Tehran University of Medical Sciences Traditional and Integrative Medicine 2476-5104 2 3 2017 09 24 107 112 EN Mohammad Ali Sahraian Department of Neurology, Sina Multiple Sclerosis Research Center, Tehran University of Medical Science, Tehran, Iran Fatemeh Masoomi School of Traditional Medicine, Tehran University of Medical Science, Tehran, Iran Marzieh Sadat Tonkaboni School of Traditional Medicine, Tehran University of Medical Science, Tehran, Iran Reihaneh Aminoroaya School of Medicine, Tehran University of Medical Science, Tehran, Iran Sayyed Alireza Moraveji Department of Community Medicine, Kashan University of Medical Science, Kashan, Iran Fatemeh Zali School of Traditional Medicine, Tehran University of Medical Science, Tehran, Iran Marzieh Aaly School of Medicine, Tehran University of Medical Science, Tehran, Iran Sara Monfaredi School of Traditional Medicine, Tehran University of Medical Science, Tehran, Iran Hossein Rezaeizadeh School of Traditional Medicine, Tehran University of Medical Science, Tehran, Iran 2017 09 22 2017 09 22 Fatigue and constipation are among the most common factors in multiple sclerosis patients. From the perspective of Persian Medicine, constipated patients are prone to fatigue and we suspected that this problem in patients with multiple sclerosis becomes more severe. The Rome III questionnaire is a valid instrument that measures the existence and severity of constipation and FSS is a scale to assess the scale of fatigue. The objective was to assess if there is an association between constipation and fatigue symptoms in patients with multiple sclerosis. Hence, 355 patients with multiple sclerosis participated in this study. Patients were divided into a constipated or non-constipated group and compared to determine the association between constipation and fatigue scores. It was seen that the level of fatigue and depression in the constipated group was significantly higher than those without constipation (P value < 0.001). According to the observed association between constipation and fatigue, and traditional Persian Medicine theories, constipation can lead to fatigue; patients with constipation had worse scores on the FSS questionnaires and future studies should assess if the treatment of constipation with suitable laxative drugs in multiple sclerosis patients leads to a reduction of fatigue. https://jtim.tums.ac.ir/index.php/jtim/article/view/101 https://jtim.tums.ac.ir/index.php/jtim/article/download/101/99