The Effect of Methanolic and Ethanolic Extracts of Ruta graveolens L. Leaves on Formalin-Induced Inflammation in Rats

  • Sayid-Mahdi Mirghazanfari Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran AND Department of Traditional Medicine, School of Medicine, AJAUniversity of Medical Sciences; Tehran, Iran
  • Alireza Abbassian Department of Iranian Traditional Medicine, School of Traditional Medicine, Tehran University of Medical Sciences,Tehran, Iran
  • Mohammad Kamalinejad Department of Pharmacognosy, School of Pharmacy, Shahid Beheshti University, Tehran, Iran
  • Seyyed-Morteza Karimian Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  • Ahmad Massoud Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Keywords: Ruta graveolens L., Inflammation, Formalin test, Traditional Iranian Medicine, Methanolic extract, Ethanolic extract

Abstract

The phenomenon of inflammation is the base of many acute and chronic diseases. New effective antiinflammatory drugs are needed to battle side effects of acute and especially chronic inflammation and incomplete treatment of patients suffering from these side effects. For this purpose, in the present study, we evaluated Ruta graveolens L. (R. graveolens) as a folk herb for treatment of inflammation.In an experimental-interventional study, anti - inflammatory effects of R. graveolens, a Persian Medicine (PM) plant, were examined with formalin-induced hind paw edema model in rats. Sodium Salicylate (300mg/kg, ip, SS) was injected as a positive control group and compared with three doses of methanolic extract of R. graveolens (Meth) (50, 100 and 200 mg/kg; i.p.), two doses of ethanolic extract of R. graveolens (Eth) (50 and 100 mg/kg; i.p.) and a group of distilled water (6 mL/kg; i.p.).The results showed that R. graveolens has acute and chronic anti-inflammatory properties and prevents inflammation. These effects were found to be effective like SS.

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Published
2016-12-12
How to Cite
1.
Mirghazanfari S-M, Abbassian A, Kamalinejad M, Karimian S-M, Massoud A. The Effect of Methanolic and Ethanolic Extracts of Ruta graveolens L. Leaves on Formalin-Induced Inflammation in Rats. Trad Integr Med. 1(4):136-141.
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Research Article(s)