Tehran University of Medical Sciences Traditional and Integrative Medicine 2476-5104 10 3 2025 09 07 294 310 Samsi Salaman Department of Pharmacy, Apollo College of Pharmacy, Kanchipuram, Tamil Nadu, India Omveer Singh Department of Pharmacy Practice, Maharishi Markandeswar University, Deemed University, Ambala, Haryana, India Smita Jain Department of Pharmacy, School of Chemical Sciences and Pharmacy, Central University of Rajasthan, Rajasthan, India R Velmurugan Department of Pharmacology, Saveetha College of Pharmacy, Saveetha Institute of Medical and Technical Sciences, Chennai, India Saraswati Patel Department of Pharmacology, Saveetha College of Pharmacy, Saveetha Institute of Medical and Technical Sciences, Chennai, India 2024 07 22 2025 02 03 The eyes, vital sensory organs, are particularly vulnerable to various ophthalmic conditions. Conjunctivitis, or “pink eye”, is one such condition characterized by inflammation and redness of the conjunctival mucosa, caused by both infectious and non-infectious agents. Affecting approximately 6 million people annually in the United States alone, its highly contagious nature presents a public health concern. Current treatments, predominantly synthetic drugs, often result in undesirable side effects. In response, there is growing interest in exploring herbal remedies as safer alternatives. Medicinal plants, rich in bioactive compounds such as alkaloids, glycosides, and terpenoids, show potential in managing conjunctivitis. Specific herbs, including Euphrasia officinalis L. (eyebright), Matricaria chamomilla L. (chamomile), and Aloe vera (L.) Burm.f., have demonstrated promising results in in vitro and animal studies by mitigating mast cell degranulation and modulating key inflammatory pathways. This review aims to delve into the efficacy, safety, and mechanisms of action of these and other herbal treatments for conjunctivitis, offering a focused evaluation of their therapeutic potential. https://jtim.tums.ac.ir/index.php/jtim/article/view/1687