Tehran University of Medical Sciences Traditional and Integrative Medicine 2476-5104 4 4 2019 12 22 181 190 Mohadese Kamali Department of Persian Medicine, School of Persian Medicine, Kerman University of Medical Sciences, Kerman, Iran AND Neurology Research Center, Kerman University of Medical Sciences, Kerman, Iran Haleh Tajadini Department of Persian Medicine, School of Persian Medicine, Kerman University of Medical Sciences, Kerman, Iran AND Neurology Research Center, Kerman University of Medical Sciences, Kerman, Iran Rostam Seifadini Neurology Research Center, Kerman University of Medical Sciences, Kerman, Iran Mitra Mehrabani Herbal and Traditional Medicines Research Center, Kerman University of Medical Sciences, Kerman, Iran Yones Jahani Modeling in Health Research Center, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran Hoda Kamali Neurology Research Center, Kerman University of Medical Sciences, Kerman, Iran 2019 08 16 2019 10 22 Headache is one of the most common public health problems in the world, which causes patients to see a doctor. Migraine is the second most common cause of headaches after tension headaches. This study is a randomized, double blinded, placebo - controlled clinical trial, using SF36 questionnaire, to evaluate the effect of combination of Viola odorata L., Rosa damascena Mill. and Coriandrum sativum L. on the quality of life, in patients with migraine after 4 weeks. In all domains of the SF36 questionnaire, the scores after intervention in the drug group were significantly higher than the control group after 4 weeks. This study showed that, combination of V. odorata, R. damascena and C. sativum, improves the quality of life of patients with migraine. https://jtim.tums.ac.ir/index.php/jtim/article/view/199