Tehran University of Medical Sciences Traditional and Integrative Medicine 2476-5104 9 3 2024 09 28 267 274 Minakshi Pandey Sharda School of Pharmacy, Sharda University, U.P., India Meenakshi Bajpai Institute of Pharmaceutical Research, GLA University, U.P., India 2023 12 26 2024 07 01 Medicinal plants consist of complex chemical compounds that have been acknowledged for their important role in treating persistent human illnesses. This research concentrates on the phyto-physicochemical evaluation of Moringa oleifera Lam. extract and its in vitro anti-arthritic properties, as determined by inhibiting protein denaturation utilizing varying concentrations of the extract and a standard drug, diclofenac sodium. The study's results revealed a significant in vitro anti-arthritic impact of the extract, with an 85.8% inhibition compared to the standard drug's 99.9% inhibition. Furthermore, this research involved creating sustained-release tablets using hydroxypropyl methylcellulose (HPMC)-based formulations and various grades of hydrophilic polymers along with a fixed quantity of a hydrophobic polymer. The manufactured tablets demonstrated favourable sustained-release traits through direct compression, with the MF2 formulation showing a 73.8% cumulative release over 10 hours. https://jtim.tums.ac.ir/index.php/jtim/article/view/1334