacists, herbalists, practitioners, and healers. The objective was to determine the flora used by the population for treating metabolic disorders and closely associated inflammatory conditions. Fidelity Level (FL), Plant Part Value (PPV), Use Value (UV), Relative Frequency of Citation (RFC), and Family Use Value (FUV) were determined. The results indicate that MAPs are widely used, particularly among individuals aged over 60 years (46.4%), with women using them more frequently than men (53.8% versus 46.2%). The PPV analysis highlighted that leaves are the most commonly used plant part (0.98), and the oral route is the primary method of administration (56%). Diabetes is the most prevalent metabolic disorder treated (15%), with decoction being the preferred preparation method (26%). A total of 109 medicinal plants from 48 botanical families were recorded. The Lamiaceae family was the most abundant (10 species). This study emphasizes the significance of preserving local knowledge, which is vital for discovering new drugs. https://jtim.tums.ac.ir/index.php/jtim/article/view/2039