Tehran University of Medical Sciences Traditional and Integrative Medicine 2476-5104 10 3 2025 09 07 286 293 Somayeh Aghighi School of Unani Medicine, Hamdard University, New Delhi, India Maryam Moghimi Masiha Teb Shomal Knowledge-Based Cooperation, Sari, Iran Gholamreza Kordafshari School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran Hoorieh Mohammadi Kenari Institute for Studies in Medical History, Persian and Complementary Medicine, Iran University of Medical Sciences, Tehran, Iran Amir Abbas Kordafshari Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran 2024 10 16 2025 02 02 Osteomyelitis of the lower extremity is a commonly encountered problem in patients with diabetes and is an important cause of amputation and admission to the hospital. The patient presented in this article was a 52-year-old diabetic man with a diabetic foot osteomyelitis who was referred to Vali-e-Asr Persian medicine clinic. He was treated with Persian medicine methods. The treatment methods of Persian medicine were: modification of lifestyle such as sleep and nutrition, oral herbal therapy, wound washing with herbal decoctions, dry cupping, wet cupping, venesection and leech therapy. During the period of 52 days, the foot ulcer and the osteomyelitis were improved. This case report demonstrates that using the capacities of Persian medicine in addition to conventional treatments, helped to markedly improve the patient’s condition. https://jtim.tums.ac.ir/index.php/jtim/article/view/1795