Tehran University of Medical Sciences Traditional and Integrative Medicine 2476-5104 4 4 2019 12 22 191 199 Mohaddese Mirzapour Department of Persian Medicine, School of Persian Medicine, Babol University of Medical Sciences, Babol, Iran Morteza Mojahedi Department of Persian Medicine, School of Persian Medicine, Babol University of Medical Sciences, Babol ,Iran AND Traditional Medicine and His tory of Medical Sciences Research Center, Health Research Ins titute, Babol University of Medical Sciences, Babol, Iran AND Department of His tory of Medical Sciences, School of Persian Medicine, Babol University of Medical Sciences, Babol, Iran Javad Shokri Research Center for Infectious Diseases and Tropical Medicine, Health Research Center, Babol, University of Medical Sciences, Babol, Iran Soraia Khafri Department of Statistic and Epidemiology, School of Medicine, Babol University of Medical Sciences, Babol, Iran Zahra Memariani Department of Persian Medicine, School of Persian Medicine, Babol University of Medical Sciences, Babol ,Iran AND Traditional Medicine and His tory of Medical Sciences Research Center, Health Research Ins titute, Babol University of Medical Sciences, Babol, Iran 2019 09 17 2019 10 08 Functional dyspepsia (FD) is a highly prevalent condition with high impact on healthcare costs. Considering the complimentary therapies options like phytotherapy, this study aimed to investigate the efficacy and safety of Nardostachys jatamansi (D.Don) DC. extract in sixteen FD patients. The subjects received capsules of 500 mg N. Jatamansi, 3 times daily before meals for 30 days. The severity of early satiation and postprandial fullness were assessed by self-report of improvement at least 50% of symptoms and other FD symptoms assessed by Gastrointestinal Symptom Rating Scale (GSRS) before intervention and at end of treatment. The mean GSRS score level decreased significantly after intervention among study population. Five patients had chief complaint of early satiety and post prandial fullness who all of them reported 50% improvement. According to the results N. jatamansi seems to be effective in patients with refractory FD. Randomized clinical studies seem to be required. https://jtim.tums.ac.ir/index.php/jtim/article/view/201