Tehran University of Medical Sciences Traditional and Integrative Medicine 2476-5104 11 1 2026 03 23 1811 1811 Disha Hazarika Department of Applied Biology, University of Science and Technology, Meghalaya, Ri-Bhoi, Techno City, Killing Road, Baridua, Meghalaya, India Priyanka Shankarishan Department of Applied Biology, University of Science and Technology, Meghalaya, Ri-Bhoi, Techno City, Killing Road, Baridua, Meghalaya, India 2024 10 22 2025 09 13 Northeast India is a repository of rich plant resources and traditional knowledge of medicinal plants. These plants are in use by different ethnic groups of the region for various ailments and diseases. This paper reviews the ethnobotanical and therapeutic applications of medicinal plants known to various ethnic group in Northeast India that have been passed down through generations. It identifies the key bioactive compounds from the plants responsible for anticancer activities, making them potential chemopreventive agents. Furthermore, the paper also underlines the synergistic effects of these plants when combined with chemotherapeutic drugs. Thus, shedding light on combinatorial approach that can aim to enhance the effectiveness of cancer treatment. https://jtim.tums.ac.ir/index.php/jtim/article/view/1811