Tehran University of Medical Sciences Traditional and Integrative Medicine 2476-5104 3 4 2018 12 22 196 206 EN Marjan Mahjour Department of Persian Medicine, School of Persian and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Arash Khoushabi Health Department, Mashhad University of Medical Sciences, Mashhad, Iran. Mohammad Reza Noras Department of Persian Medicine, School of Persian and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. 2018 06 16 2018 08 20 Cancer is the second cause of mortality in the world causing poor quality of life. Persian Medicine (PM) is mentioned about cancer in details. Many herbs are claimed to be useful in cancer. This paper aimed to search the most common herbal drugs affecting the cancer based on PM literature. This is a review study based on PM literatures and the electronic databases such as Pub Med and Scopus with the terms like herbal drug and cancer. The study found 15 herbs affecting the cancer. Most of these herbs were investigated in the recent studies. It is recommended further evaluation on plants mentioned in PM books, particularly those with no clinical trials or laboratory tests. https://jtim.tums.ac.ir/index.php/jtim/article/view/152