Tehran University of Medical Sciences Traditional and Integrative Medicine 2476-5104 9 4 2024 12 28 357 363 Mohammad Mahdi Parvizi Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran AND Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran AND Smart University of Medical Sciences, Tehran, Iran AND Persian Medicine Network (PMN), Universal Scientific Education and Research Network (USERN), Tehran, Iran Nasrin Saki Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran AND Department of Dermatology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran Ehsan Amiri-Ardekani Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran AND Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran AND Department of Phytopharmaceuticals (Traditional Pharmacy), Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran Parisa Ahmadfard Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran Mehdi Pasalar Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran 2023 12 08 2024 01 08 Epidermolysis bullosa (EB) is an inherited disease that causes widespread symptoms characterized by extreme epithelial fragility. This study examined traditional, complementary, and integrative medicine (TCIM) usage among EB patients referred to clinics at Shiraz University of Medical Sciences between 2019 and 2020. We enrolled the patients with EB whose diseases were approved by a dermatologist and registered in the dermatology department and Molecular Dermatology Research Center affiliated with Shiraz University of Medical Sciences, Shiraz, Iran.  A researcher-made data gathering form, including knowledge, beliefs, practice, and the experience of the safety of TCIM, was used to collect the data. Interviews were done by phone calls, and oral consent was obtained from patients or their parents. Overall, 68 patients were included in this study. In this regard, 79.4% of the patients used TCIM by themselves or their families to manage EB. Approximately, half of the patients were not aware of the effects of the herbal medicines they used. Among medicinal plants, chicory (20.6%), thyme (16.2%), and Persian cornflower (14.7%) had the most consumption. More than half of these patients believed that medicinal plants were a less harmful treatment, and 48.5% considered them effective. In conclusion, the study revealed high medicinal plant usage among EB patients, but limited knowledge about their effectiveness. Public awareness about the benefits and risks of these remedies needs to be increased. https://jtim.tums.ac.ir/index.php/jtim/article/view/1309